Výsledky vyhledávání - "Etienne Pair"

Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels–Alder Pattern Common to Three Classes of Natural Products

Autor: Philippe Breton, Léon Ghosez, Solo Goldstein, Brigitte Lesur, Eduard Badarau, Jean Michel Henlin, K. Harsha Vardhan Reddy, Aurore Loudet, Etienne Pair, Jean Marie Fourquez, Stijn Claerhout, Stéphane Massip, Laurent Trembleau, Charles Simon

Publikováno v: Chemistry – A European Journal. 26:15477-15481

Identification of a common Diels-Alder pattern in three classes of bioactive natural products led us to study the synthesis and cycloaddition of a new class of cyclic dienes readily available from β,γ-unsaturated lactams. A practical and readily sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7208784b43ad0034592963c96644e70
https://doi.org/10.1002/chem.202002372

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Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors

Autor: Morgane Choquet, Elodie Lohou, Pascal Sonnet, Etienne Pair, Catherine Mullié

Publikováno v: Antimicrob Agents Chemother

Overexpression of efflux pumps extruding antibiotics currently used for the treatment of Acinetobacter baumannii infections has been described as an important mechanism causing antibiotic resistance. The first aim of this work was to phenotypically e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b252c0c2729f91b2ab482dd2432dafc
https://pubmed.ncbi.nlm.nih.gov/34097483

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Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives

Autor: Vincent Levacher, Julien Annibaletto, Jean-François Brière, Morgane Sanselme, Thomas Martzel, Etienne Pair, Sylvain Oudeyer, Pierre Millet

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26, pp.8541. ⟨10.1002/chem.202001214⟩

International audience; A straightforward multicomponent Knoevenagel‐aza‐Michael‐Cyclocondensation reaction involving readily available hydroxamic acid‐derived from naturally occurring α‐amino acids allows a diversity‐oriented synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c244a6ef7ad438a96499bc6240248df3
https://hal-normandie-univ.archives-ouvertes.fr/hal-02523950/document

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A Unique (3+2) Annulation Reaction between Meldrum's Acid and Nitrones: Mechanistic Insight by ESI-IMS-MS and DFT Studies

Autor: Carlos Afonso, Etienne Pair, Clisy Maganga, Marie Hubert-Roux, Corinne Loutelier-Bourhis, Vincent Tognetti, Nicolas Lespes, Marie Bretier, Laurent Joubert, Vincent Levacher, Jean-François Brière

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (16), pp.4086-4093. ⟨10.1002/chem.201705714⟩

International audience; The fragile intermediates of the domino process leading to an isoxazolidin‐5‐one, triggered by unique reactivity between Meldrum's acid and an N‐benzyl nitrone in the presence of a Brønsted base, were determined thanks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd8b136318fbfd45b897e4620b76428
https://doi.org/10.1002/chem.201705714

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Enantiopure substituted pyridines as promising antimalarial drug candidates

Autor: Etienne Pair, Alexandra Dassonville-Klimpt, Catherine Mullié, Guillaume Bentzinger, Jean Guillon, Mathieu Marchivie, Patrice Agnamey, Pascal Sonnet

Publikováno v: Tetrahedron
Tetrahedron, Elsevier, 2020, 76 (15), 131088 (10 p.). ⟨10.1016/j.tet.2020.131088⟩

International audience; We describe the enantioselective synthesis and biological evaluation of 4-(2-amino-1-hydroxyethyl)pyridines (4 AHPs) as new antimalarial drug candidates. In particular, two routes to obtain the key-intermediate 4-vinyl-pyridin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4f956114184e71e3fc9ec76081a1eb
https://doi.org/10.1016/j.tet.2020.131088

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Modified multicomponent Biginelli–Atwal reaction towards a straightforward construction of 5,6-dihydropyrimidin-4-ones

Autor: Jean-François Brière, Etienne Pair, Vincent Levacher

Publikováno v: RSC Advances
RSC Advances, Royal Society of Chemistry, 2015, 5 (57), pp.46267-46271. ⟨10.1039/c5ra08792a⟩

International audience; A straightforward access to 5,6-dihydropyrimidin-4-ones as racemic mixtures or enantiopure diastereoisomers was achieved thanks to a multicomponent Knoevenagel-aza-Michael-Cyclocondensation reaction involving Meldrum's acid an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688cb729d40006b50d9342fc931cf87a
https://doi.org/10.1039/c5ra08792a

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Copper-Catalyzed Trifluoromethylation ofN,N-Dialkylhydrazones

Autor: Olivier Baudoin, Etienne Pair, Nuno Monteiro, Didier Bouyssi

Publikováno v: Angewandte Chemie
Angewandte Chemie, Wiley-VCH Verlag, 2013, 52 (20), pp.5346-5349. ⟨10.1002/anie.201300782⟩

International audience; Mild and practical: Trifluoromethylation of (hetero)aromatic aldehyde N,N-dialkylhydrazones was achieved at room temperature by using Togni's trifluoromethylation reagent under CuCl catalysis (see scheme). This simple reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fdd014ec2c0789b5b2779f7a93bfc8
https://doi.org/10.1002/ange.201300782

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ChemInform Abstract: Meldrum′s Acid: A Useful Platform in Asymmetric Organocatalysis

Autor: Timothée Cadart, Etienne Pair, Jean-François Brière, Vincent Levacher

Publikováno v: ChemInform. 47

For more than a hundred years, Meldrum's acid and its derivatives have proven their utility and versatility in organic synthesis. Showing very unusual properties and multiple facets of reactivity, this small architecture has become the keystone of nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d5a85653c2d65990bab40cc4ea79b0b
https://doi.org/10.1002/chin.201631277

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Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis

Autor: Etienne Pair, Vincent Levacher, Timothée Cadart, Jean-François Brière

Publikováno v: ChemCatChem
ChemCatChem, Wiley, 2016, 8 (11), pp.1882-1890. ⟨10.1002/cctc.201600247⟩

International audience; For more than a hundred years, Meldrum's acid and its derivatives have proven their utility and versatility in organic synthesis. Showing very unusual properties and multiple facets of reactivity, this small architecture has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de48a511ba4dbd2e2c71821b2d4550f5
https://hal-normandie-univ.archives-ouvertes.fr/hal-02046231

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ChemInform Abstract: Modified Multicomponent Biginelli-Atwal Reaction Towards a Straightforward Construction of 5,6-Dihydropyrimidin-4-ones

Autor: Etienne Pair, Jean-François Brière, Vincent Levacher

Publikováno v: ChemInform. 46

The title dihydropyrimidinones are synthesized as racemic mixtures or enantiopure diastereomers (IX) by multicomponent Knoevenagel-aza-Michael-cyclocondensation reaction of Meldrum′s acid, isourea derivatives, and various aldehydes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a57ad4647415e2f44a41e2210c48138
https://doi.org/10.1002/chin.201538175

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