Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Etienne Régulier"'
Autor:
Delphine Charvin, Emmanuel Roze, Valérie Perrin, Carole Deyts, Sandrine Betuing, Christiane Pagès, Etienne Régulier, Ruth Luthi-Carter, Emmanuel Brouillet, Nicole Déglon, Jocelyne Caboche
Publikováno v:
Neurobiology of Disease, Vol 29, Iss 1, Pp 22-29 (2008)
Huntington’s disease (HD) results from an abnormal polyglutamine extension in the N-terminal region of the huntingtin protein. This mutation causes preferential degeneration of striatal projection neurons. We previously demonstrated, in vitro, that
Externí odkaz:
https://doaj.org/article/7225abf79e784da8b3a8b3b38f8aef90
Autor:
Linda Anne Elliston, Roger Moser, Darlene R. Goldstein, Ruth Luthi-Carter, Ayshe Ana Beesen, Lionel Breuillaud, Mariana de Fatima Silva Santos, Lesley Jones, Etienne Régulier, Jinho Kim, David Taylor, Meredith Dixon, Robert J. Ferrante
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience
We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with increased expression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e6e8fded0f4f36532de8f0ec2f580a
Autor:
Paolo Paganetti, Etienne Régulier, David E. Housman, Vanita Chopra, Ruth A. Bodner, Dorothee Abramowski, Graeme Bilbe, Scott Zeitlin, Corinna Klein, Jonathan H. Fox, Kimberly B. Kegel, Marian DiFiglia, Andreas Weiss, Steven M. Hersch, Muriel Stefani, Stephan Grueninger, H. Diana Rosas, Miriam Bibel
Publikováno v:
Analytical Biochemistry. 395:8-15
The genetic mutation causing Huntington's disease is a polyglutamine expansion in the huntingtin protein where more than 37 glutamines cause disease by formation of toxic intracellular fragments, aggregates, and cell death. Despite a clear pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08369eb70968506288e76576063e5069
https://doi.org/10.1016/j.ab.2009.08.001
https://doi.org/10.1016/j.ab.2009.08.001
Autor:
Ozgun Gokce, Nikita Rudinskiy, Nicole Déglon, Ayshe Ana Beesen, Etienne Régulier, Ruth Luthi-Carter, Yoshio A. Kaneko
Publikováno v:
Journal of Neurochemistry. 111:460-472
Hippocalcin is a neuronal calcium sensor protein previously implicated in regulating neuronal viability and plasticity. Hippocalcin is the most highly expressed neuronal calcium sensor in the medium spiny striatal output neurons that degenerate selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab7dfcb2bd12457364a7701bff3a868
https://doi.org/10.1111/j.1471-4159.2009.06344.x
https://doi.org/10.1111/j.1471-4159.2009.06344.x
Autor:
James Shorter, Susan Lindquist, Patrick Aebischer, Hilal A. Lashuel, Christophe Lo Bianco, Takeshi Iwatsubo, Etienne Régulier
Publikováno v:
Journal of Clinical Investigation. 118:3087-3097
Parkinson disease (PD) is characterized by dopaminergic neurodegeneration and intracellular inclusions of alpha-synuclein amyloid fibers, which are stable and difficult to dissolve. Whether inclusions are neuroprotective or pathological remains contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6a5fccf2dd5127b1864871e1a209db
https://doi.org/10.1172/jci35781
https://doi.org/10.1172/jci35781
Autor:
Nicole Déglon, Emmanuel Brouillet, Etienne Régulier, Valérie Perrin, Toufik Abbas-Terki, Raymonde Hassig, Ruth Luthi-Carter, Patrick Aebischer
Publikováno v:
Molecular Therapy. 15(5):903-911
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expansion of glutamine repeats in the huntingtin (htt) protein. Abnormal protein folding and the accumulation of mutated htt are hallmarks of HD neuropathology. Heat-sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7798d8d700a3678038c1b7fbaa22f960
Autor:
James P, Burke, Elke, Hunsche, Etienne, Régulier, Mitchell, Nagao, Paul, Buzinec, William, Drake Iii
Publikováno v:
The American journal of managed care. 21
This study assessed pulmonary hypertension (PH)-related hospitalizations, including readmissions, among US patients with pulmonary arterial hypertension (PAH), a rare disease characterized by high morbidity and premature mortality.Analysis of claims
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e951d5f818516272e02aee2a0e683a0
https://pubmed.ncbi.nlm.nih.gov/25734573
https://pubmed.ncbi.nlm.nih.gov/25734573
Autor:
Alexis Brice, Etienne Régulier, Patrick Aebischer, Frédéric Saudou, Emilie Colin, Nicole Déglon, Valérie Perrin, Alexandra Durr, Sandrine Humbert
Publikováno v:
European Journal of Neuroscience. 21:1478-1488
The insulin-like growth factor I (IGF-1)/Akt pathway plays a crucial role in Huntington's disease by phosphorylating the causative protein, polyQ-huntingtin, and abolishing its toxic properties [Humbert et al. (2002)Dev. Cell, 2, 831-837; Rangone et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd04fc9659b56a32df57ac9c22d46c5
https://doi.org/10.1111/j.1460-9568.2005.03985.x
https://doi.org/10.1111/j.1460-9568.2005.03985.x
Publikováno v:
Cancer Immunology, Immunotherapy. 51:645-654
Cytotoxic T cells can recognize and kill tumor cells that present peptides derived from tumor-associated antigens (TAA) on their surface when associated with major histocompatibility complex (MHC) class I molecules. However, immune responses to tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb65cf0fd04479402ed1a08f4c84abd
https://doi.org/10.1007/s00262-002-0314-2
https://doi.org/10.1007/s00262-002-0314-2
Autor:
Martine Marigliano, Dominique Roecklin, Valérie Calenda, Yves Poitevin, Stéphane Paul, Gilles Cauet, Etienne Régulier, Jacqueline Kintz, Catherine Ledoux, Horst Homann
Publikováno v:
Cancer Gene Therapy. 8:45-54
Based on the observation that the growth of solid tumors is dependent on the formation of new blood vessels, therapeutic strategies aimed at inhibiting angiogenesis have been proposed. A number of proteins with angiostatic activity have been describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161677a287ffbe2bcd98711082c5326f
https://doi.org/10.1038/sj.cgt.7700278
https://doi.org/10.1038/sj.cgt.7700278