PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions

Autor: Valentin Garcia, Marine Blaquiere, Alicia Janvier, Noemie Cresto, Carla Lana, Athenais Genin, Helene Hirbec, Etienne Audinat, Adele Faucherre, Emmanuel L. Barbier, Sophie Hamelin, Philippe Kahane, Chris Jopling, Nicola Marchi

Publikováno v: Neurobiology of Disease, Vol 187, Iss , Pp 106297- (2023)

Mechanosensors are emerging players responding to hemodynamic and physical inputs. Their significance in the central nervous system remains relatively uncharted. Using human-derived brain specimens or cells and a pre-clinical model of mesio-temporal

Externí odkaz: https://doaj.org/article/c1415310d3054dd4ace2dd6dec496b9a

Therapeutic Potential of Astrocyte Purinergic Signalling in Epilepsy and Multiple Sclerosis

Autor: Paola Nobili, Weida Shen, Katarina Milicevic, Jelena Bogdanovic Pristov, Etienne Audinat, Ljiljana Nikolic

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Epilepsy and multiple sclerosis (MS), two of the most common neurological diseases, are characterized by the establishment of inflammatory environment in the central nervous system that drives disease progression and impacts on neurodegeneration. Cur

Externí odkaz: https://doaj.org/article/c64cdc85900142f698d543c583e15464

Microglia states and nomenclature

Autor: Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C. Brown, Oleg Butovsky, Monica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimitrios Davalos, Philip L. De Jager, Bart de Strooper, Adam Denes, Bart J.L. Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K. Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta González, Siamon Gordon, Manuel B. Graeber, Andrew D. Greenhalgh, Pierre Gressens, Melanie Greter, David H. Gutmann, Christian Haass, Michael T. Heneka, Frank L. Heppner, Soyon Hong, David A. Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W. McColl, Veronique E. Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J. Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V. Hugh Perry, Phillip G. Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M. Ransohoff, Michael W. Salter, Anne Schaefer, Dorothy P. Schafer, Michal Schwartz, Mikael Simons, Cody J. Smith, Wolfgang J. Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valérie Wittamer, Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray

Publikováno v: Neuron
Neuron, vol 110, iss 21
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M-E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, de Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L-H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L-J & Wyss-Coray, T 2022, ' Microglia states and nomenclature : A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron 110(21), 3458-3483 (2022). doi:10.1016/j.neuron.2022.10.020
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, De Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L J & Wyss-Coray, T 2022, ' Microglia states and nomenclature: A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron, 2022, 110 (21), pp.3458-3483. ⟨10.1016/j.neuron.2022.10.020⟩

International audience; Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603341ba45a426c6d4f33e2cb8a2abc6
http://www.scopus.com/inward/record.url?scp=85140895591&partnerID=8YFLogxK

Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

Autor: Lukas Henning, Henrike Antony, Annika Breuer, Julia Müller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhäuser, Peter Bedner

Publikováno v: Glia 71(2), 168-186 (2023). doi:10.1002/glia.24265

Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and progression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7febe93f8d8c48e53108d8572a2f2a1d

High-speed optical mapping of heart and brain voltage activities in zebrafish larvae exposed to environmental contaminants

Autor: Solene Micou, Isabel Forner-Piquer, Noemie Cresto, Tess Zassot, Aurélien Drouard, Marianne Larbi, Matteo E. Mangoni, Etienne Audinat, Chris Jopling, Adèle Faucherre, Nicola Marchi, Angelo G. Torrente

Publikováno v: Environmental Technology & Innovation. :103196

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13a2a423066e2812e07f1bba1d18eb7c
https://doi.org/10.1016/j.eti.2023.103196