Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery

Autor: Etienne J. Slapak, Danny A. Zwijnenburg, Jan Koster, Maarten F. Bijlsma, C. Arnold Spek

Publikováno v: Oncogenesis, Vol 13, Iss 1, Pp 1-14 (2024)

Abstract Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges due to the inadequacy of existing chemotherapeutics, which often result in toxicity-dependent dose limitations and premature cessation of therapy. Targeted delivery of t

Externí odkaz: https://doaj.org/article/21affa4ad5fa4ab093c47cbbe4cb4702

Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?

Autor: Etienne J. Slapak, JanWillem Duitman, Cansu Tekin, Maarten F. Bijlsma, C. Arnold Spek

Publikováno v: Biology, Vol 9, Iss 4, p 80 (2020)

Pancreatic cancer is a dismal disorder that is histologically characterized by a dense fibrotic stroma around the tumor cells. As the extracellular matrix comprises the bulk of the stroma, matrix degrading proteases may play an important role in panc

Externí odkaz: https://doaj.org/article/854e41da336842e683ff4162e4fd55ac

ADAM9-responsive mesoporous silica nanoparticles for targeted drug delivery in pancreatic cancer

Autor: Etienne J Slapak, Mouad El Mandili, Alexander Kros, C. Arnold Spek, Rienk Nieuwland, Maarten F. Bijlsma, Lily Kong

Publikováno v: Cancers
Cancers, 13(13):3321. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 13(13). MDPI AG
Cancers, Vol 13, Iss 3321, p 3321 (2021)
Volume 13
Issue 13

Simple Summary The clinical efficacy of systemic chemotherapy is limited in pancreatic cancer (PDAC) due to toxicity-dependent dose-limitations often leading to premature cessation of therapy. Targeted delivery of chemotherapeutic drugs to cancer cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f071c20ef7ad55e25b7680840e4927d7
https://hdl.handle.net/1887/3210607