Výsledky vyhledávání - "Ethan G Geier"

Akademický článek

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

Autor: Daniel W. Sirkis, Caroline Warly Solsberg, Taylor P. Johnson, Luke W. Bonham, Virginia E. Sturm, Suzee E. Lee, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, Bruce L. Miller, Ethan G. Geier, Jennifer S. Yokoyama

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-22 (2023)

Abstract Background Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau path

Externí odkaz: https://doaj.org/article/593d8cbdd12d4eee9bf2368860ac1c9f

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Akademický článek

Early‐onset Alzheimer's disease explained by polygenic risk of late‐onset disease?

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)

Abstract Early‐onset Alzheimer's disease (AD) is highly heritable, yet only 10% of cases are associated with known pathogenic mutations. For early‐onset AD patients without an identified autosomal dominant cause, we hypothesized that their early�

Externí odkaz: https://doaj.org/article/4906107fb48d48b98f50a0cb0d77e800

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Akademický článek

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

Autor: Alyssa E. Johnson, Brian O. Orr, Richard D. Fetter, Armen J. Moughamian, Logan A. Primeaux, Ethan G. Geier, Jennifer S. Yokoyama, Bruce L. Miller, Graeme W. Davis

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, anima

Externí odkaz: https://doaj.org/article/aa6baecf1a634bae8c342d74ef2c74a7

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Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 43, iss 2

Hexanucleotide repeat expansion (HRE) within C9orf72 is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26db290663368430e8978af72589564d
https://escholarship.org/uc/item/7jr289cm

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Akademický článek

Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer’s Disease

Autor: Jessie S. Carr, Luke W. Bonham, Alicia K. Morgans, Charles J. Ryan, Jennifer S. Yokoyama, Ethan G. Geier, Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)

Alzheimer’s disease (AD) prevalence varies by sex, suggesting that sex chromosomes, sex hormones and/or their signaling could potentially modulate AD risk and progression. Low testosterone levels are reported in men with AD. Further, variation in t

Externí odkaz: https://doaj.org/article/10c7240fec8f43dda344e11851c523b0

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Akademický článek

Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice

Autor: Luke W. Bonham, Ethan G. Geier, Natasha Z. R. Steele, Dominic Holland, Bruce L. Miller, Anders M. Dale, Rahul S. Desikan, Jennifer S. Yokoyama, Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)

There is increasing evidence that metabolic dysfunction plays an important role in Alzheimer’s disease (AD). Brain insulin resistance and subsequent impairment of insulin and insulin-like growth factor (IGF) signaling are associated with the neurod

Externí odkaz: https://doaj.org/article/88420118ebcc42818c565c74f9d28649

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Single-cell RNA-seq reveals alterations in peripheralCX3CR1and nonclassical monocytes in familial tauopathy

BackgroundEmerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau pathology and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaf3b57fa13216a45a296bff1cd7973e
https://doi.org/10.1101/2022.10.28.514304

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