Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ethel C Derr-Yellin"'
Publikováno v:
Molecular Brain Research. 111:123-135
PCBs have been shown to alter several neurochemical end-points and are implicated in the etiology of some neurological diseases. Recent in vivo studies from our laboratory indicated that developmental exposure to a commercial PCB mixture, Aroclor 125
Autor:
Janet J. Diliberto, Linda S. Birnbaum, Narayanan Kannan, Prasada Rao S. Kodavanti, Deborah E. Burgin, Ethel C. Derr-Yellin
Publikováno v:
Environmental Health Perspectives
Aroclor 1254 is a commercial mixture of polychlorinated biphenyls (PCBs), which is defined as being 54% chlorine by weight. However, the congener composition varies from lot to lot. Two lots which have been used in toxicity studies, 124-191 and 6024
Autor:
Narayanan Kannan, Linda S. Birnbaum, Prasada Rao S. Kodavanti, Nobuyoshi Yamashita, Thomas R. Ward, Hugh A. Tilson, Ethel C. Derr-Yellin, Deborah E. Burgin
Publikováno v:
Environmental Health Perspectives
Aroclor 1254 is a widely studied commercial polychlorinated biphenyl (PCB) mixture which, by definition, contains 54% chlorine by weight. Recent reports indicate substantial differences in the congener composition among Aroclor lots and hence their b
Autor:
Hugh A. Tilson, Ethel C. Derr-Yellin, William R. Mundy, Robert C. MacPhail, Timothy J. Shafer, Stanley Barone, Prasada Rao S. Kodavanti, David W. Herr, Neepa Choksi
Publikováno v:
Toxicology and Applied Pharmacology. 153:186-198
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, some of which may be neurotoxic. In vitro studies from this laboratory indicated that noncoplanar PCBs perturbed intracellular signal transduction mechanisms including Ca2+ h
Autor:
Prasada Rao S. Kodavanti, Thomas R. Ward, Ethel C Derr-Yellin, Hugh A. Tilson, James D. McKinney
Publikováno v:
Neurotoxicology. 24(2)
Our previous structure–activity relationship (SAR) studies indicated that the effects of polychlorinated biphenyls (PCBs) on neuronal Ca2+ homeostasis and protein kinase C (PKC) translocation were associated with the extent of coplanarity. Chlorine
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 68(2)
Polybrominated diphenyl ethers (PBDEs), which are widely used as flame-retardants, have been increasing in environmental and human tissue samples during the past 20-30 years, while other structurally related, persistent organic pollutants such as pol
Autor:
Prasada Rao S. Kodavanti, Virginia C. Moser, Wendy M. Oshiro, Robert C. MacPhail, Pamela M. Phillips, Philip J. Bushnell, Ethel C. Derr-Yellin
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 68(1)
Because of behavioral deficits associated with gestational exposure to PCBs in children, we sought to quantify neurobehavioral effects of perinatal exposure to Aroclor 1254(R) (A1254), a commercial mixture of PCBs, in rats. Pregnant Long-Evans rats w
Autor:
Kevin M. Crofton, Ethel C Derr-Yellin, Prasada Rao S. Kodavanti, Jaimie E. Graff, David W. Herr
Publikováno v:
Neurotoxicology and teratology. 23(6)
Pregnant Long-Evans rats were exposed to 0, 1 or 6 mg/kg/day of Aroclor 1254 (A1254; Lot no. 124-191), a commercial mixture of polychlorinated biphenyls (PCBs), from gestation day (GD) 6 through postnatal day (PND) 21. At 128-140 days of age, male an
Publikováno v:
Toxicology. 156(1)
Earlier reports from our laboratory have indicated that polychlorinated biphenyls (PCBs) affect signal transduction mechanisms in brain, including Ca2+ homeostasis, phosphoinositol hydrolysis, and protein kinase C (PKC) translocation in mature neuron
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 57(1)
Previous research has demonstrated the sensitivity of the developing rat to the hypothyroxinemic and ototoxic effects of perinatal exposure to Aroclor 1254 (A1254). We tested the hypothesis that postnatal exposure via lactation is the major cause of