Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eugène, Cox"'
Publikováno v:
Pain and Therapy, Vol 13, Iss 1, Pp 145-159 (2024)
Abstract Introduction Acetaminophen and topical diclofenac (AtopD) have complementary mechanisms of action and are therefore candidates for combination use in osteoarthritis (OA) pain. However, an evidence gap exists on their combination use in OA pa
Externí odkaz:
https://doaj.org/article/a5b1eecb883b4f5bacc8fa8db235113e
Publikováno v:
Pain and Therapy, Vol 13, Iss 1, Pp 127-143 (2024)
Abstract Introduction The use of combination therapy of oral acetaminophen and topical diclofenac, having complementary mechanisms of action, is an attractive strategy to enhance the analgesic response in osteoarthritis (OA) pain. While topical diclo
Externí odkaz:
https://doaj.org/article/0ed00b164eb4444f82633e8861520068
Autor:
Junichi Ishigami, Andrew E. Moran, Edgar R. Miller, Nancy Zhang, Eugène Cox, Li Qin, Marc Pfister
Publikováno v:
Journal of Human Hypertension. 36:989-995
A model-based meta-analysis quantified comparative dyskalemia risk (hyper- or hypo-kalemia) in hypertensive patients treated with angiotensin receptor blockers (ARBs), a calcium channel blocker (CCB) and/or a thiazide diuretic (hydrochlorothiazide; H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64b3720f3fb0cba878c682d8587ceff2
https://doi.org/10.1038/s41371-021-00600-w
https://doi.org/10.1038/s41371-021-00600-w
Autor:
Carl M. J. Kirkpatrick, Kashyap Patel, Eileen Doyle, Samer Mouksassi, Katrina Hui, Fran Brown, Michael G. Dodds, Eugène Cox, Yuan Xiong, David Wesche, Craig R. Rayner
Publikováno v:
British Journal of Clinical Pharmacology
During a pandemic caused by a novel pathogen (NP), drug repurposing offers the potential of a rapid treatment response via a repurposed drug (RD) while more targeted treatments are developed. Five steps of model-informed drug repurposing (MIDR) are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f053bf1fc580c6eff617e7e1520239a8
Autor:
Li, Qin, Nancy, Zhang, Junichi, Ishigami, Edgar R, Miller, Marc, Pfister, Andrew E, Moran, Eugène, Cox
Publikováno v:
Journal of human hypertension. 36(11)
A model-based meta-analysis quantified comparative dyskalemia risk (hyper- or hypo-kalemia) in hypertensive patients treated with angiotensin receptor blockers (ARBs), a calcium channel blocker (CCB) and/or a thiazide diuretic (hydrochlorothiazide; H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8a742fc087b61c0d675aff56dc8bfe9
https://pubmed.ncbi.nlm.nih.gov/34556798
https://pubmed.ncbi.nlm.nih.gov/34556798
Autor:
Rik de Greef, Eugène Cox, Kathryn H. Brown, Mireille Cantarini, Craig Comisar, John Maringwa, Han Witjes, Karthick Vishwanathan
Publikováno v:
British Journal of Clinical Pharmacology. 83:1216-1226
Aims To develop a population (pop) pharmacokinetic (PK) model for osimertinib (AZD9291) and its metabolite (AZ5104) and investigate the exposure–response relationships for selected efficacy and safety parameters. Methods PK, safety and efficacy dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17b2458b8ea0886c7f3e4b0b890c347
https://doi.org/10.1111/bcp.13223
https://doi.org/10.1111/bcp.13223
Publikováno v:
British Journal of Clinical Pharmacology. 76:752-762
Aim To assess the cardiovascular effects of a new inhaled long-acting β-adrenoceptor agonist PF-00610355 in COPD patients. Methods Thirteen thousand and sixty-two heart rate measurements collected in 10 clinical studies from 579 healthy volunteers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9afba8d6dc2e7aac1b4d5439388155
https://doi.org/10.1111/bcp.12080
https://doi.org/10.1111/bcp.12080
Publikováno v:
Clinical pharmacokinetics. 52(6)
PF-00610355 is an orally inhaled long-acting β2-adrenoreceptor agonist that is being developed for the once-daily treatment of chronic obstructive pulmonary disease (COPD). The pharmacological effect is exerted in the lungs. However, systemic exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fd12c1f5a634d2e88f691b9a243ccb
https://pubmed.ncbi.nlm.nih.gov/23494982
https://pubmed.ncbi.nlm.nih.gov/23494982
Publikováno v:
British journal of clinical pharmacology. 76(5)
To assess the cardiovascular effects of a new inhaled long-acting β-adrenoceptor agonist PF-00610355 in COPD patients.Thirteen thousand and sixty-two heart rate measurements collected in 10 clinical studies from 579 healthy volunteers, asthma and CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7fe52ddba38c6ea10c37935653f0d89
https://pubmed.ncbi.nlm.nih.gov/23323609
https://pubmed.ncbi.nlm.nih.gov/23323609
Autor:
Ihab G, Girgis, Partha, Nandy, Jeffrey S, Nye, Lisa, Ford, Surya, Mohanty, Steven, Wang, Stefan, Ochalski, Marielle, Eerdekens, Eugène, Cox
Publikováno v:
Epilepsia. 51(10)
To identify and validate the efficacious monotherapy dosing regimen for topiramate in children aged 2 to10 years with newly diagnosed epilepsy using pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation bridging.Several models were develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0815cc992953d567886d8af233d9bf89
https://pubmed.ncbi.nlm.nih.gov/20880232
https://pubmed.ncbi.nlm.nih.gov/20880232