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pro vyhledávání: '"Ethan P. Metz"'
Autor:
Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter, Angie Rizzino
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could he
Externí odkaz:
https://doaj.org/article/b53a1360cbb5429d91603e9c267a376e
Autor:
Ethan P. Metz, Phillip J. Wilder, Tessa M. Popay, Jing Wang, Qi Liu, Achyuth Kalluchi, M. Jordan Rowley, William P. Tansey, Angie Rizzino
Publikováno v:
Cancers; Volume 14; Issue 8; Pages: 1946
Slowly cycling/infrequently proliferating tumor cells present a clinical challenge due to their ability to evade treatment. Previous studies established that high levels of SOX2 in both fetal and tumor cells restrict cell proliferation and induce a s
Autor:
Phillip J. Wilder, Don W. Coulter, Ethan P. Metz, Jesse L. Cox, Angie Rizzino, Kaustubh Datta, Erin L. Wuebben
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Background Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could help identi
Abstract 2478: Elevating SOX2 inhibits the proliferation of tumor cells independently of DNA binding
Publikováno v:
Cancer Research. 81:2478-2478
Purpose: The purpose of these studies was to understand how elevated SOX2 affects tumor cell proliferation. The stem cell transcription factor SOX2 has been implicated in ~20 different tumor types. Importantly, several studies have demonstrated that
Publikováno v:
J Cell Physiol
Prostate cancer (PCa) is one of the leading causes of cancer deaths in men. In this cancer, the stem cell transcription factor SOX2 increases during tumor progression, especially as the cancer progresses to the highly aggressive neuroendocrine-like p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a8f1735d60b321bc845297ae9cc052
https://europepmc.org/articles/PMC6961844/
https://europepmc.org/articles/PMC6961844/
Autor:
Angie Rizzino, Ethan P. Metz
Publikováno v:
J Cell Physiol
The stem cell transcription factor Sox2 is widely recognized for its many roles during normal development and cancer. Over the last several years, it has become increasingly evident that Sox2 dosage plays critical roles in both normal and malignant c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6ded5f3e8673c3a0a59d1e8d93bcfc
https://europepmc.org/articles/PMC6662612/
https://europepmc.org/articles/PMC6662612/