Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Etienne C Gozlan"'
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Akademický článek
Chemical complementarity between immune receptors and cancer mutants, independent of antigen presentation protein binding, is associated with increased survival rates
Autor: Monica Hsiang, Boris I. Chobrutskiy, Michael Diaz, Taha I. Huda, Stefan Creadore, Saif Zaman, Konrad J. Cios, Etienne C. Gozlan, George Blanck
Publikováno v: Translational Oncology, Vol 14, Iss 6, Pp 101069- (2021)
Uterine cancer has been associated with a T-cell immune response that leads to increased survival. Therefore, we used several bioinformatics approaches to explore specific interactions between T-cell receptor (TCR) and tumor mutant peptide sequences.
Externí odkaz: https://doaj.org/article/e1ec094967794abdb41c19add700e36b
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4
Immunogenomics Parameters for Patient Stratification in Alzheimer’s Disease
Autor: Taha I. Huda, Michael J. Diaz, Etienne C. Gozlan, Andrea Chobrutskiy, Boris I. Chobrutskiy, George Blanck
Publikováno v: Journal of Alzheimer's Disease. 88:619-629
Background: Despite the fact that only modest adaptive immune system related approaches to treating Alzheimer’s disease (AD) are available, an immunogenomics approach to the study of AD has not yet substantially advanced. Objective: Thus, we sought
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e82311e2c5d3cbfa7168b09f673f87
https://doi.org/10.3233/jad-220119
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5
The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with tumor resident, adaptive immune receptor features
Autor: Jacob C Kinskey, Taha I Huda, Etienne C Gozlan, Jessica U Quach, Juan F Arturo, Andrea Chobrutskiy, Boris I Chobrutskiy, George Blanck
Publikováno v: Carcinogenesis.
The association between pancreatic adenocarcinoma (PAAD) and the pancreatic microbiome is not fully understood, although bacteria may decrease the effectiveness of chemotherapy and lead to anti-apoptotic, pro-inflammatory-microenvironments. To better
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ca94123694983d643ad21ef2ae2458e
https://doi.org/10.1093/carcin/bgad033
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6
A Bioinformatics Assessment Indicating Better Outcomes With Breast Cancer Resident, Immunoglobulin CDR3-MMP2 Binding
Autor: SUHAAS R. MANDALA, ALEXIS J. THOMSON, ETIENNE C. GOZLAN, DHRUV N. PATEL, ANDREA CHOBRUTSKIY, BORIS I. CHOBRUTSKIY, GEORGE BLANCK
Publikováno v: Cancer Genomics Proteomics
Background/Aim: The recombination of V, D, and J immunoglobulin (IG) gene segments leads to many variations in the amino acids (AAs) encoded at that site, the complementarity determining region-3 (CDR3). Thus, cancer patients may have varying degrees
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d975c140720acc26d2bbcb3a770935
https://europepmc.org/articles/PMC10148069/
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7
Exploiting adaptive immune receptor recombination read recoveries from exome files to identify subsets of ALL and to establish TCR features that correlate with better outcomes
Autor: Etienne C. Gozlan, Boris I. Chobrutskiy, George Blanck
Publikováno v: International Journal of Laboratory Hematology. 44:883-891
The recovery of adaptive immune receptor (IR) recombination reads from tumour-derived genomics files has advanced the understanding of the immune system's interaction with cancer. This approach has been largely limited to solid tumours, where genomic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde7ba895cf87852f62f22e29a5c6702
https://doi.org/10.1111/ijlh.13862
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9
Systemic Adaptive Immune Parameters Associated with Neuroblastoma Outcomes: the Significance of Gamma-Delta T Cells
Autor: Etienne C. Gozlan, George Blanck, Saif Zaman, Michelle Yeagley, Boris I. Chobrutskiy
Publikováno v: Journal of Molecular Neuroscience. 71:2393-2404
We mined a set of neuroblastoma (NBL) exomes for immune receptor recombinations representing all seven, human adaptive immune receptor genes, using a very high standard for identifications of V- and J-gene segments in sequencing reads. Results indica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0802f7a29a85d051e81cfea3b8306fc1
https://doi.org/10.1007/s12031-021-01813-x
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10
Specific HLA alleles, paired with TCR V- and J-gene segment usage, link to distinct multiple myeloma survival rates
Autor: Mary F. Arndt, Etienne C. Gozlan, Michael J. Diaz, Saif Zaman, Moody M. Mihyu, George Blanck, Boris I. Chobrutskiy, Taha I. Huda
Publikováno v: Leukemia & Lymphoma. 62:1711-1720
Multiple myeloma (MM) immunogenomics studies related to T-cell characterizations and involving large patient sets have been lacking, particularly in comparison to solid tumor types. Thus, we evaluated (i) HLA alleles, and (ii) T-Cell Receptor (TCR) V
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623b3c7a875dd3b7e92a0f1868795b08
https://doi.org/10.1080/10428194.2021.1885655
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