Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Etienne J. Donckele"'
Publikováno v:
ACS Pharmacology and Translational Science, 4 (4)
ACS Pharmacol Transl Sci
ACS Pharmacol Transl Sci
[Image: see text] DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology platform for the discovery of small-molecule ligands to protein targets of biological and pharmaceutical interest. DELs are collections of molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18be24eed5770192618615089594500
https://hdl.handle.net/20.500.11850/502751
https://hdl.handle.net/20.500.11850/502751
Autor:
Jörg Scheuermann, Luca Prati, Adrián Gironda-Martínez, Émile M. D. Gorre, Etienne J. Donckele, Jacopo Piazzi, Alessandro Sannino, Dario Neri, Florent Samain
Publikováno v:
ACS Combinatorial Science, 22 (4)
The growing importance of DNA-encoded chemical libraries (DECLs) as tools for the discovery of protein binders has sparked an interest for the development of efficient screening methodologies, capable of discriminating between high- and medium-affini
Publikováno v:
Biochemical and Biophysical Research Communications, 533 (2)
DNA-encoded chemical libraries (DECLs) are large compound collections attached to DNA fragments, serving as amplifiable barcodes, which can be screened on target proteins of pharmaceutical interest. In DECL selections, ligands are identified by high-
Publikováno v:
Organic Letters, 21 (23)
Organic Letters
Organic Letters
DNA-encoded chemical libraries (DECLs) are increasingly employed in hit discovery toward proteins of pharmaceutical interest. Protected amino acids are the most commonly used building blocks for the construction of DECLs; therefore, the expansion of
Publikováno v:
Angewandte Chemie. 129:12798-12801
Enantioselective Pd-catalyzed allylic alkylations of dihydropyrido[1,2-a]indolone (DHPI) substrates were used to construct the C20-quaternary stereocenters of multiple monoterpene indole alkaloids. Stereodivergent Pictet-Spengler and Bischler-Napiera
Autor:
Florent Samain, Jacopo Piazzi, Elena Gabriele, Jörg Scheuermann, Etienne J. Donckele, Martina Bigatti, Dario Neri, Sara Mulatto, Alessandro Sannino
Publikováno v:
ChemBioChem
ChemBioChem, 20 (7)
ChemBioChem, 20 (7)
DNA-encoded chemical libraries are often used for the discovery of ligands against protein targets of interest. These large collections of DNA-barcoded chemical compounds are typically screened by using affinity capture methodologies followed by PCR
Publikováno v:
European Journal of Organic Chemistry. 2016:716-724
The reactions of diethyl 2-(dicyanomethylene)malonate, an electron-deficient alkene, with donor-activated and unactivated alkynes have been investigated. Moderately electron-rich and unactivated alkynes undergo efficient formal [3+2] cycloaddition–
Autor:
Etienne J. Donckele, Corinne Boudon, Laurent Ruhlmann, François Diederich, Tristan A. Reekie, Nils Trapp
Publikováno v:
European Journal of Organic Chemistry. 2015:7264-7275
We report the reactions of electron-deficient alkenes, tetrasubstituted by carboxylic ester and cyano groups, with electron-rich (dimethylamino)phenyl-substituted alkynes. Mono- or diester-substituted alkenes exclusively undergo the [2+2] cycloadditi
Autor:
François Diederich, Corinne Boudon, Etienne J. Donckele, Aaron D. Finke, Nils Trapp, Laurent Ruhlmann
Publikováno v:
Organic Letters. 17:3506-3509
The reaction of electrophilic 2-(dicyanomethylene)indan-1,3-dione (DCID) with substituted, electron-rich alkynes provides two classes of push-pull chromophores with interesting optoelectronic properties. The formal [2 + 2] cycloaddition-retroelectroc
Publikováno v:
Journal of the American Chemical Society. 137:2776-2784
We report the discovery, synthesis, and application of a new class of non-C2-symmetric phosphoramidite ligands derived from pyroglutamic acid for use in both oxidative and redox-neutral palladium-catalyzed asymmetric allylic alkylations of 1,3-diketo