Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition

Autor: Jonathan D. Strope, William D. Figg, John A. Beutler, Zhenhua Wu, David J. Beech, Melody Moy, Fernando Bravo, Antonio M. Echavarren, Sarka Tumova, William J. Chain, Jean-Simon Suppo, Cody J. Peer, Ethan S Weinstein

Publikováno v: ACS Med Chem Lett
RECERCAT (Dipòsit de la Recerca de Catalunya)
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
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[Image: see text] Modifications at the bridgehead position of englerin A were made to explore the effects of variation at this site on the molecule for biological activity, as judged by the NCI 60 screen, in which englerin A is highly potent and sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb887eb6565dbf55fff69853733864f
https://europepmc.org/articles/PMC7488277/