Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Ethan M. Shevach"'
Autor:
Lyra Morina, Madalyn E. Jones, Cihan Oguz, Mariana J. Kaplan, Arunakumar Gangaplara, Courtney D. Fitzhugh, Christopher G. Kanakry, Ethan M. Shevach, Maja Buszko
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Foxp3 is regarded as the major transcription factor for T regulatory (Treg) cells and expression of Foxp3 is used to identify and quantitate Treg cells in mouse models. However, several studies have demonstrated that human CD4+ T conventional (Tconv)
Externí odkaz:
https://doaj.org/article/d82042a167c74c42a972bee0383269e4
Autor:
Ying Shao, William Y. Yang, Fatma Saaoud, Charles Drummer IV, Yu Sun, Keman Xu, Yifan Lu, Huimin Shan, Ethan M. Shevach, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Tregs play vital roles in suppressing atherogenesis. Pathological conditions reshape Tregs and increase Treg-weakening plasticity. It remains unclear how Tregs preserve their function and how Tregs switch into alternative phenotypes in the environmen
Externí odkaz:
https://doaj.org/article/85498262eb0349ee97a77cd019a6da27
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The production of antibody-secreting plasma cells and memory B cells requires the interaction of T follicular helper (Tfh) cells with B cells in the follicle and is modulated by T follicular regulatory (Tfr) cells. We compare the effects of Tfr cells
Externí odkaz:
https://doaj.org/article/030653a02c104b259dfe8dd120e627e8
Autor:
Yujian H. Yang, Roman Istomine, Fernando Alvarez, Tho-Alfakar Al-Aubodah, Xiang Qun Shi, Tomoko Takano, Angela M. Thornton, Ethan M. Shevach, Ji Zhang, Ciriaco A. Piccirillo
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1515-1529.e4 (2020)
Summary: Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study
Externí odkaz:
https://doaj.org/article/8b33c085871f449f89fb91c11d935cc7
Autor:
Pulak Ranjan Nath, Arunakumar Gangaplara, Dipasmita Pal-Nath, Ajeet Mandal, Dragan Maric, John M. Sipes, Maggie Cam, Ethan M. Shevach, David D. Roberts
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CD47 is a ubiquitous cell surface receptor that directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1 and limits clearance of cells by phagocytes that express its counter-receptor signal-regulatory protein-α.
Externí odkaz:
https://doaj.org/article/0f38725fed414e4db318db6066e217fa
Autor:
Ethan M. Shevach
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T regulatory (Treg) cells were discovered more than 20 years ago and have remained a topic of intense investigation by immunologists. The initial doubts about their existence were dissipated by the discovery in 2003 of the lineage specific transcript
Externí odkaz:
https://doaj.org/article/8aa1822a70ce465b97d667cff8483585
Autor:
Geraldo M. B. Pereira, Gláucia de C. Furtado, Wayne M. Yokoyama, Thereza L. Kipnis, Ethan M. Shevach
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 83, Pp 284-290 (1988)
Externí odkaz:
https://doaj.org/article/9d44b7b778a240209da0fde8ead862f8
Autor:
Ethan M. Shevach, Maja Buszko
Publikováno v:
Current Opinion in Immunology. 67:18-26
CD4+ Foxp3+ T Regulatory (Treg) cells play a critical role in the homeostasis and maintenance of the immune system. The understanding of different aspects of Treg cells biology remains an intensively investigated subject as altering their generation,
Autor:
Arunakumar Gangaplara, Maja Buszko, Lisa F. Boyd, Suveena Sharma, Kannan Natarajan, Abir K. Panda, David H. Margulies, Ethan M. Shevach
Publikováno v:
J Immunol
NK cells recognize MHC class I (MHC-I) Ags via stochastically expressed MHC-I–specific inhibitory receptors that prevent NK cell activation via cytoplasmic ITIM. We have identified a pan anti–MHC-I mAb that blocks NK cell inhibitory receptor bind
Autor:
Fatma Saaoud, Keman Xu, Xiaohua Jiang, Ying Shao, Yu Sun, Xiaofeng Yang, Hong Wang, Huimin Shan, William Y. Yang, Ethan M. Shevach, Yifan Lu, Charles Drummer
Publikováno v:
JCI Insight
Tregs play vital roles in suppressing atherogenesis. Pathological conditions reshape Tregs and increase Treg-weakening plasticity. It remains unclear how Tregs preserve their function and how Tregs switch into alternative phenotypes in the environmen