Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eugen Falk"'
Autor:
Gerrit Schubert, Georg Neckermann, Günther Wess, Hoffmann Axel, Matthias Urmann, Alfons Enhsen, Werner Kramer, Eugen Falk
Publikováno v:
Journal of Controlled Release. 46:17-30
For the development of future drugs two aspects are of major importance, a site-specific drug action without adverse side-effects and a preferably oral applicability. The liver has a central role in drug action and many disorders are unique to the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfa22c03af2b0762f08605858c33ff89
https://doi.org/10.1016/s0168-3659(96)01599-4
https://doi.org/10.1016/s0168-3659(96)01599-4
Autor:
Karl-Heinz Baringhaus, Jurgen A. Horz, Lutz Nickau, Siegfried Schulz, Alfons Enhsen, Ernst Petzinger, Eugen Falk, Hoffmann Axel, Georg Neckermann, Günther Wess, Werner Kramer, Stefan Müllner, Heiner Glombik
Publikováno v:
Hepatology. 22:1801-1811
To obtain prodrugs with affinity to liver parenchymal cells, the hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors HR 780 and lovastatin (syn. mevinolin) were conjugated with the bile acids cholic acid, taurocholic acid, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a59ef706b5da691d21a73f5f09d58f4
https://doi.org/10.1002/hep.1840220629
https://doi.org/10.1002/hep.1840220629
Autor:
Maike Glien, Marcus Korn, Wolfgang Linz, Hartmut Rütten, Andreas W. Herling, Heiner Glombik, Hans Ludwig Schäfer, Eugen Falk, Wolfgang Wendler
Aim: AVE8134 is a structurally novel potent PPARα agonist. The aim of this study is to investigate the efficacy of AVE8134 on lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats. Methods: A cell based PPAR Gal4 transac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445fa6449a2df9a2dc8fa03c9b595fb7
https://europepmc.org/articles/PMC4010268/
https://europepmc.org/articles/PMC4010268/
Autor:
Paulus Wohlfart, Wolfgang Linz, Kristin Breitschopf, Hans-Ludwig Schäfer, Werner Kramer, Manuel Baader, Eugen Falk, Martin Gerl, Hartmut Rütten
Publikováno v:
Linz, W, Wohlfart, P, Baader, M, Breitschopf, K, Falk, E, Schäfer, H-L, Gerl, M, Kramer, W & Rütten, H 2009, ' The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats ', Acta Pharmacologica Sinica, vol. 30, no. 7, pp. 935-46 . https://doi.org/10.1038/aps.2009.58
Udgivelsesdato: 2009-Jul AIM:To investigate the efficacy of the peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, AVE8134, in cellular and experimental models of cardiac dysfunction and heart failure. METHODS:In Sprague Dawley rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aeb343749c63a787691e0e7caaed257
https://europepmc.org/articles/PMC4006644/
https://europepmc.org/articles/PMC4006644/
Autor:
Ernst Petzinger, Klaus Bock, Axel Hoffman, Günther Wess, Dietrich Gantz, Georg Neckermann, Stephen D. Turley, Werner Kramer, Siefried Schulz, Lutz Nickau, Eugen Falk, Alfons Enhsen, John M. Dietschy
Publikováno v:
Biochimica et biophysica acta. 1227(3)
The target organ for HMG-CoA reductase inhibitors to decrease cholesterol biosynthesis in hypercholesterolemic patients is the liver. Since bile acids undergo an enterohepatic circulation showing a strict organotropism for the liver and the small int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3d727fb622870b111bf70fb91e2fcc
https://pubmed.ncbi.nlm.nih.gov/7986821
https://pubmed.ncbi.nlm.nih.gov/7986821
Publikováno v:
European journal of biochemistry. 186(3)
Due to their conjugated double bonds the leukotrienes themselves are photolabile compounds and may therefore be used directly for photoaffinity labeling of leukotriene binding sites. Cryofixation eliminates unspecific labeiing taking place in solutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddf966483984ed01601845528d1f2ff
https://pubmed.ncbi.nlm.nih.gov/2558017
https://pubmed.ncbi.nlm.nih.gov/2558017
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