Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Etsuko Sekino"'
Autor:
Akane Ishihara, Shigeru Tokita, Satoru Ito, Hiroshi Miyazoe, Masahiko Ito, Minoru Moriya, Kazuho Nakase, Kaori Kamijo, Hiroko Matsushita, Minoru Kameda, Kouta Masutani, Etsuko Sekino, Akihiro Takezawa, Norihiro Takenaga, Takehiro Fukami, Akio Kanatani, Nagaaki Sato, Makoto Ando, Junko Ito, Takao Suzuki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5339-5345
Optimization of the lead 2a led to the identification of a novel diarylketoxime class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Our focus was directed toward improvement of hERG activity and metabolic stability. The representa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4d7fb37b33c5d2a3dbe6fc37052a6d
https://doi.org/10.1016/j.bmcl.2009.07.132
https://doi.org/10.1016/j.bmcl.2009.07.132
Autor:
Norihiro Takenaga, Ryo Yoshimoto, Takashi Fujimura, Yuko Mitobe, Takeshi Tanaka, Yasuhisa Miyamoto, Akane Ishihara, Shigeru Tokita, Etsuko Sekino, Sayaka Ito, Takehiro Fukami, Takahide Sasaki, Shiho Ishikawa, Nagaaki Sato, Takashi Mizutani, Tsuyoshi Nagase
Publikováno v:
Journal of Medicinal Chemistry. 51:4780-4789
A new series of quinazolinone derivatives was synthesized and evaluated as nonimidazole H 3 receptor inverse agonists. 2-Methyl-3-(4-[[3-(1-pyrrolidinyl)propyl]oxy]phenyl)-5-(trifluoromethyl)-4(3 H)-quinazolinone ( 1) was identified as a promising de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f62c3b85a897c2258549ea0a21346b5
https://doi.org/10.1021/jm8003834
https://doi.org/10.1021/jm8003834
Publikováno v:
The Journal of Organic Chemistry. 69:2760-2767
(-)-Quinine-catalyzed intramolecular oxo-Michael addition (IMA) of 7-hydroxy-5-methoxy-8-tigloylcoumarins was developed for the enantioselective construction of 2,3-dimethyl-4-chromanone systems in the context of the asymmetric synthesis of anti-HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d23de9376c6ffbc2c843926ceeff76
https://doi.org/10.1021/jo035753t
https://doi.org/10.1021/jo035753t
Autor:
Etsuko Sekino, Akio Kanatani, Hisashi Iwaasa, Masahiko Ito, Minoru Moriya, Akane Ishihara, Junko Ito, Yuji Haga, Norikazu Ohtake, Makoto Ando
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy)phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl)phenyl]e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1f099231e52a67ac8afa97c6a90ccb
https://pubmed.ncbi.nlm.nih.gov/19632840
https://pubmed.ncbi.nlm.nih.gov/19632840
Autor:
Takehiro Fukami, Hisashi Iwaasa, Keita Nagai, Etsuko Sekino, Takuya Suga, Akio Kanatani, Toshihiro Sakamoto, Makoto Ishikawa, Nagaaki Sato, Masahiko Ito, Hidekazu Takahashi, Minoru Moriya, Yumiko Imai, Shigeru Tokita, Takao Suzuki, Akane Ishihara, Hiroyuki Kishino
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(11)
Optimization of high-throughput screening hit 1a led to the identification of a novel spiro-piperidine class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Compound 3c was identified as a highly potent and selective MCH-1R antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f0b40987aa1a2273688f6eee24d105
https://pubmed.ncbi.nlm.nih.gov/19403308
https://pubmed.ncbi.nlm.nih.gov/19403308
Autor:
Takashi Mizutani, Norihiro Takenaga, Shigeru Tokita, Takeshi Tanaka, Yasuhisa Miyamoto, Nagaaki Sato, Tsuyoshi Nagase, Akane Ishihara, Sayaka Ito, Shiho Ishikawa, Ryo Yoshimoto, Yuko Mitobe, Etsuko Sekino
Publikováno v:
Journal of medicinal chemistry. 51(21)
A series of structurally constrained derivatives of the potent H 3 inverse agonist 1 was designed, synthesized, and evaluated as histamine H 3 receptor inverse agonists. As a result, the N-cyclobutylpiperidin-4-yloxy group as in 2f was identified as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b822ed718329d0909c30f70c268466b
https://pubmed.ncbi.nlm.nih.gov/18841880
https://pubmed.ncbi.nlm.nih.gov/18841880
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88994ec35cf4141cdb3c42b553f6339e
https://doi.org/10.1002/chin.200433235
https://doi.org/10.1002/chin.200433235
Autor:
Tsuyoshi Nagase, Takashi Mizutani, Etsuko Sekino, Shiho Ishikawa, Sayaka Ito, Yuko Mitobe, Yasuhisa Miyamoto, Ryo Yoshimoto, Takeshi Tanaka, Akane Ishihara, Norihiro Takenaga, Shigeru Tokita, Nagaaki Sato
Publikováno v:
Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 21, p6889-6901, 13p
Autor:
Tsuyoshi Nagase, Takashi Mizutani, Shiho Ishikawa, Etsuko Sekino, Takahide Sasaki, Takashi Fujimura, Sayaka Ito, Yuko Mitobe, Yasuhisa Miyamoto, Ryo Yoshimoto, Takeshi Tanaka, Akane Ishihara, Norihiro Takenaga, Shigeru Tokita, Takehiro Fukami, Nagaaki Sato
Publikováno v:
Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 15, p4780-4789, 10p