Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Etzer Darout"'
Publikováno v:
Phosphodiesterases and Their Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ae2d55b3c75cf7b959080d95b8d303
https://doi.org/10.1002/9783527682348.ch04
https://doi.org/10.1002/9783527682348.ch04
Publikováno v:
Synthesis. 45:2481-2484
A detailed investigation of the preparation of 1-methylcyclopropanol via the Kulinkovich reaction is presented. Reaction and workup parameters were optimized to provide a reproducible procedure for the synthesis of multigram quantities of 1-methylcyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b62f86ca60c18815063af3cbd1f3c68
https://doi.org/10.1055/s-0033-1338504
https://doi.org/10.1055/s-0033-1338504
Autor:
Brian P. Rempel, Dona C. Love, Spencer Knapp, Paul R. Rablen, Stephen G. Withers, Mohannad Abdo, John A. Hanover, Etzer Darout, Eun Ju Kim
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:7058-7064
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469d4cea381498d1a474f9d923080bcf
https://doi.org/10.1016/j.bmc.2010.08.010
https://doi.org/10.1016/j.bmc.2010.08.010
Autor:
Arindrajit Basak, Etzer Darout
Publikováno v:
Tetrahedron Letters. 51:2998-3001
An efficient approach to a oxa-azabicyclo[3.2.1] derivatives has been achieved via a double-Mannich reaction of N,N-bis(methoxymethyl)-1-phenylethanamine with symmetrical and unsymmetrical ketones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c336950096a65a8a70563ca8ee9062c8
https://doi.org/10.1016/j.tetlet.2010.03.123
https://doi.org/10.1016/j.tetlet.2010.03.123
Autor:
Spencer Knapp, Etzer Darout
Publikováno v:
Tetrahedron Letters. 43:6075-6078
Oxidation of GlcNAc thiazoline in the presence of an alcohol affords no glycosidation products, but rather the alkyl α-GlcNAc 1-C-sulfonate. E2 cleavage of the sulfonate ester and then O -deacetylation gives the α-GlcNAc 1-C-sulfonic acid, a new ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f0a70bfdff726cd8fabb3b147d6c1c0
https://doi.org/10.1016/s0040-4039(02)01218-2
https://doi.org/10.1016/s0040-4039(02)01218-2
Publikováno v:
Tetrahedron Letters. 52:1949-1951
The synthesis of two unprecedented regioisomeric oxospiropyrazole piperidine scaffolds is detailed. Their potential utility as templates for drug discovery is also exemplified. Chemical stability and solid state conformation were also evaluated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d084f2609742cbd0c1f7cf197f1cab
https://doi.org/10.1016/j.tetlet.2011.02.060
https://doi.org/10.1016/j.tetlet.2011.02.060
Publikováno v:
ChemInform. 45
A carefully designed process for the scalable synthesis of 1-methylcyclopropanol (III) is developed as well as the optimized conversion to the mixed carbonate (V).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1173b0eba7c6e63cb0c9033ef76d776b
https://doi.org/10.1002/chin.201406059
https://doi.org/10.1002/chin.201406059
Publikováno v:
ChemInform. 43
Title compound (IV) is prepared as an unprecedented heterocyclic template for studies on the structure—activity relationship between the G-protein coupled receptor 119 (GPR119) and conformationally restricted ligands.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c179e97f5d26d8b45a6f7874c0a961c
https://doi.org/10.1002/chin.201242100
https://doi.org/10.1002/chin.201242100
Autor:
William R. Roush, Peter Hodder, Joshua Roth, Gregg B. Fields, Dmitriy Minond, Janelle L. Lauer, Qin Liu, Etzer Darout
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(23)
Matrix metalloproteinase-13 (MMP-13) has been implicated as the protease responsible for collagen degradation in cartilage during osteoarthritis (OA). Compounds that inhibit the metalloproteinase at the Zn binding site typically lack specificity amon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e3ced24db797c5f6f9c69114245173
https://pubmed.ncbi.nlm.nih.gov/22018790
https://pubmed.ncbi.nlm.nih.gov/22018790
Autor:
Michael P. DeNinno, Anthony R. Harris, Bruce Allen Lefker, Peter Cornelius, Etzer Darout, Daniel W. Kung, Lacey Samp, Paul D. Bonin, Sam Hornby, Kentaro Futatsugi, Bryan Li, E. D. Salter, Kim F. McClure, Jeffrey T. Kohrt, Ralph P. Robinson, Amit S. Kalgutkar, Ruduan Wang, Vincent Mascitti, Michael John Munchhof, Yue Chen, Cristiano Ruch Werneck Guimarães, Dianna E. Moore
Publikováno v:
Journal of medicinal chemistry. 54(6)
The synthesis and properties of the bridged piperidine (oxaazabicyclo) compounds 8, 9, and 11 are described. A conformational analysis of these structures is compared with the representative GPR119 ligand 1. These results and the differences in agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fe2f73c231954648f7f6a81214dd40
https://pubmed.ncbi.nlm.nih.gov/21361292
https://pubmed.ncbi.nlm.nih.gov/21361292