Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Eugene, Schneider"'
Autor:
Nicholas J. Viney, Shuling Guo, Li‐Jung Tai, Brenda F. Baker, Mariam Aghajan, Shiangtung W. Jung, Rosie Z. Yu, Sheri Booten, Heather Murray, Todd Machemer, Sebastien Burel, Sue Murray, Gustavo Buchele, Sotirios Tsimikas, Eugene Schneider, Richard S. Geary, Merrill D. Benson, Brett P. Monia
Publikováno v:
ESC Heart Failure, Vol 8, Iss 1, Pp 652-661 (2021)
Abstract Aims Amyloidogenic transthyretin (ATTR) amyloidosis is a fatal disease characterized by progressive cardiomyopathy and/or polyneuropathy. AKCEA‐TTR‐LRx (ION‐682884) is a ligand‐conjugated antisense drug designed for receptor‐mediat
Externí odkaz:
https://doaj.org/article/3297462a8e6e4c1081fbb6040b37c72e
Autor:
John K. Diep, Rosie Z. Yu, Nicholas J. Viney, Eugene Schneider, Shuling Guo, Scott Henry, Brett Monia, Richard Geary, Yanfeng Wang
Publikováno v:
British Journal of Clinical Pharmacology. 88:5389-5398
Transthyretin-mediated amyloidosis is a progressive and fatal disease caused by the build-up of misfolded transthyretin (TTR) protein. Eplontersen is a triantennary N-acetyl galactosamine (GalNAc3)-conjugated antisense oligonucleotide targeting TTR m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cf398f01a3cd3a211509b8e0991145
https://doi.org/10.1111/bcp.15468
https://doi.org/10.1111/bcp.15468
Autor:
Chafic Karam, Julian Gillmore, Gengshi Chen, Nia Jenkins, Mike Hale, Gemma Taylor, Jersey Chen, Nicholas Viney, Eugene Schneider
Publikováno v:
Wednesday, April 26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d20b382a933943fd70363473bef7663
https://doi.org/10.1212/wnl.0000000000202150
https://doi.org/10.1212/wnl.0000000000202150
Autor:
Teresa Coelho, Márcia Waddington Cruz, Chi-Chao Chao, Yeşim Parman, Jonas Wixner, Markus Weiler, Fabio A. Barroso, Noel R. Dasgupta, Shiangtung W. Jung, Eugene Schneider, Nicholas J. Viney, P. James B. Dyck, Yukio Ando, Julian D. Gillmore, Sami Khella, Morie A. Gertz, Laura Obici, John L. Berk
Introduction: Hereditary transthyretin (ATTRv) amyloidosis is a rare, severe, progressive, debilitating, and ultimately fatal disease caused by systemic deposition of transthyretin (TTR) amyloid fibrils. ATTRv amyloidosis occurs in both males and fem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5798a91e42710915de5d07acf1a118
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202005
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202005
Autor:
Teresa, Coelho, Márcia, Waddington Cruz, Chi-Chao, Chao, Yeşim, Parman, Jonas, Wixner, Markus, Weiler, Fabio A, Barroso, Noel R, Dasgupta, Shiangtung W, Jung, Eugene, Schneider, Nicholas J, Viney, P James B, Dyck, Yukio, Ando, Julian D, Gillmore, Sami, Khella, Morie A, Gertz, Laura, Obici, John L, Berk
Publikováno v:
Neurology and therapy.
Hereditary transthyretin (ATTRv) amyloidosis is a rare, severe, progressive, debilitating, and ultimately fatal disease caused by systemic deposition of transthyretin (TTR) amyloid fibrils. ATTRv amyloidosis occurs in both males and females. Eplonter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c0d634ce090de30cb2abfbcb2a10c86
https://pubmed.ncbi.nlm.nih.gov/36525140
https://pubmed.ncbi.nlm.nih.gov/36525140
Autor:
Shiangtung W. Jung, Li Jung Tai, Márcia Waddington-Cruz, William J. Litchy, Sotirios Tsimikas, Peter J. Dyck, Cecilia Monteiro, Gustavo Buchele, Julian D. Gillmore, Michela Brambatti, John L. Berk, Eugene Schneider, Yukio Ando, Teresa Coelho, Morie A. Gertz, Merrill D. Benson, Nicholas J. Viney, Louis O'Dea, Richard S. Geary, Brett P. Monia, Sami Khella, Laura Obici
Publikováno v:
Neurology and therapy, vol 10, iss 1
Neurology and Therapy
Neurology and Therapy
Introduction AKCEA-TTR-LRx is a ligand-conjugated antisense (LICA) drug in development for the treatment of hereditary transthyretin amyloidosis (hATTR), a fatal disease caused by mutations in the transthyretin (TTR) gene. AKCEA-TTR-LRx shares the sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae92472f0364a8018070ff0215ebd0d
https://doi.org/10.1007/s40120-021-00235-6
https://doi.org/10.1007/s40120-021-00235-6
Autor:
Yanfeng Wang, John K. Diep, Rosie Z. Yu, Eunju Hurh, Ewa Karwatowska‐Prokopczuk, Eugene Schneider, Scott Henry, Sanjay Bhanot, Richard S. Geary
Publikováno v:
Journal of clinical pharmacologyReferences.
The pharmacokinetics (PK) of 2'-O-methoxyethyl and phosphorothioate antisense oligonucleotides (ASOs), with or without N-acetyl galactosamine conjugation, have been well characterized following subcutaneous or intravenous drug administration. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60c46dc27f55a183d4b9afa6f7b0ecf
https://pubmed.ncbi.nlm.nih.gov/35801818
https://pubmed.ncbi.nlm.nih.gov/35801818
Autor:
Lauré M. Fijen, Marc A. Riedl, Laura Bordone, Jonathan A. Bernstein, Jason Raasch, Raffi Tachdjian, Timothy Craig, William R. Lumry, Michael E. Manning, Veronica J. Alexander, Kenneth B. Newman, Alexey Revenko, Brenda F. Baker, Charvi Nanavati, A. Robert MacLeod, Eugene Schneider, Danny M. Cohn
Publikováno v:
The New England journal of medicine, 386(11), 1026-1033. Massachussetts Medical Society
BACKGROUND: Hereditary angioedema is characterized by recurrent and unpredictable swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein production by antisense oligonucleotide treatment (donidalorsen) may re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a16b30232910dd9e1208365ce91cad3
https://pubmed.ncbi.nlm.nih.gov/35294818
https://pubmed.ncbi.nlm.nih.gov/35294818
Autor:
Gwendolyn E. Kaeser, Richard S Geary, Danny M. Cohn, Brenda F. Baker, Shuting Xia, Marcel Levi, Nicholas J. Viney, Lauré M. Fijen, Erik S.G. Stroes, Charvi Nanavati, Joost C. M. Meijers, Eugene Schneider, Veronica J Alexander
Publikováno v:
New England journal of medicine, 383(13), 1242-1247. Massachussetts Medical Society
Hereditary angioedema is characterized by recurrent and unpredictable episodes of subcutaneous and mucosal swelling that can be life threatening. IONIS-PKK-LRx is a ligand-conjugated antisense oligonucleotide designed for receptor-mediated delivery t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaabd31b958b313a998dbacd6b6902a
https://doi.org/10.1056/nejmoa1915035
https://doi.org/10.1056/nejmoa1915035
Autor:
Eugene Schneider, Li-Jung Tai, Sebastien A. Burel, Padmakumar Narayanan, Joseph A. Tami, Lijiang Shen, Joseph L. Witztum, T. Jesse Kwoh, Scott P. Henry, Suzanne Paz, Brett P. Monia, Steven G. Hughes, Jeffery A Engelhardt, Sanford J. Shattil, Shuting Xia, Todd Machemer, Brian R. Curtis
Publikováno v:
Nucleic Acid Therapeutics. 30:94-103
Inotersen, a 2'-O-methoxyethyl (2'-MOE) phosphorothioate antisense oligonucleotide, reduced disease progression and improved quality of life in patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) in the NEURO-TTR and NEU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3ffffb1daa283b051e7ec72a1e47a2
https://doi.org/10.1089/nat.2019.0829
https://doi.org/10.1089/nat.2019.0829