Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Eugen Dhimolea"'
Autor:
Eugen Dhimolea
Publikováno v:
The Application of Clinical Genetics, Vol 2011, Iss default, Pp 21-27 (2011)
Eugen DhimoleaTufts University School of Medicine, Boston, MA, USAAbstract: Cryopyrin-associated periodic syndrome (CAPS) comprises a group of rare, but severe, inherited autoinflammatory disorders associated with aberrant secretion of interleukin (I
Externí odkaz:
https://doaj.org/article/0d8b2080fed34764bdf50f3f150c6a69
Autor:
Eugen Dhimolea, Perinaaz R Wadia, Tessa J Murray, Matthew L Settles, Jo D Treitman, Carlos Sonnenschein, Toshi Shioda, Ana M Soto
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e99800 (2014)
Exposure to environmental estrogens (xenoestrogens) may play a causal role in the increased breast cancer incidence which has been observed in Europe and the US over the last 50 years. The xenoestrogen bisphenol A (BPA) leaches from plastic food/beve
Externí odkaz:
https://doaj.org/article/230442f2a5604ccd9b4feb913d75a799
Autor:
Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades
Publikováno v:
de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research
Nature Cancer, 4(5), 754-773. Nature Research
Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe
Autor:
Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy
Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f5cfbb31b0403c58a8d2a79717db84
https://doi.org/10.1158/2159-8290.22540768.v1
https://doi.org/10.1158/2159-8290.22540768.v1
Autor:
Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy
Network analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbac20e3461c41b2232a959a17a0481
https://doi.org/10.1158/2159-8290.22540750
https://doi.org/10.1158/2159-8290.22540750
Autor:
Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy
Patients with acute myeloid leukemia (AML) frequently relapse after chemotherapy, yet the mechanism by which AML reemerges is not fully understood. Herein, we show that primary AML cells enter a senescence-like phenotype following chemotherapy in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665ad1a576a4b28fc5a709bc2cc4de1
https://doi.org/10.1158/2159-8290.c.6549469.v1
https://doi.org/10.1158/2159-8290.c.6549469.v1
Autor:
Mark Rolfe, Daniel J. Anderson, Constantine S. Mitsiades, Jeffrey L. Wolf, Thomas G. Martin, Han-Jie Zhou, Laura Shawver, David Wustrow, F. Michael Yakes, Szerenke Kiss Von Soly, Christoph Driessen, Marianne Kraus, P. Leif Bergsagel, Marta Chesi, Jinhai Wang, Julie Rice, Christine Lam, Arun P. Wiita, Bing Yao, Grace J. Lee, Stephen T. Wong, Zhi Yong Wu, Mary-Kamala Menon, Ferdie Soriano, Emily M. King, Megan Murnane, Eduardo Valle, Eugen Dhimolea, Stevan Djakovic, Blake T. Aftab, Ronan Le Moigne
Supplementary Figure S1:Effect of CB-5083 on cell growth and survival in multiple myeloma and solid tumor cell lines; Supplementary Figure S2:CB-5083 activates UPR;Supplementary Figure S3:CB-5083 transcriptional response is unique in comparison to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569299e78d46c92329042958fa03bafc
https://doi.org/10.1158/1535-7163.22509273
https://doi.org/10.1158/1535-7163.22509273
Autor:
Mark Rolfe, Daniel J. Anderson, Constantine S. Mitsiades, Jeffrey L. Wolf, Thomas G. Martin, Han-Jie Zhou, Laura Shawver, David Wustrow, F. Michael Yakes, Szerenke Kiss Von Soly, Christoph Driessen, Marianne Kraus, P. Leif Bergsagel, Marta Chesi, Jinhai Wang, Julie Rice, Christine Lam, Arun P. Wiita, Bing Yao, Grace J. Lee, Stephen T. Wong, Zhi Yong Wu, Mary-Kamala Menon, Ferdie Soriano, Emily M. King, Megan Murnane, Eduardo Valle, Eugen Dhimolea, Stevan Djakovic, Blake T. Aftab, Ronan Le Moigne
Inhibition of the AAA ATPase, p97, was recently shown to be a novel method for targeting the ubiquitin proteasome system, and CB-5083, a first-in-class inhibitor of p97, has demonstrated broad antitumor activity in a range of both hematologic and sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9c3a3608da1883962d4e516df699248
https://doi.org/10.1158/1535-7163.c.6539250.v1
https://doi.org/10.1158/1535-7163.c.6539250.v1
Autor:
Constantine S. Mitsiades, Irene Georgakoudi, Myles Brown, Aedín C. Culhane, Rinath Jeselsohn, Yu Chen, Joseph H. Schwab, Nicholas Mitsiades, Dong Gao, Zhiyi Liu, Pallavi Awate, Shruti Sharma, Xiang Weng, Dhvanir Kansara, Ricardo de Matos Simoes, Eugen Dhimolea
Supplemental Materials & Methods and Figures 1-6. Sup. Figure 1. The effect of antiestrogens against ER+ BrCa spheroid cultures is attenuated by BMSCs. Sup. Figure 2. BMSCs attenuate the antiestrogen response of BrCa xenografts in vivo. Sup. Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2592e0493168e412c12d5dcb71bf783d
https://doi.org/10.1158/0008-5472.22427449
https://doi.org/10.1158/0008-5472.22427449
Autor:
Constantine S. Mitsiades, Irene Georgakoudi, Myles Brown, Aedín C. Culhane, Rinath Jeselsohn, Yu Chen, Joseph H. Schwab, Nicholas Mitsiades, Dong Gao, Zhiyi Liu, Pallavi Awate, Shruti Sharma, Xiang Weng, Dhvanir Kansara, Ricardo de Matos Simoes, Eugen Dhimolea
Although hormonal therapy (HT) inhibits the growth of hormone receptor–positive (HR+) breast and prostate cancers, HT resistance frequently develops within the complex metastatic microenvironment of the host organ (often the bone), a setting poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb0100e3894c340d1a10b497f582e965
https://doi.org/10.1158/0008-5472.c.6512674.v1
https://doi.org/10.1158/0008-5472.c.6512674.v1