Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Etienne P. A. Neve"'
Autor:
Etienne P A Neve, Harald Köfeler, Delilah F G Hendriks, Åsa Nordling, Vladimir Gogvadze, Souren Mkrtchian, Erik Näslund, Magnus Ingelman-Sundberg
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138487 (2015)
Recently two novel enzymes were identified in the outer mitochondrial membrane, mARC1 and mARC2. These molybdenum containing enzymes can reduce a variety of N-hydroxylated compounds, such as N-hydroxy-guanidines and sulfohydroxamic acids, as well as
Externí odkaz:
https://doaj.org/article/ac02ed25d541439ebe9d04bfe6ab28ba
Publikováno v:
Molecular Pharmaceutics. 10:3152-3163
The absorption, distribution, metabolism, and excretion (ADME) of drugs in vivo are to a large extent dependent on different transport and metabolism routes. Elucidation of this complex transport-metabolism interplay is a major challenge in drug deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3182946481881597153305f2c21d92bd
https://doi.org/10.1021/mp400202d
https://doi.org/10.1021/mp400202d
Autor:
Louise Sivertsson, Etienne P. A. Neve, Margareta Porsmyr Palmertz, Magnus Ingelman-Sundberg, Irene Edebert
Publikováno v:
Molecular Pharmacology. 83:659-670
We have previously shown that confluent growth of the human hepatoma cell line Huh7 substantially induces the CYP3A4 mRNA, protein, and activity levels. Here, the mechanisms behind were investigated, and a transcriptome analysis revealed significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a973116f6e7599fb27f9c3a0690a73
https://doi.org/10.1124/mol.112.082305
https://doi.org/10.1124/mol.112.082305
Autor:
Åsa Nordling, Ulf Diczfalusy, Inger Johansson, Magnus Ingelman-Sundberg, Etienne P. A. Neve, Ulf Hellman, Tommy B. Andersson
Publikováno v:
Journal of Biological Chemistry. 287:6307-6317
Reduction of hydroxylamines and amidoximes is important for drug activation and detoxification of aromatic and heterocyclic amines. Such a reductase system was previously found to be of high activity in adipose tissue and liver, and furthermore, in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f93871f72010c2ee7eec06da75ea7d
https://doi.org/10.1074/jbc.m111.328237
https://doi.org/10.1074/jbc.m111.328237
Autor:
Malin Darnell, Magnus Ingelman-Sundberg, Monica Ek, Etienne P. A. Neve, Irene Edebert, Louise Sivertsson
Publikováno v:
Drug Metabolism and Disposition. 38:995-1002
Drug-induced hepatotoxicity is an important cause for disapproval, limitations of use, or withdrawal of drugs, and there is a high need for reproducible in vitro systems that can predict such toxicity. In this study, we show that confluent growth of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7812a81c0f167fdcefdfadf0ffac5232
https://doi.org/10.1124/dmd.110.032367
https://doi.org/10.1124/dmd.110.032367
Autor:
Joan Albanell, Jill R. Johnson, Ronald G. Crystal, Alexander Kukalev, Philip L. Leopold, Jonas Fuxe, Kristian Pietras, Antonio García de Herreros, Ismo Virtanen, Theresa Vincent, Etienne P. A. Neve, Lennart Philipson, Ralf F. Pettersson, Aristidis Moustakas, Federico Rojo
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
instname
Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, such as Ras and Wnt, to induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf60830c7ea4ac7ad46713fa8168e10e
https://doi.org/10.1038/ncb1905
https://doi.org/10.1038/ncb1905
Publikováno v:
Analytical and Bioanalytical Chemistry. 392:1075-1084
The cytochrome P450 (P450) enzymes are mainly localized to the endoplasmic reticulum (ER), where they function within catalytic complexes metabolizing xenobiotics and some endogenous substrates. However, certain members of families 1-3 were also foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f19f80c3153f0d385becbb47cf348f
https://doi.org/10.1007/s00216-008-2200-z
https://doi.org/10.1007/s00216-008-2200-z
Publikováno v:
Journal of Virology
Functional motifs within the cytoplasmic tails of the two glycoproteins G N and G C of Uukuniemi virus (UUK) ( Bunyaviridae family) were identified with the help of our recently developed virus-like particle (VLP) system for UUK virus (A. K. Overby,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d95a1a13efe8a40eea14d065d679541
Publikováno v:
Journal of Virology
We have analyzed the importance of specific amino acids in the cytoplasmic tail of the glycoprotein G N for packaging of ribonucleoproteins (RNPs) into virus-like particles (VLPs) of Uukuniemi virus (UUK virus), a member of the Bunyaviridae family. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefd707428fbc9a1c861414955eccc94
Autor:
Vladimir Gogvadze, Harald Köfeler, Erik Näslund, Souren Mkrtchian, Etienne P. A. Neve, Magnus Ingelman-Sundberg, Delilah F. G. Hendriks, Åsa Nordling
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138487 (2015)
PLoS ONE
PLoS ONE
Recently two novel enzymes were identified in the outer mitochondrial membrane, mARC1 and mARC2. These molybdenum containing enzymes can reduce a variety of N-hydroxylated compounds, such as N-hydroxy-guanidines and sulfohydroxamic acids, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1139b7737472098c7c88c9e0288fbef1
http://europepmc.org/articles/PMC4574727?pdf=render
http://europepmc.org/articles/PMC4574727?pdf=render