Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Etienne Pays"'
Autor:
Etienne Pays
Publikováno v:
Kidney and Dialysis, Vol 4, Iss 2, Pp 126-143 (2024)
Apolipoprotein L1 (APOL1) nephropathy results from several podocyte dysfunctions involving morphological and motility changes, mitochondrial perturbations, inflammatory stress, and alterations in cation channel activity. I propose that this phenotype
Externí odkaz:
https://doaj.org/article/92c74571453a4986868c26867744081a
Autor:
Etienne Pays
Publikováno v:
Cells, Vol 13, Iss 24, p 2115 (2024)
The mammalian Apolipoprotein-L families (APOLs) contain several isoforms of membrane-interacting proteins, some of which are involved in the control of membrane dynamics (traffic, fission and fusion). Specifically, human APOL1 and APOL3 appear to con
Externí odkaz:
https://doaj.org/article/36fa0b32e4e043c388beb60f99183446
Autor:
Etienne Pays
Publikováno v:
Cells, Vol 13, Iss 20, p 1738 (2024)
Apolipoprotein-L1 (APOL1) is a membrane-interacting protein induced by inflammation, which confers human resistance to infection by African trypanosomes. APOL1 kills Trypanosoma brucei through induction of apoptotic-like parasite death, but two T. br
Externí odkaz:
https://doaj.org/article/794afcd4b12c49a2a94602d1cb5f5a80
Autor:
Laurence Lecordier, Paul Heo, Jonas H. Graversen, Dorle Hennig, Maria Kløjgaard Skytthe, Alexandre Cornet d’Elzius, Frédéric Pincet, David Pérez-Morga, Etienne Pays
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113528- (2023)
Summary: Apolipoproteins L1 and L3 (APOLs) are associated at the Golgi with the membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular myosin 2A. Either APOL1 C-terminal truncation (APOL1Δ) or APOL3 deletion (APOL3-KO [
Externí odkaz:
https://doaj.org/article/f14274957a20483d908e98fc48560d83
Autor:
Claire Valotteau, Andra C. Dumitru, Laurence Lecordier, David Alsteens, Etienne Pays, David Pérez-Morga, Yves F. Dufrêne
Publikováno v:
ACS Omega, Vol 5, Iss 33, Pp 20953-20959 (2020)
Externí odkaz:
https://doaj.org/article/610f45d5084c4d4b81c8b249f83b1077
Autor:
Laurence Lecordier, Sophie Uzureau, Gilles Vanwalleghem, Magali Deleu, Jean-Marc Crowet, Paul Barry, Barry Moran, Paul Voorheis, Andra-Cristina Dumitru, Yoshiki Yamaryo-Botté, Marc Dieu, Patricia Tebabi, Benoit Vanhollebeke, Laurence Lins, Cyrille Y. Botté, David Alsteens, Yves Dufrêne, David Pérez-Morga, Derek P. Nolan, Etienne Pays
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101476- (2020)
Summary: Human innate immunity to Trypanosoma brucei involves the trypanosome C-terminal kinesin TbKIFC1, which transports internalized trypanolytic factor apolipoprotein L1 (APOL1) within the parasite. We show that TbKIFC1 preferentially associates
Externí odkaz:
https://doaj.org/article/6a371ab7ad8949d99821c1fe7af3434e
Autor:
Sophie Uzureau, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H. Graversen, Fabrice Homblé, Pepe Ekulu Mfutu, Fanny Oliveira Arcolino, Ana Raquel Ramos, Rita M. La Rovere, Tomas Luyten, Marjorie Vermeersch, Patricia Tebabi, Marc Dieu, Bart Cuypers, Stijn Deborggraeve, Marion Rabant, Christophe Legendre, Søren K. Moestrup, Elena Levtchenko, Geert Bultynck, Christophe Erneux, David Pérez-Morga, Etienne Pays
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3821-3836.e13 (2020)
Summary: The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins
Externí odkaz:
https://doaj.org/article/3266daf22f2c432796add4a1fbe1a576
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growt
Externí odkaz:
https://doaj.org/article/9ccb1178e6e74b48a7a7e05f9c0d3d11
Autor:
Bart Cuypers, Laurence Lecordier, Conor J. Meehan, Frederik Van den Broeck, Hideo Imamura, Philippe Büscher, Jean-Claude Dujardin, Kris Laukens, Achim Schnaufer, Caroline Dewar, Michael Lewis, Oliver Balmer, Thomas Azurago, Sardick Kyei-Faried, Sally-Ann Ohene, Boateng Duah, Prince Homiah, Ebenezer Kofi Mensah, Francis Anleah, Jose Ramon Franco, Etienne Pays, Stijn Deborggraeve
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT African trypanosomes, except Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause human African trypanosomiasis, are lysed by the human serum protein apolipoprotein L1 (ApoL1). These two subspecies can resist human Ap
Externí odkaz:
https://doaj.org/article/16ed32b2f6534b7296f6ac0683f6f5da
Autor:
Sébastien Brosson, Frédéric Fontaine, Marjorie Vermeersch, David Perez-Morga, Etienne Pays, Sabrina Bousbata, Didier Salmon
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163302 (2016)
Trypanosoma cruzi is a protozoan parasite transmitted by a triatomine insect, and causing human Chagas disease in South America. This parasite undergoes a complex life cycle alternating between non-proliferative and dividing forms. Owing to their hig
Externí odkaz:
https://doaj.org/article/14f3ec48b45847299f31a1f981493185