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Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways.

Autor: Feng S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. shengrui.feng@uhn.ca.; The First Affiliated Hospital of University of South China, Hengyang, Hunan, China. shengrui.feng@uhn.ca., Marhon SA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Sokolowski DJ; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada., D'Costa A; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Soares F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Mehdipour P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ishak C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Loo Yau H; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Ettayebi I; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Patel PS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Chen R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Liu J; The Cardiac Development and Early Intervention Unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China., Zuzarte PC; Ontario Institute for Cancer Research, Toronto, ON, Canada., Ho KC; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada., Ho B; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Ning S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Huang A; The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Arrowsmith CH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada., Simpson JT; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. daniel.decarvalho@uhnresearch.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. daniel.decarvalho@uhnresearch.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 29; Vol. 15 (1), pp. 9321. Date of Electronic Publication: 2024 Oct 29.