Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Etsuo Ohshima"'
Autor:
Eiki Kanemaru, Yusuke Miyazaki, Eizo Marutani, Mariko Ezaka, Shunsaku Goto, Etsuo Ohshima, Donald B. Bloch, Fumito Ichinose
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102620- (2023)
Background: Delayed paraplegia is a devastating complication of thoracoabdominal aortic surgery. Hydrogen sulfide (H2S) was reported to be protective in a mouse model of spinal cord ischemia and the beneficial effect of H2S has been attributed to pol
Externí odkaz:
https://doaj.org/article/06b7312f1f15406480e26f73654ea379
Autor:
Shoichiro Tomonaga, Ikumi Shimokawa, Takahiro Nuno, Hiroaki Ishimaru, Takahiro Isobe, Etsuo Ohshima, Shinji Kitagaki
Publikováno v:
Journal of Organic Chemistry; 8/2/2024, Vol. 89 Issue 15, p10946-10952, 7p
Autor:
Mariko Ezaka, Eizo Marutani, Yusuke Miyazaki, Eiki Kanemaru, Martin K. Selig, Sophie L. Boerboom, Katrina F. Ostrom, Anat Stemmer-Rachamimov, Donald B. Bloch, Gary J. Brenner, Etsuo Ohshima, Fumito Ichinose
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2122 (2022)
Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontan
Externí odkaz:
https://doaj.org/article/fa29d65e66d94a90817c05e453bffe5a
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 2, Pp 310-317 (2008)
Inhibitors of PDE4 (cAMP-specific phosphodiesterase) induce side effects, including nausea and emesis, that limit their therapeutic potential. We investigated the function of two catalytically active conformations of PDE4 (a low-affinity conformer de
Externí odkaz:
https://doaj.org/article/45dc254497d24e6bb7a4e41e19d4e437
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 2, Pp 310-317 (2008)
Inhibitors of PDE4 (cAMP-specific phosphodiesterase) induce side effects, including nausea and emesis, that limit their therapeutic potential. We investigated the function of two catalytically active conformations of PDE4 (a low-affinity conformer de
Autor:
Etsuo Ohshima, Hiromasa Miyaji, Hideki Mimura, Toshihide Ikemura, Akira Karasawa, Haruhiko Manabe, Masatsugu Sawada, Eiichi Fuse, Kimihisa Ueno, Osamu Kotera, Satoshi Tashiro
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 314:244-251
Prostaglandin (PG) D2, a major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is known to induce activation and chemotaxis in eosinophils, basophils, and T helper 2 (Th2) lymphocytes via a newly identified PGD2 recept
Publikováno v:
Folia Pharmacologica Japonica. 123:335-348
Due to the prevalence of allergic diseases such as bronchial asthma, allergic rhinoconjunctivitis and dermallergosis, efforts at the discovery of novel and effective medications for prevention and treatment of these conditions have been reinforced. R
Autor:
Toshihiko Kaise, Takashi Yamazaki, Etsuo Ohshima, Akimichi Mukouyama, Ken-ichi Hayashi, Satoshi Kobayashi, Kenji Ohmori
Publikováno v:
Japanese Journal of Pharmacology. 88:379-397
Olopatadine hydrochloride (olopatadine, 11-[(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride) is a novel antiallergic/histamine H1-receptor antagonistic drug that was synthesized and evaluated in our lab
Autor:
Fumio Suzuki, Yukio Sasaki, Takeaki Miyamae, Nobutaka Arai, Nobuya Furukawa, Yoshimi Misu, Kiyohide Fujita, Yoshio Goshima, Etsuo Ohshima
Publikováno v:
Neuroscience Letters. 299:213-216
In rat striata, DOPA released is a causal factor for glutamate release and resultant delayed neuron death by four-vessel occlusion. Nanomolar DOPA cyclohexyl ester (CHE), a potent and relatively stable competitive DOPA antagonist, protects these even
Autor:
Minako Shimizu, Yoshio Goshima, Yoshimi Misu, Koichiro Kawashima, Tomomi Shibata, Fumio Suzuki, Etsuo Ohshima, Takeaki Miyamae
Publikováno v:
Life Sciences. 64:1045-1054
L-DOPA is probably a transmitter and/or modulator in the central nervous system (1). L-DOPA methyl ester (DOPA ME) is a competitive L-DOPA antagonist. However, it remains to be clarified whether there exist L-DOPAergic receptors. In Xenopus laevis oo