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pro vyhledávání: '"Ethan N.W. Howe"'
Autor:
Alexander M. Gilchrist, Lijun Chen, Xin Wu, William Lewis, Ethan N.W. Howe, Lauren K. Macreadie, Philip A. Gale
Publikováno v:
Molecules, Vol 25, Iss 21, p 5179 (2020)
Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via interacting with fatty acids
Externí odkaz:
https://doaj.org/article/460f9e2167714450aea9d00f903d36a7
Autor:
Ethan N.W. Howe, Vai-Vai Tiffany Chang, Xin Wu, William Lewis, Lauren K. Macreadie, Philip Alan Gale
Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour known to be regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was found to be inactive at pH 7.2 due to lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386bc2830f5a033d7baf111721914e07
https://doi.org/10.26434/chemrxiv-2021-m85zk
https://doi.org/10.26434/chemrxiv-2021-m85zk
Autor:
Ethan N.W. Howe, Philip Gale
We report an example of the use of fatty acids to drive chloride transport by creating a pH gradient across a vesicular lipid bilayer membrane. Addition of an unselective squaramide-based chloride transporter (which transports both H+and Cl-) facilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cf70c2f9332673f7d488c4a88e3008
https://doi.org/10.26434/chemrxiv.6823352
https://doi.org/10.26434/chemrxiv.6823352