Zobrazeno 1 - 10
of 502
pro vyhledávání: '"Ettore, Appella"'
Autor:
Kate Brown, Lisa M. Miller Jenkins, Daniel R. Crooks, Deborah R. Surman, Sharlyn J. Mazur, Yuan Xu, Bhargav S. Arimilli, Ye Yang, Andrew N. Lane, Teresa W-M. Fan, David S. Schrump, W. Marston Linehan, R. Taylor Ripley, Ettore Appella
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
TP53 is the most commonly mutated gene in cancer, and gain-of-function mutations have wide-ranging effects. Efforts to reactivate wild-type p53 function and inhibit mutant functions have been complicated by the variety of TP53 mutations. Identified f
Externí odkaz:
https://doaj.org/article/c07b755597a5468588906ab014a43c40
Autor:
Burhan Uyanik, Anastasia R. Goloudina, Aamir Akbarali, Bogdan B. Grigorash, Alexey V. Petukhov, Sunil Singhal, Evgeniy Eruslanov, Jeanne Chaloyard, Lisa Lagorgette, Tarik Hadi, Ekaterina V. Baidyuk, Hiroyasu Sakai, Lino Tessarollo, Bernhard Ryffel, Sharlyn J. Mazur, Frederic Lirussi, Carmen Garrido, Ettore Appella, Oleg N. Demidov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune r
Externí odkaz:
https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8
Autor:
Mohammad Arif Rahman, Massimiliano Bissa, Isabela Silva de Castro, Sabrina Helmold Hait, James D. Stamos, Farzana Bhuyan, Ruth Hunegnaw, Sarkis Sarkis, Anna Gutowska, Melvin N. Doster, Ramona Moles, Tanya Hoang, Lisa M. Miller Jenkins, Ettore Appella, David J. Venzon, Hyoyoung Choo-Wosoba, Timothy Cardozo, Marc M. Baum, Daniel H. Appella, Marjorie Robert-Guroff, Genoveffa Franchini
Publikováno v:
Nature Microbiology. 8:905-918
The human immunodeficiency virus epidemic continues in sub-Saharan Africa, and particularly affects adolescent girls and women who have limited access to antiretroviral therapy. Here we report that the risk of vaginal simian immunodeficiency virus (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::931e9a22803f35845e591812842c7541
https://doi.org/10.1038/s41564-023-01353-7
https://doi.org/10.1038/s41564-023-01353-7
Autor:
Tomer Cooks, Ioannis S. Pateras, Lisa M. Jenkins, Keval M. Patel, Ana I. Robles, James Morris, Tim Forshew, Ettore Appella, Vassilis G. Gorgoulis, Curtis C. Harris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received
Externí odkaz:
https://doaj.org/article/c7c38fedb00642b095bd023227041cc0
Autor:
Yu Yang, Jingyu Zhu, Matthew Hassink, Lisa M Miller Jenkins, Yanmin Wan, Daniel H Appella, Jianqing Xu, Ettore Appella, Xiaoyan Zhang
Publikováno v:
Emerging Microbes and Infections, Vol 6, Iss 1, Pp 1-8 (2017)
The strategy of simultaneously attacking multiple targets is worthy of exploration in the field of microbicide development to combat HIV-1 sequence diversity and minimize the transmission of resistant variants. A combination of S-acyl-2-mercaptobenza
Externí odkaz:
https://doaj.org/article/a6e854552b20465ba205e513c3ff8a94
Autor:
Victor Clausse, Yuhong Fang, Dingyin Tao, Harichandra D. Tagad, Hongmao Sun, Yuhong Wang, Surendra Karavadhi, Kelly Lane, Zhen-Dan Shi, Olga Vasalatiy, Christopher A. LeClair, Rebecca Eells, Min Shen, Samarjit Patnaik, Ettore Appella, Nathan P. Coussens, Matthew D. Hall, Daniel H. Appella
Publikováno v:
ACS Pharmacology & Translational Science. 5:993-1006
Wild-type P53-induced phosphatase 1 (WIP1), also known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a77d015aae85ddd0ddd8d9d272ae29f
https://doi.org/10.1021/acsptsci.2c00147
https://doi.org/10.1021/acsptsci.2c00147
Autor:
Mohammad Arif Rahman, Massimiliano Bissa, Isabela Silva de Castro, Sabrina Helmold Hait, James D. Stamos, Farzana Bhuyan, Ruth Hunegnaw, Sarkis Sarkis, Anna Gutowska, Melvin N. Doster, Ramona Moles, Tanya Hoang, Lisa M. Miller Jenkins, Ettore Appella, David J. Venzon, Hyoyoung Choo-Wosoba, Timothy Cardozo, Marc M. Baum, Daniel H. Appella, Marjorie Robert-Guroff, Genoveffa Franchini
Publikováno v:
Nature Microbiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77a3b0b797e890068cde0b366922e813
https://doi.org/10.1038/s41564-023-01412-z
https://doi.org/10.1038/s41564-023-01412-z
Autor:
Curtis C. Harris, Jun Yokota, Seiichi Takenoshita, Makoto Nagashima, Ettore Appella, Taro Yamashita, Izumi Horikawa, Kaori Fujita, Elisa A. Spillare, Kensuke Kumamoto
Supplementary Figure 1 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1eabed252b53ba42ee48ab35076054
https://doi.org/10.1158/0008-5472.22373703.v1
https://doi.org/10.1158/0008-5472.22373703.v1
Autor:
Curtis C. Harris, Jun Yokota, Seiichi Takenoshita, Makoto Nagashima, Ettore Appella, Taro Yamashita, Izumi Horikawa, Kaori Fujita, Elisa A. Spillare, Kensuke Kumamoto
Supplementary Figure 4 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bb53978acb70a6f84302482f46a14f
https://doi.org/10.1158/0008-5472.22373694
https://doi.org/10.1158/0008-5472.22373694
Autor:
Curtis C. Harris, Jun Yokota, Seiichi Takenoshita, Makoto Nagashima, Ettore Appella, Taro Yamashita, Izumi Horikawa, Kaori Fujita, Elisa A. Spillare, Kensuke Kumamoto
Supplementary Figure 3 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623903f127c9f5d0c143d71fce85b884
https://doi.org/10.1158/0008-5472.22373697
https://doi.org/10.1158/0008-5472.22373697