Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ethan Y. Xu"'
Autor:
Rachna Manek, Yao V. Zhang, Patricia Berthelette, Mahmud Hossain, Cathleen S. Cornell, Joseph Gans, Gulbenk Anarat-Cappillino, Sarah Geller, Robert Jackson, Dan Yu, Kuldeep Singh, Sue Ryan, Dinesh S. Bangari, Ethan Y. Xu, Sirkka R. M. Kyostio-Moore
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH) in liver resulting in blood phenylalanine (Phe) elevation and neurotoxicity. A pegylated phenylalanine ammonia lyase (PEG-PAL) metabolizing Phe into cinnamic ac
Externí odkaz:
https://doaj.org/article/f3a454c49a4a458db2c91e87d25ee520
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Dogs with X-linked hereditary nephropathy (XLHN) are an animal model for Alport syndrome in humans and progressive chronic kidney disease (CKD). Using mRNA sequencing (mRNA-seq), we have characterized the gene expression profile affecting th
Externí odkaz:
https://doaj.org/article/3328a2122ff94a219f309016a106ffb7
Autor:
Zhi-Xiang Xu, Gyu Hyun Kim, Ji-Wei Tan, Anna E. Riso, Ye Sun, Ethan Y. Xu, Guey-Ying Liao, Haifei Xu, Sang-Hoon Lee, Na-Young Do, Chan Hee Lee, Amy E. Clipperton-Allen, Soonwook Kwon, Damon T. Page, Kea Joo Lee, Baoji Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in m
Externí odkaz:
https://doaj.org/article/2eeb7a9bfcc54e13b36e4785832892af
Autor:
Diana Rubel, Joseph Boulanger, Florin Craciun, Ethan Y. Xu, Yanqin Zhang, Lucy Phillips, Michelle Callahan, William Weber, Wenping Song, Nicholas Ngai, Nikolay O. Bukanov, Xingyi Shi, Ali Hariri, Hervé Husson, Oxana Ibraghimov-Beskrovnaya, Shiguang Liu, Oliver Gross
Publikováno v:
Cells, Vol 11, Iss 4, p 594 (2022)
Col4a3−/− Alport mice serve as an animal model for renal fibrosis. MicroRNA-21 (miR-21) expression has been shown to be increased in the kidneys of Alport syndrome patients. Here, we investigated the nephroprotective effects of Lademirsen anti-mi
Externí odkaz:
https://doaj.org/article/c718a14f7c9d4c8e9cc449aec48ae2ec
Autor:
Diana Rubel, Joseph Boulanger, Florin Craciun, Ethan Y. Xu, Yanqin Zhang, Lucy Phillips, Michelle Callahan, William Weber, Wenping Song, Nicholas Ngai, Nikolay O. Bukanov, Xingyi Shi, Ali Hariri, Hervé Husson, Oxana Ibraghimov-Beskrovnaya, Shiguang Liu, Oliver Gross
Publikováno v:
Cells; Volume 11; Issue 4; Pages: 594
Col4a3−/− Alport mice serve as an animal model for renal fibrosis. MicroRNA-21 (miR-21) expression has been shown to be increased in the kidneys of Alport syndrome patients. Here, we investigated the nephroprotective effects of Lademirsen anti-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631713f9703d6fac1ed802d2fcb53a83
https://pubmed.ncbi.nlm.nih.gov/35203245
https://pubmed.ncbi.nlm.nih.gov/35203245
Autor:
Kuldeep Singh, Mahmud Hossain, Rachna Manek, Patricia Berthelette, Cathleen S. Cornell, Robert B. Jackson, Dan Yu, Gulbenk Anarat-Cappillino, Ethan Y Xu, Dinesh S. Bangari, Joseph Gans, Yao V. Zhang, Sarah Geller, Sue Ryan, Sirkka Kyostio-Moore
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH) in liver resulting in blood phenylalanine (Phe) elevation and neurotoxicity. A pegylated phenylalanine ammonia lyase (PEG-PAL) metabolizing Phe into cinnamic acid was re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8f4236f0cea04e559ee9f7ab11f1cc
http://europepmc.org/articles/PMC8613214
http://europepmc.org/articles/PMC8613214
Autor:
Lucy Phillips, Shiguang Liu, Fang Wang, Li Yang, Oxana Ibraghimov-Beskrovnaya, Deidre Mackenna, Jifan Guo, Suxia Wang, Wenping Song, Jie Ding, Ekkehard Leberer, Cynthia Pryce, Ethan Y Xu, Qun He, Yanqin Zhang, Joseph Boulanger
Publikováno v:
Human Gene Therapy. 30:865-881
Alport syndrome is a genetic disease caused by mutations in type IV collagen and is characterized by progressive kidney disease. The Col4α3−/− mouse model recapitulates the main features of human A...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4342d753eae274c01e0d81daecd0f7b8
https://doi.org/10.1089/hum.2018.205
https://doi.org/10.1089/hum.2018.205
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Dogs with X-linked hereditary nephropathy (XLHN) are an animal model for Alport syndrome in humans and progressive chronic kidney disease (CKD). Using mRNA sequencing (mRNA-seq), we have characterized the gene expression profile affecting the progres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22076d93c44d5c2e9a62eba6b36c68f5
https://pubmed.ncbi.nlm.nih.gov/34465843
https://pubmed.ncbi.nlm.nih.gov/34465843
Autor:
Soonwook Kwon, Kea Joo Lee, Sang-Hoon Lee, Amy E. Clipperton-Allen, Ji Wei Tan, Guey Ying Liao, Zhi-Xiang Xu, Chan Hee Lee, Damon T. Page, Baoji Xu, Na Young Do, Haifei Xu, Gyu Hyun Kim, Anna Riso, Ethan Y. Xu, Ye Sun
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction and communication deficits and repetitive behaviors. However, the cells that cause ASD th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e77987005e939257d5d7891cd4ce1db
http://europepmc.org/articles/PMC7156673
http://europepmc.org/articles/PMC7156673
Autor:
Jun Zhu, Pavel Sova, Qiuwei Xu, Kenneth M Dombek, Ethan Y Xu, Heather Vu, Zhidong Tu, Rachel B Brem, Roger E Bumgarner, Eric E Schadt
Publikováno v:
PLoS Biology, Vol 10, Iss 4, p e1001301 (2012)
Cells employ multiple levels of regulation, including transcriptional and translational regulation, that drive core biological processes and enable cells to respond to genetic and environmental changes. Small-molecule metabolites are one category of
Externí odkaz:
https://doaj.org/article/f8b17d78167047718c85710e12345a43