Výsledky vyhledávání - "Etsuko Usuki"

In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450

Autor: Andrew Parkinson, Etsuko Usuki, Brian W. Ogilvie, Phyllis Yerino

Publikováno v: Drug-Drug Interactions ISBN: 9780429131967

Victims are those drugs whose clearance is predominantly determined by a single route of elimination, such as metabolism by a single cytochrome P450 (CYP) enzyme. This chapter focuses on in vitro reaction phenotyping and CYP inhibition. A wide range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::619c8ec61412d5171b542eaf065ff119
https://doi.org/10.1201/9780429131967-7

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Use of Enzyme Inhibitors to Evaluate the Conversion Pathways of Ester and Amide Prodrugs: A Case Study Example with the Prodrug Ceftobiprole Medocaril

Autor: Brian W. Ogilvie, Andrew Parkinson, Fred Tonelli, Etsuko Usuki, Anne Schmitt-Hoffmann, Dawn Baumgardner, Jennifer Skibbe, Mark D. Johnson, Gary Eichenbaum, Jeff Holsapple

Publikováno v: Journal of Pharmaceutical Sciences. 101:1242-1252

An approach was developed that uses enzyme inhibitors to support the assessment of the pathways that are responsible for the conversion of intravenously administered ester and amide prodrugs in different biological matrices. The methodology was appli

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https://doi.org/10.1002/jps.22816

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An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes

Autor: Dan Brobst, Brandy L. Paris, Florence Ndikum-Moffor, Etsuko Usuki, Andrew Parkinson, Jennifer Skibbe, Ivan King, Brian W. Ogilvie, Alaa-Eldin F Nassar, Lois J. Haupt, Rebecca Campbell

Publikováno v: Drug Metabolism and Disposition. 37:1922-1930

Laromustine (VNP40101M, also known as Cloretazine) is a novel sulfonylhydrazine alkylating (anticancer) agent. Laromustine generates two types of reactive intermediates: 90CE and methylisocyanate. When incubated with rat, dog, monkey, and human liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f609c798bda1ce2ce5e1408090a5ac
https://doi.org/10.1124/dmd.109.027516

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CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

Autor: Oliver T. Parkinson, Mary F. Paine, James L. Allen, Janelle Y. Saulter, Michael Hall, David W. Boykin, James Edwin Hall, Greg J. Loewen, Richard R. Tidwell, Chad E. Stephens, Etsuko Usuki, Darryl C. Zeldin, Yen Ling Cheung, Arlene S. Bridges, Andrew Parkinson, Michael Zhuo Wang

Publikováno v: Drug Metabolism and Disposition. 34:1985-1994

DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antiparasitic diamidine DB75 [2,5-bis(4-amidinophenyl) furan] by sequential oxidative O-demethylation and reductive N-dehydroxylation reactions. Previous work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd79286dadf2572a54ca93760fabd03
https://doi.org/10.1124/dmd.106.010587

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Metabolic studies on haloperidol and its tetrahydropyridinyl dehydration product (HPTP) in C57BL/6 mouse brain preparations

Autor: Cornelis J. Van der Schyf, Kay Castagnoli, Jeffrey R. Bloomquist, Etsuko Usuki, Ethan R. Freeborn, Neal Castagnoli

Publikováno v: Neurotoxicity Research. 4:51-58

The neuroleptic agent haloperidol (HP) and its tetrahydropyridinyl dehydration product HPTP are biotransformed by humans, baboons and rodents to the HP pyridinium (HPP(+)) and reduced HP pyridinium (RHPP(+)) species, potential neurotoxic metabolites

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https://doi.org/10.1080/10298420290007628

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Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: Is HPTP an intermediate?

Autor: Gilles L. Fraser, Kathryn M. Avent, Richard R. Riker, Susan Pond, Cornelis J. Van der Schyf, Etsuko Usuki

Publikováno v: Life Sciences. 61:2383-2390

The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3daec39507991633fb8a0a341eb8a520
https://doi.org/10.1016/s0024-3205(97)00955-7

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Studies on the metabolism of haloperidol (HP): The role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP

Autor: Miyoshi Fukui, Fumiyo Kasuya, K. Igarashi, Etsuko Usuki, Neal Castagnoli

Publikováno v: Life Sciences. 57:2439-2446

The levels of haloperidol (HP) and its pyridinium metabolite HPP+ were estimated in plasma and brain tissues of rats treated i.p. with HP (10 mg/kg). HP and HPP+ levels in plasma decreased linearly during the 0-3 hour period following drug administra

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https://doi.org/10.1016/0024-3205(95)02240-5

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Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression

Autor: Andrew Parkinson, L M Kao, James B Parker, Angelique Leone, Kelley Michael F, Alex Nie, Mark D. Johnson, Michael K. McMillian, Etsuko Usuki, Peter Lord

Publikováno v: Chemical research in toxicology. 20(4)

Felbamate is an antiepileptic drug that is associated with minimal toxicity in preclinical species such as rat and dog but has an unacceptable incidence of serious idiosyncratic reactions in man. Idiosyncratic reactions account for over half of toxic

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https://pubmed.ncbi.nlm.nih.gov/17381134

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Metabolism of haloperidol and its tetrahydropyridine dehydration product HPTP

Autor: Neal Castagnoli, Etsuko Usuki, C. J. Van Der Schyf

Publikováno v: Drug metabolism reviews. 30(4)

(1998). Metabolism of Haloperidol and Its Tetrahydropyridine Dehydration Product HPTP. Drug Metabolism Reviews: Vol. 30, No. 4, pp. 809-826.

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https://pubmed.ncbi.nlm.nih.gov/9844810

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