Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ethan A Mack"'
Autor:
Sarah J Stein, Ethan A Mack, Kelly S Rome, Kostandin V Pajcini, Takuya Ohtani, Lanwei Xu, Yunlei Li, Jules P P Meijerink, Robert B Faryabi, Warren S Pear
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155408 (2016)
Trib2 is highly expressed in human T cell acute lymphoblastic leukemia (T-ALL) and is a direct transcriptional target of the oncogenic drivers Notch and TAL1. In human TAL1-driven T-ALL cell lines, Trib2 is proposed to function as an important surviv
Externí odkaz:
https://doaj.org/article/4a24ef311aa44b3886fece58b3199e5d
Publikováno v:
The Journal of Applied Laboratory Medicine. 7:1492-1495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd9dab184ca5cdc75e38d9aa73ff724
https://doi.org/10.1093/jalm/jfac083
https://doi.org/10.1093/jalm/jfac083
Autor:
Sarah J. Stein, Kelly S. Rome, Gerald Wertheim, Ethan A. Mack, Warren S. Pear, Lanwei Xu, Rossana C. N. Melo
Publikováno v:
Blood
Eosinophils and neutrophils are critical for host defense, yet gaps in understanding how granulocytes differentiate from hematopoietic stem cells (HSCs) into mature effectors remain. The pseudokinase tribbles homolog 1 (Trib1) is an important regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0a8f9c80190822a3aa4e86b4341e99
https://doi.org/10.1182/blood.2018872218
https://doi.org/10.1182/blood.2018872218
Autor:
Martha S. Jordan, Phyllis A. Gimotty, Anne G. DeHart, Robert B. Faryabi, E. John Wherry, Jelena Petrovic, Kelly S. Rome, Sarah J. Stein, Ethan A. Mack, Winona W. Wu, Makoto Kurachi, Stephen C. Blacklow, Sacha N. Uljon, Lanwei Xu, Gregory W. Schwartz, Warren S. Pear, Susan McClory
Publikováno v:
The Journal of Experimental Medicine
Rome et al. show that Trib1 controls effector versus exhausted T cell differentiation and function by restraining effector programming during persistent infection, revealing a new regulatory axis that could be targeted to recover waning T cell respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aee51e1da73d48aa8852d9e5e77c70
https://doi.org/10.1084/jem.20190888
https://doi.org/10.1084/jem.20190888
Autor:
Warren S. Pear, Ethan A. Mack
Publikováno v:
Curr Opin Hematol
PURPOSE OF REVIEW: Lineage commitment is governed by instructive and stochastic signals which drive both active induction of the lineage program as well as repression of alternative fates. Eosinophil lineage commitment is driven by the ordered intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76578fea61a3e82d4f13397b027fefcc
https://pubmed.ncbi.nlm.nih.gov/31688456
https://pubmed.ncbi.nlm.nih.gov/31688456
Publikováno v:
Biochemical Society Transactions
The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular events including those involved in normal and malignant haematopoiesis. The three mammalian Tribbles homologues, Trib1, Tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01db42a347cb51d5f0a917f1718530cf
https://doi.org/10.1042/bst20150117
https://doi.org/10.1042/bst20150117
Autor:
Maria Luisa Visciano, Michael Tuen, Ethan A. Mack, Rachel E. Simon, Jianping Liu, Catarina E. Hioe, Rajnish Kumar, David N. Levy
Publikováno v:
Vaccine. 28:352-360
The capacity of immune complexes to augment antibody (Ab) responses is well established. The enhancing effects of immune complexes have been attributed mainly to Fc-mediated adjuvant activity, while the ability of Abs to induce antigenic alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00eb4c48f9194ef2d6bbfc95e8dd29c8
https://doi.org/10.1016/j.vaccine.2009.10.040
https://doi.org/10.1016/j.vaccine.2009.10.040
Publikováno v:
mBio, Vol 2, Iss 4 (2011)
mBio
mBio
Natural killer (NK) cells are equipped to innately produce the cytokine gamma interferon (IFN-γ) in part because they basally express high levels of the signal transducer and activator of transcription 4 (STAT4). Type 1 interferons (IFNs) have the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964eecc76a6511b92e106dd044eac57f
https://doi.org/10.1128/mbio.00169-11
https://doi.org/10.1128/mbio.00169-11
Publikováno v:
mBio, Vol 2, Iss 4 (2011)
ABSTRACT Natural killer (NK) cells are equipped to innately produce the cytokine gamma interferon (IFN-γ) in part because they basally express high levels of the signal transducer and activator of transcription 4 (STAT4). Type 1 interferons (IFNs) h
Externí odkaz:
https://doaj.org/article/26b87778cad4404e857b56b44b98b728