Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ethan M. Grund"'
Autor:
Benjamin D.S. Clarkson, Ethan M. Grund, Miranda M. Standiford, Kanish Mirchia, Maria S. Westphal, Liz S. Muschler, Charles L. Howe
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with disease progression, but the pathogenic role and antigenic targets of these clonally expanded effectors are unknown. Based on evidence that demyelination is necessar
Externí odkaz:
https://doaj.org/article/d3e995d405734c7cb2114fe8c13949a4
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
Externí odkaz:
https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9
Autor:
Parijat Kabiraj, Ethan M. Grund, Benjamin D. S. Clarkson, Renee K. Johnson, Reghann G. LaFrance-Corey, Claudia F. Lucchinetti, Charles L. Howe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Astrocytes utilize both glycolytic and mitochondrial pathways to power cellular processes that are vital to maintaining normal CNS functions. These cells also mount inflammatory and acute phase reactive programs in response to diverse stimul
Externí odkaz:
https://doaj.org/article/6082d9204e764fd28bf335baa7845997
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Microglia are the primary phagocytes of the central nervous system and are responsible for removing damaged myelin following demyelination. Previous investigations exploring the consequences of myelin phagocytosis on microglial ac
Externí odkaz:
https://doaj.org/article/51cf6a9e5ba6479ca532c06010660dc7
Autor:
Shannon R. Hinson, Josephe A. Honorat, Ethan M. Grund, Benjamin D. Clarkson, Ramona Miske, Madeleine Scharf, Cecilia Zivelonghi, Muhammad Taher Al‐Lozi, Robert C. Bucelli, Adrian Budhram, Tracey Cho, Ellie Choi, Jacquelyn Grell, Alfonso Sebastian Lopez‐Chiriboga, Marc Levin, Melody Merati, Mayra Montalvo, Sean J. Pittock, Michael R. Wilson, Charles L. Howe, Andrew McKeon
Publikováno v:
Annals of neurology. 92(6)
We sought to determine clinical significance of neuronal septin autoimmunity and evaluate for potential IgG effects.Septin-IgGs were detected by indirect immunofluorescence assays (IFAs; mouse tissue and cell based) or Western blot. IgG binding to (a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e579fb34e82ca0aeb2c71a9c377f3fd
https://pubmed.ncbi.nlm.nih.gov/36053822
https://pubmed.ncbi.nlm.nih.gov/36053822
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature communications. 13(1)
Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In the aged brain, senescent cell identities and the mechanisms by which they exert adverse influence are unclear. Here we used high-dimensional molecular profili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd63d089cbb1ae9984ade62880d2973a
https://pubmed.ncbi.nlm.nih.gov/36167854
https://pubmed.ncbi.nlm.nih.gov/36167854
Autor:
Gerard Fejes-Toth, Aniko Naray Fejes-Toth, Florian Lang, Steven Einheber, James L. Salzer, Grant Morahan, Maria Laura Feltri, Luba Kalaydjieva, Ethan M. Grund, Bradley A. Heller, Monica Ghidinelli, Ryan Smith, Jakob Voelkl, Rosalind H.M. King, David Chandler, Filippo G. Giancotti
Publikováno v:
The Journal of Cell Biology
Functionally and spatially distinct PI 3-K pathways act either early to promote myelination downstream of axonal Neuregulin1 or late to inhibit myelination downstream of α6β4 integrin and Sgk1.
The PI 3-kinase (PI 3-K) signaling pathway is ess
The PI 3-kinase (PI 3-K) signaling pathway is ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8937fd849e07b5682c84aa198de445db
http://europepmc.org/articles/PMC3971744
http://europepmc.org/articles/PMC3971744
Publikováno v:
The Journal of Immunology. 202:180.1-180.1
Clonally expanded CD8+ T cells outnumber their CD4+ counterparts in MS lesions yet their role in disease pathogenesis and the relevant target antigen(s) remain unknown. We posited that CNS CD8+ T cells are specific for neuronal antigen and may partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50050c3105bddfc5a5a3a4dbc33e46a9
https://doi.org/10.4049/jimmunol.202.supp.180.1
https://doi.org/10.4049/jimmunol.202.supp.180.1
Autor:
Ashik H. Siddique, Daniel Kim, Frances M. Paley, Sue-Jung Jang, John G. Seamon, Christopher Liong, Inslee E. Coddington, Maritza C. Ebling, Catherine T. Haring, Ethan M. Grund, Luke K. Pang, Justin M. Bohn
Publikováno v:
Journal of Experimental Psychology: Learning, Memory, and Cognition. 38:1045-1056
Research from the adaptive memory framework shows that thinking about words in terms of their survival value in an incidental learning task enhances their free recall relative to other semantic encoding strategies and intentional learning (Nairne, Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179f70f2d1b53cdaa537b2348e8996a7
https://doi.org/10.1037/a0027090
https://doi.org/10.1037/a0027090
Autor:
Gord Fishell, Hernandez Moura Silva, James L. Salzer, Juan J. Lafaille, Ethan M. Grund, Jayshree Samanta
Publikováno v:
Nature. 526(7573)
Enhancing repair of myelin is an important but still elusive therapeutic goal in many neurological disorders1. In multiple sclerosis, an inflammatory demyelinating disease, endogenous remyelination does occur but is frequently insufficient to restore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8cb8f9210ffbb1de5572a3f69cd335
https://pubmed.ncbi.nlm.nih.gov/26481096
https://pubmed.ncbi.nlm.nih.gov/26481096