Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Eugen Kolossov"'
Autor:
Elke Gabriel, Stephanie Schievenbusch, Eugen Kolossov, Jan G Hengstler, Tamara Rotshteyn, Heribert Bohlen, Dirk Nierhoff, Jürgen Hescheler, Irina Drobinskaya
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44912 (2012)
Embryonic stem cell-derived hepatocyte precursor cells represent a promising model for clinical transplantations to diseased livers, as well as for establishment of in vitro systems for drug metabolism and toxicology investigations. This study aimed
Externí odkaz:
https://doaj.org/article/955c0b2c2cd349a79bc40d242d6cdad9
Autor:
Niels Fertig, Eugen Kolossov, Sonja Stoelzle, Alison Haythornthwaite, Heribert Bohlen, Andrea Brüggemann, Michael George, Ralf Kettenhofen
Publikováno v:
SLAS Discovery. 16:910-916
Cardiovascular side effects are critical in drug development and have frequently led to late-stage project terminations or even drug withdrawal from the market. Physiologically relevant and predictive assays for cardiotoxicity are hence strongly dema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4942aed9de4d75b5b0ed3e2b0680943a
https://doi.org/10.1177/1087057111413924
https://doi.org/10.1177/1087057111413924
Autor:
Irina Drobinskaya, Tomo Saric, Eugen Kolossov, Heribert Bohlen, Jürgen Hescheler, Reinhard G. Bretzel, Thomas Linn
Publikováno v:
Stem Cells. 26:2245-2256
Potential therapeutic applications of embryonic stem cell (ESC)-derived hepatocytes are limited by their relatively low output in differentiating ESC cultures, as well as by the danger of contamination with tumorigenic undifferentiated ESCs. To addre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da639a676d4106e4312e53aa1f7c2666
https://doi.org/10.1634/stemcells.2008-0387
https://doi.org/10.1634/stemcells.2008-0387
Publikováno v:
Advanced Drug Delivery Reviews. 60:146-159
Progress in gene therapy has produced promising results that translate experimental research into clinical treatment. Gene modification has been extensively employed in cell transplantation. The main barrier is an effective gene delivery system. Seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae5c44b579ad0195bbf4aa4b097357f
https://doi.org/10.1016/j.addr.2007.08.039
https://doi.org/10.1016/j.addr.2007.08.039
Publikováno v:
Herz. 27:589-597
Cardiomyopathy is characterized by the loss of functional cardiomyocytes resulting in heart failure. More recently, there is increasing evidence from animal studies that transplantation of cardiomyocytes may represent a valuable approach for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744e312b9c3ceea60b176cc8b8b096ea
https://doi.org/10.1007/s00059-002-2423-2
https://doi.org/10.1007/s00059-002-2423-2
Publikováno v:
Toxicology in Vitro. 16:589-597
The capacity of pluripotent embryonic stem cells (ESC) to differentiate in vitro into various tissues provides the opportunity to develop an in vitro assay for investigating mechanisms of developmental toxicity. ESC clones carrying tissue specific re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6f633c73a16462176877ef07324caa
https://doi.org/10.1016/s0887-2333(02)00052-8
https://doi.org/10.1016/s0887-2333(02)00052-8
Autor:
Gottfried Brem, Klaus Tiemann, Klaus Addicks, Ying Xia, Michaela Fleischmann, Wilhelm Bloch, Eva Stoecker, Robert Stehle, Bernd K. Fleischmann, Gabriele Pfitzer, Heribert Bohlen, Eugen Kolossov, Sharon Siedner, Zhong J. Lu, Armin Welz, Wilhelm Roell, Juergen Hescheler
Publikováno v:
Circulation. 105:2435-2441
Background — Cellular cardiomyoplasty is discussed as an alternative therapeutic approach to heart failure. To date, however, the functional characteristics of the transplanted cells, their contribution to heart function, and most importantly, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40400247c5082acc039f1921b878bc87
https://doi.org/10.1161/01.cir.0000016063.66513.bb
https://doi.org/10.1161/01.cir.0000016063.66513.bb
Autor:
Axel Raible, Bernd K. Fleischmann, Shohreh Kazemi, Klaus Addicks, Wilhelm Bloch, Daniela Wenzel, Nibedita Lenka, Eugen Kolossov, Philipp Sasse, Juergen Hescheler
Publikováno v:
Cellular Physiology and Biochemistry. 12:55-62
Primary vascular plexus originate from angioblasts through a process called vasculogenesis. The precise role of basic fibroblast growth factor (bFGF) and the vascular endothelial growth factor (VEGF) are both suggested as key regulators in vasculogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2172c09f79c30beefb1287d878db40
https://doi.org/10.1159/000063781
https://doi.org/10.1159/000063781
Autor:
Stefan Arnhold, Eugen Kolossov, Franz-Josef Klinz, Christian Andressen, Klaus Addicks, Jürgen Hescheler, Doris Lenartz, Klaus Kruttwig, Volker Sturm
Publikováno v:
Journal of Neurosurgery. 93:1026-1032
Object. The aim of this investigation was to assess new information concerning the capacity of transplanted embryonic stem cell (ESC)-derived neuronal cells to migrate into host brain and to evaluate these cells as a possible source for cell replacem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbf47a523a1b7ebd6163f64e125e248f
https://doi.org/10.3171/jns.2000.93.6.1026
https://doi.org/10.3171/jns.2000.93.6.1026
Autor:
Gottfried Brem, Christian Andressen, Juergen Hescheler, Wilhelm Bloch, Klaus Addicks, Mathias Müller, Eugen Kolossov, Bernd K. Fleischmann, Michaela Fleischmann
Publikováno v:
FEBS Letters. 440:370-376
We demonstrate the establishment of transgenic mice, where the expression of the green fluorescent protein (GFP) is under control of the human cardiac alpha-actin promoter. These mice display cardiac specific GFP expression already during early embry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3110a02ed66f926c0c8d754db5d19a
https://doi.org/10.1016/s0014-5793(98)01476-8
https://doi.org/10.1016/s0014-5793(98)01476-8