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pro vyhledávání: '"Etienne Rauber"'
Autor:
Patrizio Mattei, Joerg Huwyler, Patrick Di Giorgio, Buelent Kocer, Robert Narquizian, Etienne Rauber, Bernd Michael Loeffler, Alexander Macdonald, Michael Hennig, Elena Sebokova, Markus Boehringer, Holger Fischer, Bernd Kuhn, Urs Sprecher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1109-1113
Design, synthesis, and SAR are described for a class of DPP-IV inhibitors based on aminobenzo[a]quinolizines with non-aromatic substituents in the S1 specificity pocket. One representative thereof, carmegliptin (8p), was chosen for clinical developme