Výsledky vyhledávání - "Ethan S. Winter"

In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Development of a Fluorogenic Activity Probe

Autor: Ethan S. Winter, Emily P. Balskus, Matthew R. Volpe, Matthew R. Wilson, Carolyn A. Brotherton, Sheila E. Johnson

Publikováno v: ACS Chem Biol

The gut bacterial genotoxin colibactin has been linked to the development of colorectal cancer. In the final stages of colibactin’s biosynthesis, an inactive precursor (pre-colibactin) undergoes proteolytic cleavage by ClbP, an unusual inner-membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23494fe88700cbefc5cd14bee65d4548
https://doi.org/10.1021/acschembio.9b00069

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3,4- and 3,5-disubstituted 2-pyridones using an intermolecular cycloaddition/cycloreversion strategy: toward the synthesis of aristopyridinone A

Autor: Jonathan R. Scheerer, Maren K. Leibowitz, Ethan S. Winter

Publikováno v: Tetrahedron Letters. 56:6069-6072

The intermolecular cycloaddition of pyrazinone precursors with alkyne substrates was evaluated. The resulting regioisomeric [2.2.2]-diketopiperazine alkene cycloadducts were diverted into 2-pyridone products through cycloreversion of the [2.2.2]-bicy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84163b2fce5379a56d8970cd4f311ef0
https://doi.org/10.1016/j.tetlet.2015.09.067

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