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Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Obesity and type 2 diabetes have both been associated with increased cancer risk and are becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and dyslipidemia are associated with both obesity and type 2 diabetes and hav
Externí odkaz:
https://doaj.org/article/0937af9bbfda43bdbf2d23f3c2d04153
Akademický článek
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Publikováno v:
Endocrine-Related Cancer. 30
Tumor uptake of exogenous cholesterol has been associated with the proliferation of various cancers. Previously, we and others have shown that hypercholesterolemia promotes tumor growth and silencing of the LDL receptor (LDLR) in high LDLR-expressing
Publikováno v:
In Diagnostic Microbiology & Infectious Disease November 2014 80(3):204-206
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2021)
Frontiers in Oncology, Vol 10 (2021)
Obesity and type 2 diabetes have both been associated with increased cancer risk and are becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and dyslipidemia are associated with both obesity and type 2 diabetes and hav
Autor:
Abora Ettela, Irwin J. Kurland, Nathan Kase, Yunping Qiu, Annie James, Chifei Kang, Tiffany Scully, Irini Markella Antoniou, Evren U. Azeloglu, Emily J. Gallagher, Nicholas J. Wong
Publikováno v:
Journal of the Endocrine Society
Obesity is associated with increased cancer risk and cancer-associated mortality1,2. Hypertriglyceridemia (HTG), a component of the metabolic syndrome which frequently co-exists with obesity, has been associated with increased breast cancer risk and
Autor:
Derek LeRoith, Irini Markella Antoniou, Nathan Kase, Tiffany Scully, Emily J. Gallagher, Chifei Kang, Gadi Shlomai, Abora Ettela, Annie James, Teresa L. Wood
Publikováno v:
Journal of the Endocrine Society
Systemic hyperinsulinemia is believed to be an important factor in the progression of a number of cancers, including breast cancer by activating the insulin receptor (IR) signaling cascade in the tumor cells. The IR is expressed in two isoforms, IR-A
Akademický článek
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Epigenetic modulation of β cells by interferon-α via PNPT1/mir-26a/TET2 triggers autoimmune diabetes
Autor:
Abora Ettela, Yaron Tomer, Zhengzi Yi, Lingguang Cui, Weijia Zhang, Mihaela Stefan-Lifshitz, Esra Karakose
Publikováno v:
JCI Insight. 4
Type 1 diabetes (T1D) is caused by autoimmune destruction of pancreatic β cells. Mounting evidence supports a central role for β cell alterations in triggering the activation of self-reactive T cells in T1D. However, the early deleterious events th