Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ettore J. Rastelli"'
Autor:
John S. Lazo, Elizabeth R. Sharlow, Robert Cornelison, Duncan J. Hart, Danielle C. Llaneza, Anna J. Mendelson, Ettore J. Rastelli, Nikhil R. Tasker, Charles N. Landen, Peter Wipf
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 969 (2021)
High grade serous ovarian cancer (OvCa) frequently becomes drug resistant and often recurs. Consequently, new drug targets and therapies are needed. Bioinformatics-based studies uncovered a relationship between high Protein Tyrosine Phosphatase of Re
Externí odkaz:
https://doaj.org/article/bd03bd9e93c14cfb8f63e736838dafd7
Autor:
John S. Lazo, Kelly N. Isbell, Sai Ashish Vasa, Danielle C. Llaneza, Ettore J. Rastelli, Peter Wipf, Elizabeth R. Sharlow
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 384:429-438
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7861cf91ab6d7a55e2423b858f85d111
https://doi.org/10.1124/jpet.122.001401
https://doi.org/10.1124/jpet.122.001401
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9281dce2cb2607a8776dcedeabda7f8b
https://doi.org/10.1096/fasebj.2022.36.s1.r2345
https://doi.org/10.1096/fasebj.2022.36.s1.r2345
Autor:
Danielle C. Llaneza, Peter Wipf, Nikhil R. Tasker, John S. Lazo, Duncan J. Hart, Robert Cornelison, Charles N. Landen, Anna J. Mendelson, Ettore J. Rastelli, Elizabeth R. Sharlow
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 969, p 969 (2021)
Volume 11
Issue 7
Biomolecules, Vol 11, Iss 969, p 969 (2021)
Volume 11
Issue 7
High grade serous ovarian cancer (OvCa) frequently becomes drug resistant and often recurs. Consequently, new drug targets and therapies are needed. Bioinformatics-based studies uncovered a relationship between high Protein Tyrosine Phosphatase of Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9736b37fc0ffabac3fcf1c0564574798
https://pubmed.ncbi.nlm.nih.gov/34209460
https://pubmed.ncbi.nlm.nih.gov/34209460
Autor:
Ettore J. Rastelli, Isabella K. Blanco, Sharon R. Garrott, Nikhil R. Tasker, James C. Burnett, John S. Lazo, Rebecca L. McCloud, Duncan J. Hart, Ku-Lung Hsu, Peter Wipf, Elizabeth R. Sharlow
Publikováno v:
J Pharmacol Exp Ther
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b24b4cdcfcfb425eb6a6bfdd68bcb71
https://doi.org/10.1124/jpet.119.262188
https://doi.org/10.1124/jpet.119.262188
Autor:
Nikhil R. Tasker, John S. Lazo, Isabella K. Blanco, Ettore J. Rastelli, Elizabeth R. Sharlow, James C. Burnett, Peter Wipf
Publikováno v:
Organic & Biomolecular Chemistry. 17:2448-2466
A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones to produce 7-iminothieno[3,2-c]pyridine-4,6(5H,7H)-diones has been developed, utilizing ambient air as the sole reactant. N-H Imines are formed as the major products, and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9942d7d2eb6b9f8d83309e4811c64c
https://doi.org/10.1039/c9ob00025a
https://doi.org/10.1039/c9ob00025a
Autor:
John S. Lazo, Kelly N. Isbell, Danielle C. Llaneza, Ettore J. Rastelli, Charles N. Landen, Peter Wipf, Elizabeth R. Sharlow
Publikováno v:
Cancer Research. 82:5500-5500
The objective of this study was twofold: (1) to examine the pharmacological effects of a potent, allosteric, small molecule inhibitor (KVX-053 or 7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione) of the oncogenic protein tyrosine phosphatase PT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d84a29f065de062036b70616388dde
https://doi.org/10.1158/1538-7445.am2022-5500
https://doi.org/10.1158/1538-7445.am2022-5500
Autor:
Isabella K. Blanco, John H. Bushweller, Elizabeth R. Sharlow, Peter Wipf, Kelley E. McQueeney, Ettore J. Rastelli, Mateusz P. Czub, Adam Boulton, Wladek Minor, Taber S. Maskrey, Nikhil R. Tasker, John S. Lazo
Publikováno v:
Mol Pharmacol
Protein tyrosine phosphatase (PTP) 4A3 is frequently overexpressed in human solid tumors and hematologic malignancies and is associated with tumor cell invasion, metastasis, and a poor patient prognosis. Several potent, selective, and allosteric smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c00eb00cd9f512f143b91f17c4ee66
https://pubmed.ncbi.nlm.nih.gov/33203716
https://pubmed.ncbi.nlm.nih.gov/33203716
Publikováno v:
Chem. 4:2228-2238
Summary The 3-alkoxy-1-N-toluenesulfonyl azopropene structural motif has been known in the context of the Eschenmoser-Tanabe fragmentation for over 50 years. It is derived from α-epoxy N-toluenesulfonyl hydrazones by deprotonation and epoxide ring o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46dcaf86f82c669ea436577cc10db53e
https://doi.org/10.1016/j.chempr.2018.08.007
https://doi.org/10.1016/j.chempr.2018.08.007
Autor:
Sara Sannino, Jeffrey L. Brodsky, Ettore J. Rastelli, Duncan J. Hart, Peter Wipf, Elizabeth R. Sharlow, John S. Lazo
Publikováno v:
Bioorg Med Chem Lett
We developed JMS-053, a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. Due to the emerging role of the unfolded protein response (UPR) in cancer pathology, we sought to identify derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceb15be8a07eaf3f744928dd8e1a402
https://doi.org/10.1016/j.bmcl.2021.128167
https://doi.org/10.1016/j.bmcl.2021.128167