A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine

Autor: Ethlinn V.B. van Gaal, Niels Hagenaars, Rolf J. Verheul, Wim E. Hennink, Thomas van Es, J.G.M. Heldens, Han van den Bosch, Bram Slütter, Pascal H.J.L.F. de Jong, Harrie L. Glansbeek, Enrico Mastrobattista, Ivo Que, Wim Jiskoot, Sven C. M. Bruijns

Publikováno v: Verheul, R J, Hagenaars, N, van Es, T, van Gaal, E V B, De Jong, P H J L, Bruijns, S C M, Mastrobattista, E, Slutter, B, Que, I, Heldens, J G M, van den Bosch, J F, Glansbeek, H L, Hennink, W E & Jiskoot, W 2012, ' A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine ', European Journal of Pharmaceutical Sciences, vol. 45, no. 4, pp. 467-474 . https://doi.org/10.1016/j.ejps.2011.10.001
European Journal of Pharmaceutical Sciences, 45(4), 467-474. Elsevier
European Journal of Pharmaceutical Sciences, 45(4), 467-474

Recently we reported that reacetylation of N,N,N-trimethyl chitosan (TMC) reduced the adjuvant effect of TMC in mice after intranasal (i.n.) administration of whole inactivated influenza virus (WIV) vaccine. The aim of the present study was to elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2805f81cd6a874130bfba468c4a6c5fa
https://doi.org/10.1016/j.ejps.2011.10.001

Polymeric Micelles

Autor: Ethlinn V.B. van Gaal, Daan J.A. Crommelin

Publikováno v: Non-Biological Complex Drugs ISBN: 9783319162409

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eebedc086fc60dd4daa8da5111d18d76
https://doi.org/10.1007/978-3-319-16241-6_2

Quick-and-easy preparation and purification of quantum dot-loaded liposomes

Autor: Clara van Emmerik, Morten B. Hansen, Ethlinn V.B. van Gaal, Dennis W. P. M. Löwik, Jan C. M. van Hest, Gert Storm

Publikováno v: Journal of nanoparticle research, 15(1):1340. Springer

Quantum dots are very attractive as fluorescent markers because of their excellent optical properties. For this reason, they have also been used to label liposomes by means of encapsulation, though their feasibility as liposome labels is often hamper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0c273621fe072b579665c085b71857
https://research.utwente.nl/en/publications/8e694efc-cae1-40f8-957d-49ae92bb90c3

Decationized crosslinked polyplexes for redox-triggered gene delivery

Autor: Cornelus F. van Nostrum, Luís Novo, Enrico Mastrobattista, Ethlinn V.B. van Gaal, Wim E. Hennink

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 169(3)

The clinical applicability of polymers as gene delivery systems depends not only on their efficiency, but also on their safety. The cytotoxicity of these systems remains a major issue, mainly due to their cationic nature. Therefore, it is highly pref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3889426bb1ffd156fc670f393e8ee517
https://pubmed.ncbi.nlm.nih.gov/23583705

DNA nuclear targeting sequences for non-viral gene delivery

Autor: Ronald S. Oosting, Robbert J. Kok, Roel van Eijk, Ethlinn V.B. van Gaal, Wim E. Hennink, Dries A. M. Feyen, Enrico Mastrobattista, Marta Bakowska, Daan J.A. Crommelin

Publikováno v: Pharmaceutical Research

Purpose To evaluate if introduction of DNA nuclear Targeting Sequences (DTS; i.e. recognition sequences for endogenous DNA-binding proteins) in plasmid DNA (pDNA) leads to increased transfection efficiency of non-viral gene delivery by virtue of enha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc97085da2d9eacdfbe6c272bff857fd
https://pubmed.ncbi.nlm.nih.gov/21424159