Zobrazeno 1 - 10
of 673
pro vyhledávání: '"Etomoxir"'
Autor:
Jin-Kyoung Shim, Seonah Choi, Seon-Jin Yoon, Ran Joo Choi, Junseong Park, Eun Hee Lee, Hye Joung Cho, Suji Lee, Wan-Yee Teo, Ju Hyung Moon, Hyun Sil Kim, Eui Hyun Kim, Jae-Ho Cheong, Jong Hee Chang, Jong In Yook, Seok-Gu Kang
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma (GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects in GBM, which involve interr
Externí odkaz:
https://doaj.org/article/81126cca355a41108090049fa85eea74
Akademický článek
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Autor:
Klaus Wunderling, Christina Leopold, Isabell Jamitzky, Mohamed Yaghmour, Fabian Zink, Dagmar Kratky, Christoph Thiele
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101150- (2021)
Objective: Medium-chain fatty acids (MCFAs) play an increasing role in human nutrition. In the liver, one fraction is used for synthesis of MCFA-containing triacylglycerol (MCFA-TG), and the rest is used for oxidative energy production or ketogenesis
Externí odkaz:
https://doaj.org/article/55757cdfc7b44855b84f02becf6f3fac
Autor:
Douglas Lemos, Thaís Oliveira, Larissa Martins, Vitória Ramos de Azevedo, Mariana Figueiredo Rodrigues, Luisa Andrea Ketzer, Franklin David Rumjanek
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/dd6f12ae3cd843a0ace0ab2416ef7690
Autor:
Douglas Lemos, Thaís Oliveira, Larissa Martins, Vitória Ramos de Azevedo, Mariana Figueiredo Rodrigues, Luisa Andrea Ketzer, Franklin David Rumjanek
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Tumor cells exhibit rewired metabolism. We carried out comparative analyses attempting to investigate whether metabolic reprograming could be measured by isothermal microcalorimetry. Intact metastatic cell lines of tongue cell carcinoma, human and mu
Externí odkaz:
https://doaj.org/article/01beaff94af341ba8fc2d2edafbf99b7
Autor:
Anthony E. Jones, Nataly J. Arias, Aracely Acevedo, Srinivasa T. Reddy, Ajit S. Divakaruni, David Meriwether
Publikováno v:
Metabolites, Vol 11, Iss 8, p 468 (2021)
Coenzyme A (CoA) is an essential cofactor for dozens of reactions in intermediary metabolism. Dysregulation of CoA synthesis or acyl CoA metabolism can result in metabolic or neurodegenerative disease. Although several methods use liquid chromatograp
Externí odkaz:
https://doaj.org/article/83c4dad918004a8aa58beb5df7d542d5
Akademický článek
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Publikováno v:
JBMR Plus, Vol 3, Iss 3, Pp n/a-n/a (2019)
ABSTRACT Multiple myeloma (MM) accounts for 13% to 15% of all blood cancers and is characterized by the proliferation of malignant cells within the bone marrow (BM). Despite important advances in treatment, most patients become refractory and relapse
Externí odkaz:
https://doaj.org/article/b56780573a3b481cae0bb372a761a132
Publikováno v:
Rheumatology. 61:3071-3081
Objective To identify the role of fatty acid binding protein 3 (FABP3) in vascular fibrosis in Takayasu’s arteritis (TAK) and to explore the underlying molecular mechanism. Methods The expression of FABP3 and extracellular matrix proteins (ECMs) we
Autor:
Nerea Urruticoechea, Emil W. Westi, Jens V. Andersen, Blanca I. Aldana, Emil Jakobsen, Karin Borges
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-13 (2021)
Molecular Brain
Andersen, J V, Westi, E W, Jakobsen, E, Urruticoechea, N, Borges, K & Aldana, B I 2021, ' Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply ', Molecular Brain, vol. 14, no. 1, 132 . https://doi.org/10.1186/s13041-021-00842-2
Molecular Brain
Andersen, J V, Westi, E W, Jakobsen, E, Urruticoechea, N, Borges, K & Aldana, B I 2021, ' Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply ', Molecular Brain, vol. 14, no. 1, 132 . https://doi.org/10.1186/s13041-021-00842-2
The medium-chain fatty acids octanoic acid (C8) and decanoic acid (C10) are gaining attention as beneficial brain fuels in several neurological disorders. The protective effects of C8 and C10 have been proposed to be driven by hepatic production of k