Výsledky vyhledávání - "Ethan M. Weiner"

NMR structure-based optimization ofStaphylococcus aureussortase A pyridazinone inhibitors

Autor: Brendan R. Amer, Robert T. Clubb, Jeff Wereszczynski, Lloyd S. Miller, J. Andrew McCammon, Carly A. Dillen, Ethan M. Weiner, Sung Wook Yi, Silvia Senese, Jorge Z. Torres, Christopher K. Sue, Albert H. Chan, Michael E. Jung

Publikováno v: Chemical Biology & Drug Design. 90:327-344

Staphylococcus aureus is a leading cause of hospital-acquired infections in the United States and is a major health concern as methicillin-resistant S. aureus (MRSA) and other antibiotic resistant strains are common. Compounds that inhibit the S. aur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0923e8b5313f829b3f01d533d2ab6a2b
https://doi.org/10.1111/cbdd.12962

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Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication

Autor: Shewit S. Tekeste, Stuart F.J. Le Grice, Ethan M. Weiner, Jennifer T. Miller, Robert T. Clubb, Thomas A. Wilkinson, Xiaowen Xu, Samson A. Chow

Publikováno v: Journal of virology, vol 89, iss 23

Human immunodeficiency virus type 1 (HIV-1) replication requires reverse transcription of its RNA genome into a double-stranded cDNA copy, which is then integrated into the host cell chromosome. The essential steps of reverse transcription and integr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a4998bec0fb8d18a094a1446c3cb3e
https://doi.org/10.1128/jvi.01471-15

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Sortase enzymes in Gram-positive bacteria

Autor: Robert T. Clubb, Thomas Spirig, Ethan M. Weiner

Publikováno v: Molecular Microbiology. 82:1044-1059

In Gram-positive bacteria proteins are displayed on the cell surface using sortase enzymes. These cysteine transpeptidases join proteins bearing an appropriate sorting signal to strategically positioned amino groups on the cell surface. Working alone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a126490858700d67f10f10d29e9c182
https://doi.org/10.1111/j.1365-2958.2011.07887.x

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The Sortase A Enzyme That Attaches Proteins to the Cell Wall of Bacillus anthracis Contains an Unusual Active Site Architecture*

Autor: Scott A. Robson, Ethan M. Weiner, Robert T. Clubb, Melanie Marohn

The pathogen Bacillus anthracis uses the Sortase A (SrtA) enzyme to anchor proteins to its cell wall envelope during vegetative growth. To gain insight into the mechanism of protein attachment to the cell wall in B. anthracis we investigated the stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b824201bb7403042c2a03f8b21eef2cb
https://europepmc.org/articles/PMC2906334/

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