Using fluorescence polarization immunoassay for determination of erythrocyte methotrexate polyglutamates, a quick and easy test?

Autor: Birgit C. P. Koch, Robert de Jonge, Ethan den Boer, Ruud Huisman

Publikováno v: Therapeutic Drug Monitoring, 36(6), 819-823. Lippincott Williams and Wilkins
Therapeutic Drug Monitoring, 36(6), 819-823. Lippincott Williams & Wilkins
Den Boer, E, Koch, B C, Huisman, R & De Jonge, R 2014, ' Using fluorescence polarization immunoassay for determination of erythrocyte methotrexate polyglutamates, a quick and easy test? ', Therapeutic Drug Monitoring, vol. 36, no. 6, pp. 819-823 . https://doi.org/10.1097/FTD.0000000000000085

BACKGROUND:: The folate antagonist methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis. The therapeutic effects of MTX are attributed to the intracellular levels of MTX, present in the cell as polyglutamates (MTX-PGs). We a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622462a801736004b40de0badc5842b3
https://doi.org/10.1097/ftd.0000000000000085

Letter to the editor in response to the article 'Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients' by Kivity S, Zafrir Y, Loebstein R, Pauzner R, Mouallem M, Mayan H, Autoimmun Rev. 2014 Nov.;13(11):1109-13 Height of MTX-PG levels in low-dose MTX-toxicity differs according to the time of onset

Autor: Robert de Jonge, Johanna M. W. Hazes, Elsbeth M. Westerman, Sophie Wassenaar, Ethan den Boer

Publikováno v: Autoimmunity Reviews, 15(11), 1109-1110. Elsevier
Wassenaar, S, den Boer, E, Westerman, E M, Hazes, J M & de Jonge, R 2016, ' Letter to the editor in response to the article "Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients" by Kivity S, Zafrir Y, Loebstein R, Pauzner R, Mouallem M, Mayan H, Autoimmun Rev. 2014 Nov.;13(11):1109-13 Height of MTX-PG levels in low-dose MTX-toxicity differs according to the time of onset ', Autoimmunity Reviews, vol. 15, no. 11, pp. 1109-1110 . https://doi.org/10.1016/j.autrev.2016.04.006

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997d1aef2ac2b98ec6e38299d1f961b5
https://research.vumc.nl/en/publications/d5c9ec15-c215-47ad-8754-3a69ae6dbff6

Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry

Autor: Roland J. W. Meesters, Ethan den Boer, Robert de Jonge, Theo M. Luider, Jan Lindemans

Publikováno v: Rapid Communications in Mass Spectrometry. 25:3063-3070

A new ultrafast quantitative and high-throughput mass spectrometric method using matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry has been developed and validated for determination of intracellular erythrocyte co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf7cefd4551ec5efc45df71419926f09
https://doi.org/10.1002/rcm.5202

Determinants of Erythrocyte Methotrexate Polyglutamate Levels in Rheumatoid Arthritis

Autor: Maurits C J F de Rotte, Robert de Jonge, Saskia M F Pluijm, Ethan den Boer, Sandra G. Heil, Johanna M. W. Hazes

Publikováno v: Journal of Rheumatology, 41(11), 2167-2178. Journal of Rheumatology

Objective.Low-dose methotrexate (MTX) is the anchor drug in the treatment for rheumatoid arthritis (RA). Response to MTX is related to the intracellular MTX-polyglutamate (MTX-PG) levels and little is known about its determinants. We aimed to define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00795c38c7e724b7fc1538de63dbf9f
https://pure.eur.nl/en/publications/9341a49e-3988-4c97-8880-cc14e219b5fe

Effect of methotrexate use and erythrocyte methotrexate polyglutamate on glycosylated hemoglobin in rheumatoid arthritis

Autor: Maurits C F J, de Rotte, Pascal H P, de Jong, Ethan, den Boer, Saskia M F, Pluijm, Behiye, Özcan, Angelique E A M, Weel, Jan, Lindemans, Johanna M W, Hazes, Robert, de Jonge

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 66(8)

To investigate whether methotrexate (MTX) use, as compared to other therapies, and erythrocyte methotrexate polyglutamate (MTXGlu) concentrations are associated with changes in glycosylated hemoglobin (HbA1c ) levels in rheumatoid arthritis (RA) pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6dc52787673762a561b0ba99999a166
https://pubmed.ncbi.nlm.nih.gov/24692301