Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Eugen Kerkhoff"'
Autor:
Martin Kollmar, Tobias Welz, Aishwarya Ravi, Thomas Kaufmann, Noura Alzahofi, Klas Hatje, Asmahan Alghamdi, Jiyu Kim, Deborah A. Briggs, Annette Samol-Wolf, Olena Pylypenko, Alistair N. Hume, Pawel Burkhardt, Jan Faix, Eugen Kerkhoff
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-21 (2024)
Abstract An important question in cell biology is how cytoskeletal proteins evolved and drove the development of novel structures and functions. Here we address the origin of SPIRE actin nucleators. Mammalian SPIREs work with RAB GTPases, formin (FMN
Externí odkaz:
https://doaj.org/article/0ef371bb0f37464e940f4e2fa0201a73
Autor:
Noura Alzahofi, Tobias Welz, Christopher L. Robinson, Emma L. Page, Deborah A. Briggs, Amy K. Stainthorp, James Reekes, David A. Elbe, Felix Straub, Wouter W. Kallemeijn, Edward W. Tate, Philip S. Goff, Elena V. Sviderskaya, Marta Cantero, Lluis Montoliu, Francois Nedelec, Amanda K. Miles, Maryse Bailly, Eugen Kerkhoff, Alistair N. Hume
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity
Externí odkaz:
https://doaj.org/article/4f3d5075c67d4d559d886e183af1f636
Autor:
Olena Pylypenko, Tobias Welz, Janine Tittel, Martin Kollmar, Florian Chardon, Gilles Malherbe, Sabine Weiss, Carina Ida Luise Michel, Annette Samol-Wolf, Andreas Till Grasskamp, Alistair Hume, Bruno Goud, Bruno Baron, Patrick England, Margaret A Titus, Petra Schwille, Thomas Weidemann, Anne Houdusse, Eugen Kerkhoff
Publikováno v:
eLife, Vol 5 (2016)
There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleato
Externí odkaz:
https://doaj.org/article/c2c1af684db44be18ca98b689ff18474
Autor:
Daniel Andritschke, Sabrina Dilling, Mario Emmenlauer, Tobias Welz, Fabian Schmich, Benjamin Misselwitz, Pauli Rämö, Klemens Rottner, Eugen Kerkhoff, Teiji Wada, Josef M Penninger, Niko Beerenwinkel, Peter Horvath, Christoph Dehio, Wolf-Dietrich Hardt
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161965 (2016)
Salmonella Typhimurium (S. Tm) is a leading cause of diarrhea. The disease is triggered by pathogen invasion into the gut epithelium. Invasion is attributed to the SPI-1 type 3 secretion system (T1). T1 injects effector proteins into epithelial cells
Externí odkaz:
https://doaj.org/article/5babca2e466f425b919d9eb22da76f5c
Autor:
J Margit Oelkers, Marlene Vinzenz, Maria Nemethova, Sonja Jacob, Frank P L Lai, Jennifer Block, Malgorzata Szczodrak, Eugen Kerkhoff, Steffen Backert, Kai Schlüter, Theresia E B Stradal, J Victor Small, Stefan A Koestler, Klemens Rottner
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19931 (2011)
The actin cytoskeleton is continuously remodeled through cycles of actin filament assembly and disassembly. Filaments are born through nucleation and shaped into supramolecular structures with various essential functions. These range from contractile
Externí odkaz:
https://doaj.org/article/d34b14bc521442dea6a348502f3dc543
Autor:
Tobias Welz, Eugen Kerkhoff
Publikováno v:
Journal of Cell Science. 136
Looking back at two decades of research on SPIRE actin nucleator proteins, the first decade was clearly dominated by the discovery of SPIRE proteins as founding members of the novel WH2-domain-based actin nucleators, which initiate actin filament ass
Autor:
Anna Holthenrich, Julian Terglane, Johannes Naß, Magdalena Mietkowska, Eugen Kerkhoff, Volker Gerke
Publikováno v:
Cellular and Molecular Life Sciences
Weibel–Palade bodies (WPB) are endothelial cell-specific storage granules that regulate vascular hemostasis by releasing the platelet adhesion receptor von Willebrand factor (VWF) following stimulation. Fusion of WPB with the plasma membrane is acc
Autor:
Martin Kollmar, Rafael Brandao, Eugen Kerkhoff, Anna Huber, Hannah Alberico, Annette Samol-Wolf, Tobias Welz, Felix Straub, Javier Martin-Gonzalez, Cord Brakebusch, Dori C. Woods
Subcellular localisation of mitochondria provides a spatial and temporal organisation for cellular energy demands. Long-range mitochondrial transport is mediated by microtubule tracks and associated dynein and kinesin motor proteins. The actin cytosk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::074ed78e348225aa5d8ff1ceb5bf7740
https://doi.org/10.1101/2020.06.19.161109
https://doi.org/10.1101/2020.06.19.161109
Autor:
Elena V. Sviderskaya, Maryse Bailly, Lluis Montoliu, François Nédélec, Philip S. Goff, Amanda K. Miles, Noura Alzahofi, Edward W. Tate, Alistair N. Hume, Amy K. Stainthorp, Emma L. Page, David A. Elbe, James Reekes, Eugen Kerkhoff, Felix Straub, Wouter W. Kallemeijn, Deborah A. Briggs, Tobias Welz, Marta Cantero, Christopher L. Robinson
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
instname
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
© The Author(s) 2020.
Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently disco
Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5799252f02fde07113db1543c40dc3
http://hdl.handle.net/10261/229694
http://hdl.handle.net/10261/229694
Autor:
Markus Schulze, Jörg Reinders, Sabine Hoja, Markus J. Riemenschneider, Stefan Swoboda, Johann M. B. Simbürger, Susanne Brüggemann, Eugen Kerkhoff, Christ Violonchi, Tobias Welz
Publikováno v:
Brain Pathol
Glioblastoma (GBM) represents the most common and most malignant type of primary brain tumor and significantly contributes to cancer morbidity and mortality. Invasion into the healthy brain parenchyma is a major feature of glioblastoma aggressiveness