Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Eugen Brailoiu"'
Autor:
Eugen Brailoiu, Jeffrey L. Barr, Hailey N. Wittorf, Saadet Inan, Ellen M. Unterwald, Gabriela Cristina Brailoiu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5147 (2024)
Sigma non-opioid intracellular receptor 1 (Sigma-1R) is an intracellular chaperone protein residing on the endoplasmic reticulum at the mitochondrial-associated membrane (MAM) region. Sigma-1R is abundant in the brain and is involved in several physi
Externí odkaz:
https://doaj.org/article/6e67c20fcdc94615a26abde6b8ee839b
Autor:
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113628- (2024)
Summary: Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to
Externí odkaz:
https://doaj.org/article/0c93f40a9db1428081d0c197d6e1ae0a
Autor:
Kristen L. Lindenau, Jeffrey L. Barr, Christopher R. Higgins, Kevin T. Sporici, Eugen Brailoiu, Gabriela C. Brailoiu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2258 (2022)
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), obtained from diet and dietary supplements, have been tested in clinical trials for the prevention or treatment of several diseases. n-3 PUFAs exert their effects by activation of free fatty acid (FFA)
Externí odkaz:
https://doaj.org/article/77971cc265084696b47e69a14a33675b
Autor:
Franklin L. Thelmo DO, Harvey Guttmann MD, Waqas Ullah MD, Ahmad Arslan MD, Eugen Brailoiu MD
Publikováno v:
Journal of Investigative Medicine High Impact Case Reports, Vol 8 (2020)
Epiphrenic esophageal diverticula (EED) is a rare condition that usually presents with dysphagia in patients with a known motility disorder. In this article, we present a unique case of EED presenting with hemoptysis with clinical workup negative for
Externí odkaz:
https://doaj.org/article/a8961e1b141446358762b79e1ada7227
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5160 (2021)
Orexin A, an endogenous peptide involved in several functions including reward, acts via activation of orexin receptors OX1 and OX2, Gq-coupled GPCRs. We examined the effect of a selective OX1 agonist, OXA (17-33) on cytosolic calcium concentration,
Externí odkaz:
https://doaj.org/article/25e34eda250646b18f9dec117b4f75c0
Autor:
Eugen Brailoiu, Sumita Chakraborty, G. Cristina Brailoiu, Pingwei Zhao, Jeffrey L. Barr, Marc A. Ilies, Ellen M. Unterwald, Mary E. Abood, Colin W. Taylor
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 330-337.e4 (2019)
Summary: Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from
Externí odkaz:
https://doaj.org/article/bba4f71ea52a4806843616fb0bce4be7
Publikováno v:
Cannabis and Cannabinoid Research.
Autor:
V. Craig Jordan, Nae J. Dun, Eric R. Prossnitz, Tudor I. Oprea, Jeffrey B. Arterburn, Anne L. Donato, Michael A. Black, Heather E. Cunliffe, Michael J. Slifker, Heather A. Shupp, Smitha Yerrum, Eugen Brailoiu, Eric A. Ariazi
Supplementary Figure 1 from The G Protein–Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor–Positive Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ffbce276b8352f022b19cd9b0322dd
https://doi.org/10.1158/0008-5472.22387254.v1
https://doi.org/10.1158/0008-5472.22387254.v1
Autor:
V. Craig Jordan, Nae J. Dun, Eric R. Prossnitz, Tudor I. Oprea, Jeffrey B. Arterburn, Anne L. Donato, Michael A. Black, Heather E. Cunliffe, Michael J. Slifker, Heather A. Shupp, Smitha Yerrum, Eugen Brailoiu, Eric A. Ariazi
Supplementary Methods from The G Protein–Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor–Positive Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a8f40cf723971791e40813a381ee4f
https://doi.org/10.1158/0008-5472.22387251
https://doi.org/10.1158/0008-5472.22387251
Autor:
Dow P. Hurst, Noori Sotudeh, Paula Morales, Eugen Brailoiu, Nadine Jagerovic, Mary E. Abood, Ana Lago-Fernandez, Patricia H. Reggio
Publikováno v:
Journal of Medicinal Chemistry. 63:14216-14227
GPR18 is a G protein-coupled receptor that belongs to the orphan class A family. Even though it shares low sequence homology with the cannabinoid receptors, CB1R and CB2R, a growing body of research suggests its relationship with the endocannabinoid