Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Etsushi Kuroda"'
Autor:
Eigo Kawahara, Kota Senpuku, Yoshino Kawaguchi, Shinya Yamamoto, Koubun Yasuda, Etsushi Kuroda, Noriko Ouji-Sageshima, Toshihiro Ito, Toshiro Hirai, Takehiko Shibata, Yasuo Yoshioka
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract The G protein expressed on the surface of respiratory syncytial virus (RSV) is important for adhesion to host cells and as a vaccine target antigen. The corresponding vaccines can effectively eliminate RSV. However, they exacerbate pulmonary
Externí odkaz:
https://doaj.org/article/dee15a537fd646bda03e2cb632193486
Autor:
Tomoya Sagawa, Takamichi Ichinose, Akiko Honda, Etsushi Kuroda, Raga Ishikawa, Natsuko Miyasaka, Megumi Nagao, Tomoaki Okuda, Yutaka Kawahito, Hirohisa Takano
Publikováno v:
Environment International, Vol 194, Iss , Pp 109178- (2024)
Asian sand dust (ASD), a significant desert sand dust, contains sub-2.5 µm fine particles and adversely affects human health, particularly exacerbating respiratory diseases. Despite this, the intricate physiological responses triggered by inhaled AS
Externí odkaz:
https://doaj.org/article/1b4ad3b033fc4cfab4cffdedb5671663
Autor:
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J. Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113981- (2024)
Summary: Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopol
Externí odkaz:
https://doaj.org/article/f22ab996a6a3412b82cc9ee0414c17dd
Autor:
Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto, Mayda Gursel, Seza Ozen, Etsushi Kuroda, Cevayir Coban, Ken J. Ishii
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, DMXAA reached phase III in lung cancer cli
Externí odkaz:
https://doaj.org/article/96d6c342ff5a4b34983c9c8d51741ae6
Autor:
Tomoyuki Otsuka, Sumiyuki Nishida, Takayuki Shibahara, Burcu Temizoz, Masanari Hamaguchi, Takayuki Shiroyama, Keiko Kimura, Kotaro Miyake, Haruhiko Hirata, Yumiko Mizuno, Mayu Yagita, Yusuke Manabe, Etsushi Kuroda, Yoshito Takeda, Hiroshi Kida, Ken J. Ishii, Atsushi Kumanogoh
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Cytosine-phosphate-guanine oligodeoxynucleotide (CpG ODN) (K3)—a novel synthetic single-stranded DNA immune adjuvant for cancer immunotherapy—induces a potential Th1-type immune response against cancer cells. We conducted a ph
Externí odkaz:
https://doaj.org/article/8812c8d7ce2f4eff8b8439c505989aa3
Autor:
Teppei Matsuda, Kazuki Misato, Shigeyuki Tamiya, Yasuhiro Akeda, Ikuhiko Nakase, Etsushi Kuroda, Shokichi Takahama, Motohiro Nonaka, Takuya Yamamoto, Michiko N. Fukuda, Yasuo Yoshioka
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105324- (2022)
Summary: Efficient delivery of subunit vaccines to dendritic cells (DCs) is necessary to improve vaccine efficacy, because the vaccine antigen alone cannot induce sufficient protective immunity. Here, we identified DC-targeting peptides using a phage
Externí odkaz:
https://doaj.org/article/8ae2bff502fd46518ef4bb26b97de9d1
Autor:
Kou Hioki, Tomoya Hayashi, Yayoi Natsume-Kitatani, Kouji Kobiyama, Burcu Temizoz, Hideo Negishi, Hitomi Kawakami, Hiroyuki Fuchino, Etsushi Kuroda, Cevayir Coban, Nobuo Kawahara, Ken J. Ishii
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adjuvants are important vaccine components, composed of a variety of chemical and biological materials that enhance the vaccine antigen-specific immune responses by stimulating the innate immune cells in both direct and indirect manners to produce a
Externí odkaz:
https://doaj.org/article/fa80452d68f5493aa0a8cbec10a8eb4d
Autor:
Shigeyuki Tamiya, Eisuke Yoshikawa, Monami Ogura, Etsushi Kuroda, Koichiro Suzuki, Yasuo Yoshioka
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT Mycoplasma pneumoniae (Mp) residing extracellularly in the respiratory tract is the primary cause of bacterial community-acquired pneumonia in humans. However, the detailed pathological mechanism of Mp infection, especially inflammation in t
Externí odkaz:
https://doaj.org/article/21ae2f14cf224f4abcd9deeb882257cc
Autor:
Minori Nakatani-Kusakabe, Koubun Yasuda, Michio Tomura, Makoto Nagai, Kiyofumi Yamanishi, Etsushi Kuroda, Nobuo Kanazawa, Yasutomo Imai
Publikováno v:
JID Innovations, Vol 1, Iss 3, Pp 100035- (2021)
We previously generated a transgenic mouse line expressing skin-specific IL-33 (IL33tg mice) and showed that IL-33 elicits group 2 innate lymphoid cell (ILC2)–dependent atopic dermatitis–like skin inflammation. ILC2s are believed to be tissue-res
Externí odkaz:
https://doaj.org/article/47999b609c34474da18fbdff7f36a71f
Autor:
Koubun Yasuda, Etsushi Kuroda
Publikováno v:
Immunological Medicine, Vol 42, Iss 4, Pp 148-155 (2019)
Infections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues. Eosinophils are not effective against all
Externí odkaz:
https://doaj.org/article/5b04d743a60e49a195a245e3a24834e9