Zobrazeno 1 - 10
of 1 031
pro vyhledávání: '"Etienne, Sibille"'
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 38, Iss , Pp 100761- (2024)
Inflammation, reduced gamma-aminobutyric acidergic (GABAergic) function and altered neuroplasticity are co-occurring pathophysiologies in major depressive disorder (MDD). However, the link between these biological changes remains unclear. We hypothes
Externí odkaz:
https://doaj.org/article/4837eb1df0ff49c2a3d44a7fcfecf24c
Autor:
Alexandre Guet-McCreight, Homeira Moradi Chameh, Frank Mazza, Thomas D. Prevot, Taufik A. Valiante, Etienne Sibille, Etay Hay
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Reduced inhibition by somatostatin-expressing interneurons is associated with depression. Administration of positive allosteric modulators of α5 subunit-containing GABAA receptor (α5-PAM) that selectively target this lost inhibition exhibi
Externí odkaz:
https://doaj.org/article/dc686f02d621430eacfbf2ab601663ad
Autor:
Ravinder Naik Dharavath, Celeste Pina-Leblanc, Victor M. Tang, Matthew E. Sloan, Yuliya S. Nikolova, Peter Pangarov, Anthony C. Ruocco, Kevin Shield, Daphne Voineskos, Daniel M. Blumberger, Isabelle Boileau, Nikki Bozinoff, Philip Gerretsen, Erica Vieira, Osnat C. Melamed, Etienne Sibille, Lena C. Quilty, Thomas D. Prevot
Publikováno v:
Frontiers in Neural Circuits, Vol 17 (2023)
Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (
Externí odkaz:
https://doaj.org/article/3d71423280734b9381c1657b86041ec5
Autor:
Stephanie M. Perez, Alexandra M. McCoy, Thomas D. Prevot, Md Yeunus Mian, Flavia R. Carreno, Alan Frazer, James M. Cook, Etienne Sibille, Daniel J. Lodge
Publikováno v:
Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 78-86 (2023)
Background: Aberrant dopamine neuron activity is attributable to hyperactivity in hippocampal subfields driving a pathological increase in dopamine neuron activity, which is positively correlated with psychosis in humans. Evidence indicates that hipp
Externí odkaz:
https://doaj.org/article/084ff4c6137d42009c20604b31e46173
Autor:
Kevan P. Clifford, Amy E. Miles, Thomas D. Prevot, Keith A. Misquitta, Jacob Ellegood, Jason P. Lerch, Etienne Sibille, Yuliya S. Nikolova, Mounira Banasr
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAs the population skews toward older age, elucidating mechanisms underlying human brain aging becomes imperative. Structural MRI has facilitated non-invasive investigation of lifespan brain morphology changes, yet this domain remains unch
Externí odkaz:
https://doaj.org/article/94abd58255c441f4af8b8292591b2ad4
Autor:
Ana Paula Mendes-Silva, Thomas Damien Prevot, Mounira Banasr, Etienne Sibille, Breno Satler Diniz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
BackgroundThe cell cycle is a critical mechanism for proper cellular growth, development and viability. The p16INK4a and p21Waf1/Cip1 are important regulators of the cell cycle progression in response to internal and external stimuli (e.g., stress).
Externí odkaz:
https://doaj.org/article/06ea96e31ba9434c902f032181992691
Autor:
Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D. Prevot, Etienne Sibille, Jeffrey M. Witkin, James M. Cook
Publikováno v:
Molecules, Vol 28, Iss 12, p 4771 (2023)
GABA mediates inhibitory actions through various GABAA receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizop
Externí odkaz:
https://doaj.org/article/acec2607b20b4845bf8d9d92e46a9997
Autor:
Victoria S. Marshe, Malgorzata Maciukiewicz, Anne-Christin Hauschild, Farhana Islam, Li Qin, Arun K. Tiwari, Etienne Sibille, Daniel M. Blumberger, Jordan F. Karp, Alastair J. Flint, Gustavo Turecki, Raymond W. Lam, Roumen V. Milev, Benicio N. Frey, Susan Rotzinger, Jane A. Foster, Sidney H. Kennedy, James L. Kennedy, Benoit H. Mulsant, Charles F. Reynolds, Eric J. Lenze, Daniel J. Müller
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepress
Externí odkaz:
https://doaj.org/article/efbdb20aed5640e18934bb4600d561d7
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and affects individuals of all ages. It causes significant psychosocial impairments and is a major cause of disability. A recent consortium study identified
Externí odkaz:
https://doaj.org/article/e4d1d64060664cfda83edb88a4cf5b69
Autor:
Klara Mareckova, Colin Hawco, Fernanda C. Dos Santos, Arin Bakht, Navona Calarco, Amy E. Miles, Aristotle N. Voineskos, Etienne Sibille, Ahmad R. Hariri, Yuliya S. Nikolova
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Convergent data from imaging and postmortem brain transcriptome studies implicate corticolimbic circuit (CLC) dysregulation in the pathophysiology of depression. To more directly bridge these lines of work, we generated a novel transcriptome
Externí odkaz:
https://doaj.org/article/dbafa41f027b40dd8f5ac8b8259d1435