Výsledky vyhledávání - "Etienne Hanon"

Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model

Autor: Bénédicte Danis, Gregory Szczesny, Silvia Balosso, Catherine Vandenplas, Annamaria Vezzani, Kasper Claes, Jonathan van Eyll, Seon-Ah Chong, Christian Wolff, Xavier Van Damme, Etienne Hanon, Isabelle Niespodziany, Rafal Kaminski

Publikováno v: Neurotherapeutics

Understanding the mechanisms of epileptogenesis is essential to develop novel drugs that could prevent or modify the disease. Neuroinflammation has been proposed as a promising target for therapeutic interventions to inhibit the epileptogenic process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c459f466917cc5ddefed0c956b614f6e
https://doi.org/10.1007/s13311-018-0607-6

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Using Bayesian analysis in repeated preclinicalin vivostudies for a more effective use of animals

Autor: Etienne Hanon, Gillian Watt, Rosalind Walley, John Sherington, Joe Rastrick, Eric Detrait

Publikováno v: Pharmaceutical Statistics. 15:277-285

Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the preclinical area Bayesian methods appear to be rarely used in the reporting of pharmacology data. This is particularly surprising in the context of regularly repe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a433e162e0c3c2ba9a1e87226094302b
https://doi.org/10.1002/pst.1748

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Assessment of a Urinary Kidney MicroRNA Panel as Potential Nephron Segment-Specific Biomarkers of Subacute Renal Toxicity in Preclinical Rat Models

Autor: Sarah Dremier, Etienne Hanon, Sara Snelling, Andre Nogueira da Costa, Stephanie Glineur, Caroline Berteau, Pierrette De Ron

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 166(2)

Drug-induced kidney injury (DIKI) remains a significant concern during drug development. Whereas FDA-endorsed urinary protein biomarkers encounter limitations including the lack of translatability, there is a considerable interest surrounding the app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a84814ec64aaf57f0ecf5874d3ca333
https://pubmed.ncbi.nlm.nih.gov/30169741

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In vitro screening of cell bioenergetics to assess mitochondrial dysfunction in drug development

Autor: F.A. Atienzar, K. Tilmant, P. De Ron, Helga Gerets, Etienne Hanon, C. Bento-Pereira

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 52

Drug-induced mitochondrial toxicity is considered as a common cellular mechanism that can induce a variety of organ toxicities. In the present manuscript, 17 in vitro mitochondrial toxic drugs, reported to induce Drug-Induced Liver Injury (DILI) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820fcb4b2d6eb36c61153f9eed57a458
https://pubmed.ncbi.nlm.nih.gov/30030051

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Paving the Route to Plasma miR-208a-3p as an Acute Cardiac Injury Biomarker: Preclinical Rat Data Supports Its Use in Drug Safety Assessment

Autor: Stephanie Glineur, Andre Nogueira da Costa, Etienne Hanon, Pierrette De Ron, Jean-Pierre Valentin, Sarah Dremier

Publikováno v: Toxicological Sciences. 149:89-97

Drug-induced cardiac injury (DICI) detection remains a major safety issue in drug development. While circulating microRNAs (miRs) have emerged as promising translational biomarkers, novel early detection biomarkers of cardiotoxicity are needed. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebc6281b23f277206171b05682cc41d
https://doi.org/10.1093/toxsci/kfv222

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Brivaracetam Differentially Affects Voltage‐Gated Sodium Currents Without Impairing Sustained Repetitive Firing in Neurons

Autor: Philippe Ghisdal, Nathalie Leclère, Etienne Hanon, Christian Wolff, Isabelle Niespodziany, Véronique M. André

Publikováno v: CNS Neuroscience & Therapeutics

Summary Aims Brivaracetam (BRV) is an antiepileptic drug in Phase III clinical development. BRV binds to synaptic vesicle 2A (SV2A) protein and is also suggested to inhibit voltage-gated sodium channels (VGSCs). To evaluate whether the effect of BRV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a4bdaac2648fb01cb6e7609e264796
https://doi.org/10.1111/cns.12347

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Pramipexole induced place preference after L-dopa therapy and nigral dopaminergic loss: linking behavior to transcriptional modifications

Autor: Aziz Hafidi, Poppy L Winlow, Simon Loiodice, Sarah Dremier, David Dardou, Franck Durif, Omar Ouachikh, Etienne Hanon, Andre Nogueira da Costa

Publikováno v: Psychopharmacology
Psychopharmacology, Springer Verlag, 2017, 234 (1), pp.15-27. ⟨10.1007/s00213-016-4430-7⟩
Psychopharmacology, 2017, 234 (1), pp.15-27. ⟨10.1007/s00213-016-4430-7⟩
Psychopharmacology, Springer Verlag, 2017, 234 (1), pp.15-27. 〈10.1007/s00213-016-4430-7〉

Impulsive-compulsive disorders (ICD) in patients with Parkinson’s disease (PD) have been described as behavioral or substance addictions including hypersexuality, gambling, or compulsive medication use of the dopamine replacement therapy (DRT). A r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a172aa45fd8ab54e2d6da241e0badfdf
https://hal.uca.fr/hal-01688687

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Lack of synaptic vesicle protein SV2B protects against amyloid-β25–35-induced oxidative stress, cholinergic deficit and cognitive impairment in mice

Autor: Tangui Maurice, Karine Leclercq, Yves Lamberty, Etienne Hanon, Eric Detrait

Publikováno v: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2014, 271, pp.277-285. ⟨10.1016/j.bbr.2014.06.013⟩

International audience; SV2B is a synaptic protein widely distributed throughout the brain, which is part of the complex vesicle protein machinery involved in the regulation of synaptic vesicle endocytosis and exocytosis, and therefore in neurotransm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f896a46cba45653f5070e6e2d8c3e8
https://doi.org/10.1016/j.bbr.2014.06.013

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Different MicroRNA Profiles in Chronic Epilepsy Versus Acute Seizure Mouse Models

Autor: Franziska Siegel, Rafal M. Kaminski, Lidija Andonovic, Patrik Foerch, Holger Fröhlich, Etienne Hanon, Bénédicte Danis, Patrice Godard, Khalid Abnaof, Alexander Pfeifer, Anita Kretschmann, Marijke van Rikxoort, Manuela Mazzuferi

Publikováno v: Journal of Molecular Neuroscience

Epilepsy affects around 50 million people worldwide, and in about 65 % of patients, the etiology of disease is unknown. MicroRNAs are small non-coding RNAs that have been suggested to play a role in the pathophysiology of epilepsy. Here, we compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2048f89e09db7b6e4cb2e9f5e4110d17
https://doi.org/10.1007/s12031-014-0368-6

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Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis – Influence on microglial function

Autor: Jiong Zhang, Pitt Niehusmann, Daniel Delev, Marijke van Rikxoort, Marec von Lehe, Patrik Foerch, Lidija Andonovic, Etienne Hanon, Franziska Siegel, Rafal M. Kaminski, Bénédicte Danis, Patrice Godard, Alexander Pfeifer, Anita Kretschmann

Publikováno v: Scientific Reports

Epilepsy is one of the most common neurological disorders characterized by recurrent seizures due to neuronal hyperexcitability. Here we compared miRNA expression patterns in mesial temporal lobe epilepsy with and without hippocampal sclerosis (mTLE

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