Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Euan S. Polson"'
Autor:
Jayant K. Rane, Alastair P. Droop, Davide Pellacani, Euan S. Polson, Matthew S. Simms, Anne T. Collins, Leo S.D. Caves, Norman J. Maitland
Publikováno v:
Stem Cell Reports, Vol 2, Iss 2, Pp 180-188 (2014)
Human epithelia are organized in a hierarchical structure, where stem cells generate terminally differentiated cells via intermediate progenitors. This two-step differentiation process is conserved in all tissues, but it is not known whether a common
Externí odkaz:
https://doaj.org/article/224cf99a347c42e9aa68aa3823822cce
Autor:
Henry King, Alastair Droop, Ewan E. Morrison, Ruth Morton, Susan C Short, Julie Higgins, Gary Shaw, Peter Laslo, B. da Silva, Euan S. Polson, Lynette Steele, Daniel Tams, Heather L. Martin, Matthew Adams, Heiko Wurdak, Darren C. Tomlinson, Sean E. Lawler, Marjorie Boissinot, Josie Hayes, Jacquelyn Bond, Thomas Ward
Publikováno v:
Oncogene
MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (GBM), we performed
Autor:
Ryan K. Mathew, Holly Briggs, Euan S. Polson, Alexandre Zougman, Deena M.A. Gendoo, Heiko Wurdak, Bronwyn K. Irving
Overexpression and mitosis-promoting roles of Transforming acidic coiled-coil containing protein 3 (TACC3) are well-established in many cancers, including glioblastoma (GBM). However, the effector gene networks downstream of TACC3 remain poorly defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a88f967e7d80e71d0473c39b991a22
https://doi.org/10.1101/2020.10.20.346643
https://doi.org/10.1101/2020.10.20.346643
Publikováno v:
SLAS Discovery. 23:862-868
Organoid methodology provides a platform for the ex vivo investigation of the cellular and molecular mechanisms underlying brain development and disease. The high-grade brain tumor glioblastoma multiforme (GBM) is considered a cancer of unmet clinica
Autor:
Thomas Ward, Heiko Wurdak, Barbara da Silva, Daniel Tams, Euan S. Polson, Sean E. Lawler, Jacquelyn Bond, Ewan E. Morrison, Ruth Morton, Julie Higgins, Darren C. Tomlinson, Josie Hayes, Susan C Short, Henry King, Peter Laslo, Heather L. Martin, Lynette Steele, Matthew Adams, Marjorie Boissinot, Alastair Droop
BackgroundMicroRNAs play an important role in the regulation of mRNA translation, and have therapeutic potential in cancer and other diseases.MethodsTo profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da0487a4579d34f8508c5faccc92ed2
Autor:
Courtney Williams, Hollie B. S. Griffiths, Heiko Wurdak, Joanne Marrison, Georgia Mavria, Simon J. Allison, Margherita Scarcia, Alastair Droop, Barbara da Silva, Ryan K. Mathew, Euan S. Polson, Jennifer Williams, Peter O'Toole, Lucy F. Stead, Bronwyn K. Irving, Susan C Short
Publikováno v:
Journal of Cell Science.
Tumor stem cells and malignant multicellular networks have been separately implicated in the therapeutic resistance of Glioblastoma Multiforme (GBM), the most aggressive type of brain cancer in adults. We show that small molecule inhibition of RHO-as
Autor:
Margherita Scarcia, Susan C Short, Jennifer Williams, Georgia Mavria, Alastair Droop, Euan S. Polson, Barbara da Silva, Heiko Wurdak, Lucy F. Stead, Ryan K. Mathew
SummaryTumor stem cells and malignant multicellular networks have been separately implicated in the therapeutic resistance of Glioblastoma Multiforme (GBM), the most aggressive type of brain cancer in adults. We show that small molecule inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ab5b4735f4d38818e0308b709f2c1e
https://doi.org/10.1101/467654
https://doi.org/10.1101/467654
Autor:
Andrew N Holding, Edith M. Ross, Jennifer Williams, Florian Markowetz, Mihaela Lorger, Lee D. Roberts, Euan S. Polson, Hollie B. S. Griffiths, Christopher Abbosh, Verena Kuchler, Stephane Ballereau, Heiko Wurdak, Shoutian Zhu, Paul Chumas, Simon J. Allison, Eulashini Chuntharpursat-Bon, Ryan K. Mathew, Alastair Droop, Hao Shao, Adam J. Davies, Jason E. Gestwicki, Barbara da Silva, Robin S. Bon, Hester A. Beard, Anjana Patel, Susan C Short
Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain cancer. We showed that the synthetic small-molecule KHS101 prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da69000f2995632289b3b1ed5a069a53
https://eprints.whiterose.ac.uk/135396/1/Polson_et_al_2018_AAV.pdf
https://eprints.whiterose.ac.uk/135396/1/Polson_et_al_2018_AAV.pdf
Autor:
Susan C Short, Elizabeth S. Appleton, Gemma Migneco, David Taggart, Simon Thomson, Gerard J. Nuovo, Lucy F. Stead, Sergio A. Quezada, Samantha J. Turnbull, Adel Samson, Philip van Hille, Richard G. Vile, Julia V. Cockle, D. Beirne, Fiona Collinson, Fiona Errington-Mais, Karen Scott, Peter Selby, Euan S. Polson, Kevin J. Harrington, Erica B. Wilson, Heiko Wurdak, Martin Fuller, Stephen Griffin, Jill Thompson, Timothy Kottke, Hardev Pandha, Gnanamurthy Sivakumar, Chris Twelves, Ailsa Rose, Christy Ralph, Andrew Furness, Elizabeth Ilett, Robert Corns, Emma West, D. Alan Anthoney, Matthew C. Coffey, Ryan K. Mathew, Alan Melcher
Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor response and patient survival are determined by tumor programmed death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4899fce1ad145ea879d424f0b5ba845
Autor:
Claire Taylor, Paul Chumas, Barbara da Silva, Daniel Tams, Jennifer Williams, James T. Rutka, Susan C Short, Stephane Ballereau, Euan S. Polson, Gary Shaw, Florian Markowetz, Ryan K. Mathew, Heiko Wurdak, Orla O'Shea, Christian A. Smith
Publikováno v:
Neuro-Oncology. 20:vi273-vi274
BACKGROUND: Dysregulated, stem cell-like self-renewal has been implicated in glioma treatment resistance and tumour recurrence. Drugs that eliminate tumour cells possessing this malignant characteristic are urgently needed. It remains, however, an ex