Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ettore Giraldo"'
Autor:
C.A. Rizzi, Giovanni Battista Schiavi, Giorgio Moro, Ugo Cosentino, Ettore Giraldo, Myrna Gil Quintero, Marco Turconi
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 286:275-291
The conformational and electronic properties of 11 5-HT 3 receptor antagonists, were investigated to rationalize their biological activity. All compounds fulfill the previously reported geometrical requirements for the pharmacophore, although they sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b5c79771b53b0b2cbe0796e5fa7ea0c
https://doi.org/10.1016/0166-1280(93)87170-i
https://doi.org/10.1016/0166-1280(93)87170-i
Autor:
Rosamaria Micheletti, Myrna Gil Quintero, Luciano Maiocchi, Ettore Giraldo, Marco Turconi, Massimo Nicola, Arturo Donetti
Publikováno v:
ChemInform. 22
A series of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid esters and amides containing a basic azacyclo- or azabicycloalkyl moiety has been synthesized and evaluated for 5-HT3 antagonistic activity in a radioligand binding assay ([3H]ICS 20593
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15131cae1d7d1dbb7344df4c681a5fd0
https://doi.org/10.1002/chin.199104210
https://doi.org/10.1002/chin.199104210
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::697b1f76c8a63026aab0c0194f2464cb
https://doi.org/10.1002/chin.199513180
https://doi.org/10.1002/chin.199513180
Publikováno v:
Life Sciences. 51:583-592
The antagonistic properties of DAU 6285, an azabicycloalkyl benzimidazolone derivative, at putative 5-hydroxytryptamine4 (5-HT4) receptors were investigated in in vitro preparations of guinea-pig ileum and human atrium, in comparison to ICS 205-930.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174169d297e76e178812c6da1a3cd3e5
https://doi.org/10.1016/0024-3205(92)90227-g
https://doi.org/10.1016/0024-3205(92)90227-g
Autor:
Frederic Libert, Carine Maenhaut, Herbert Ladinsky, Claude Massart, J. Van Sande, Gilbert Vassart, Jacques Emile Dumont, Ettore Giraldo, Christiane Dinsart, E. Monferini
Publikováno v:
Biochemical and Biophysical Research Communications. 180:1460-1468
The cDNA of RDC4, a putative receptor of the G protein-coupled receptor family, has been cloned by PCR methodology. The primary structure of this receptor showed homology with the serotonin 5-HT1A receptor. In this work, RDC4 mRNA has been injected i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447b1992e445f360c9ad9ff933681644
https://doi.org/10.1016/s0006-291x(05)81360-9
https://doi.org/10.1016/s0006-291x(05)81360-9
Autor:
Rosamaria Micheletti, Massimo Nicola, Marco Turconi, Ettore Giraldo, Myrna Gil Quintero, Arturo Donetti, Luciano Maiocchi
Publikováno v:
Journal of Medicinal Chemistry. 33:2101-2108
A series of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid esters and amides containing a basic azacyclo- or azabicycloalkyl moiety has been synthesized and evaluated for 5-HT3 antagonistic activity in a radioligand binding assay ([3H]ICS 20593
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ba3e9201f711ee5396c6fed5aeea60
https://doi.org/10.1021/jm00170a009
https://doi.org/10.1021/jm00170a009
Publikováno v:
Journal of Receptor Research. 10:81-96
Guanylpirenzepine, a polar, non-quaternary analog of pirenzepine, exhibited a novel binding behavior in rat brain regions: in competition binding experiments against [3H]pirenzepine labeling the M1 receptor in membranes from cerebral cortex, hippocam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfba5f7194871b7bc2932d00b1d15955
https://doi.org/10.3109/10799899009064659
https://doi.org/10.3109/10799899009064659
Autor:
Franco Borsini, Giuseppe Bietti, Arturo Donetti, Ettore Giraldo, Marco Parenti, E. Monferini, G. Antonini
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 352
In the search for antidepressant agents with a rapid onset of action, we have found that compound BIMT 17 (1-[2-[4-(3-trifluoromethylphenyl)piperazin-1- yl]ethyl]benzimidazol-[1H]-2-one) shows a good affinity for cerebral cortical 5-HT1A (pKi = 7.72)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4ae251a32d5afb3bc092c4335ab5e3
https://doi.org/10.1007/bf00168557
https://doi.org/10.1007/bf00168557
Autor:
C.A. Rizzi, Ettore Giraldo, Riccardo Rodriguez y Baena, Marco Parenti, Paolo Gaetani, Andrea Zocchetti, E. Monferini
Publikováno v:
Life sciences. 52(9)
Recently, a 5-hydroxytryptamine (5-HT) receptor has been described, whose pharmacology was distinct from that of the already known serotonergic receptors, so that it has been called 5-HT 4 . Because the lack of a high affinity radioligand, the identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d57f998f57a1a56bc0ee41f7c8d686
https://pubmed.ncbi.nlm.nih.gov/8437506
https://pubmed.ncbi.nlm.nih.gov/8437506
Autor:
Marco Turconi, Aline Dumuis, H. Ansanay, C.A. Rizzi, Henri Gozlan, Herbert Ladinsky, Schiantarelli Pierino, Ettore Giraldo, Joël Bockaert, Michèle Sebben, E. Monferini
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 345(3)
Three chemical classes of serotonin 5-HT4 receptor agonists have been identified so far: 5-substituted indoles (e.g. 5-HT), benzamides (e.g. renzapride) and benzimidazolones (e.g. BIMU 8). In a search for 5-HT4 receptor antagonists, we have discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32a35e47b471cda9753a6224f864b01
https://pubmed.ncbi.nlm.nih.gov/1320204
https://pubmed.ncbi.nlm.nih.gov/1320204