Výsledky vyhledávání - "Eugene, Bratoeff"

Síntesis, evaluación biológica y relaciones estructura-actividad de nuevos antiandrógenos esteroidales

Autor: Karen Nayelly Córdova Franco, Gladys Jaquelinne Nieves Zamudio, †Eugene Bratoeff, Marisa Cabeza Salinas, Guillermina Yazmín Arellano Salazar

Publikováno v: Latin American Journal of Development. 4:967-971

Se sintetizaron 3β-ésteres 17-metoxilados derivados de la deshidroepiandrosterona con el fin de ser utilizados como agentes terapéuticos para el tratamiento de la Hiperplasia Prostática Benigna (HPB) o el Cáncer de Próstata (CaP), ya sea median

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50d3564ebce1e7e10d74d76ce94ec6de
https://doi.org/10.46814/lajdv4n3-025

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Synthesis, in silico, and in vivo anti-inflammatory evaluation of 3β-cinnamoyloxy substituted pregna-4,16-diene-6,20-diones derivatives

Autor: Juan R. Salazar, Dulce María Meneses-Ruiz, Fernando Manuel Mancha-Meléndez, Eugene Bratoeff, Erick Francisco Puertas-Santamaría, Elkin Eduardo Sanabria-Chanaga, Marco A. Loza-Mejía

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:12184-12193

Pregnane derivatives have been studied mainly for their 5α-reductase activity. However, the anti-inflammatory activities of such compounds are still poorly explored. In the search for new anti-inflammatory agents, seven new pregnane derivatives 6a-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c4f059044cdc22a6c0f0efcc789c7ed
https://doi.org/10.1080/07391102.2021.1969279

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In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands

Autor: Juan Soriano, Marisa Cabeza, Yvonne Heuze, Eugene Bratoeff, Lucero Bautista

Publikováno v: Current Enzyme Inhibition. 17:16-25

Introduction: 5α-reductase inhibitors have been proven useful for the treatment of prostate diseases, which can be due to the unregulated activity of 5α-reductase enzyme. This study was focused on determining the activity of four different derivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::056d6628aaec27946ca8a3f56e6ed41d
https://doi.org/10.2174/1573408016999200928153524

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Effect of Pregnenolone Derivatives on the Selective Inhibition of 5α-Reductase 2 Activity

Autor: Lucero Bautista, Eugene Bratoeff, Juan Soriano, Marisa Cabeza, Yvonne Heuzr

Publikováno v: Current Enzyme Inhibition. 15:179-189

Background:Benign prostatic hyperplasia and prostate cancer are androgen-dependent diseases, and dihydrotestosterone (DHT), a 5α-reduced metabolite of testosterone (T), has been implicated as a causative factor in the progression of these diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5604fb2b26cf936fc0e5a8b4e7966d8
https://doi.org/10.2174/1573408015666191105144355

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Synthesis

Autor: Elkin, Sanabria-Chanaga, Dulce María, Meneses-Ruiz, Erick Francisco, Puertas-Santamaría, Fernando Manuel, Mancha-Meléndez, Eugene, Bratoeff, Marco A, Loza-Mejía, Juan Rodrigo, Salazar

Publikováno v: Journal of biomolecular structuredynamics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca34aa4e3edc074efc0d7794b818b122
https://pubmed.ncbi.nlm.nih.gov/34468278

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Synthesis and cytotoxic effect of pregnenolone derivatives with one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3

Autor: Alejandra Chávez-Riveros, Luis D. Miranda, Abigail Cruz Noriega, María Teresa Ramírez Apan, Eugene Bratoeff

Publikováno v: Steroids. 131:37-45

Four series of pregnenolone derivatives having one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3 were synthetized to compare their cytotoxicity effect. The final compounds were evaluated on three human cancer cell lines: PC-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8615ee3b911987f2b5b693910dce243
https://doi.org/10.1016/j.steroids.2018.01.004

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Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5α-reductase 2 and with cytotoxic activity in cancer cells

Autor: Marisol Bravo, Eugene Bratoeff, Isabel Moreno, Teresa Ramírez-Apan, Yvonne Heuze, Lucero Bautista, Aylin Viviana Silva-Ortiz, Juan Soriano, Marisa Cabeza

Publikováno v: Bioorganic & Medicinal Chemistry. 25:1600-1607

The aim of this study was to synthesize several 16-dehydropregnenolone derivatives containing an imidazole ring at C-21 and a different ester moiety at C-3 as inhibitors of 5α-reductase 1 and 2 isoenzymes. Their binding capacity to the androgen rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eadfe43807b2d062c460d5fa4d36e9
https://doi.org/10.1016/j.bmc.2017.01.018

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Synthesis of 17β-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line

Autor: Berenice Alvarez-Manrique, Marisa Cabeza, María Teresa Ramírez-Apan, Francisco Cortés-Benítez, Eugene Bratoeff

Publikováno v: European Journal of Medicinal Chemistry. 121:737-746

In this study, we report the synthesis and anti-proliferative effect of a set of eight androst-4-ene-3-one derivatives with different arylcarbamoyl groups at C-17. The novel compounds were prepared from commercially available 3β-hydroxy-5-pregnen-20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844d76f09ae910370a12df4eceb0ef13
https://doi.org/10.1016/j.ejmech.2016.05.059

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