Výsledky vyhledávání - "Ethan Wickline"

Akademický článek

The molecular basis for recognition of 5′-NNNCC-3′ PAM and its methylation state by Acidothermus cellulolyticus Cas9

Autor: Anuska Das, Travis H. Hand, Chardasia L. Smith, Ethan Wickline, Michael Zawrotny, Hong Li

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Acidothermus cellulolyticus CRISPR-Cas9 (AceCas9) is a Type II-C enzyme that cleaves DNA in a Protospacer Adjacent Motif (PAM) methylation sensitive fashion. Biochemical analysis and crystal structures of AceCas9 in complex with sgRNA and DNA bearing

Externí odkaz: https://doaj.org/article/2cea4907f71b47c69f5853d72886df10

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The molecular basis for recognition of 5′-NNNCC-3′ PAM and its methylation state by Acidothermus cellulolyticus Cas9

Autor: Travis H. Hand, Hong Li, Ethan Wickline, Michael Zawrotny, Anuska Das, Chardasia L. Smith

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications

Acidothermus cellulolyticus CRISPR-Cas9 (AceCas9) is a thermophilic Type II-C enzyme that has potential genome editing applications in extreme environments. It cleaves DNA with a 5′-NNNCC-3′ Protospacer Adjacent Motif (PAM) and is sensitive to it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801036f79397f8fb4de92bcd1b3d41fb
https://doi.org/10.1038/s41467-020-20204-1

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