Using fluorescence polarization immunoassay for determination of erythrocyte methotrexate polyglutamates, a quick and easy test?

Autor: Birgit C. P. Koch, Robert de Jonge, Ethan den Boer, Ruud Huisman

Publikováno v: Therapeutic Drug Monitoring, 36(6), 819-823. Lippincott Williams and Wilkins
Therapeutic Drug Monitoring, 36(6), 819-823. Lippincott Williams & Wilkins
Den Boer, E, Koch, B C, Huisman, R & De Jonge, R 2014, ' Using fluorescence polarization immunoassay for determination of erythrocyte methotrexate polyglutamates, a quick and easy test? ', Therapeutic Drug Monitoring, vol. 36, no. 6, pp. 819-823 . https://doi.org/10.1097/FTD.0000000000000085

BACKGROUND:: The folate antagonist methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis. The therapeutic effects of MTX are attributed to the intracellular levels of MTX, present in the cell as polyglutamates (MTX-PGs). We a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622462a801736004b40de0badc5842b3
https://doi.org/10.1097/ftd.0000000000000085

Letter to the editor in response to the article 'Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients' by Kivity S, Zafrir Y, Loebstein R, Pauzner R, Mouallem M, Mayan H, Autoimmun Rev. 2014 Nov.;13(11):1109-13 Height of MTX-PG levels in low-dose MTX-toxicity differs according to the time of onset

Autor: Robert de Jonge, Johanna M. W. Hazes, Elsbeth M. Westerman, Sophie Wassenaar, Ethan den Boer

Publikováno v: Autoimmunity Reviews, 15(11), 1109-1110. Elsevier
Wassenaar, S, den Boer, E, Westerman, E M, Hazes, J M & de Jonge, R 2016, ' Letter to the editor in response to the article "Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients" by Kivity S, Zafrir Y, Loebstein R, Pauzner R, Mouallem M, Mayan H, Autoimmun Rev. 2014 Nov.;13(11):1109-13 Height of MTX-PG levels in low-dose MTX-toxicity differs according to the time of onset ', Autoimmunity Reviews, vol. 15, no. 11, pp. 1109-1110 . https://doi.org/10.1016/j.autrev.2016.04.006

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997d1aef2ac2b98ec6e38299d1f961b5
https://research.vumc.nl/en/publications/d5c9ec15-c215-47ad-8754-3a69ae6dbff6

A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients

Autor: Theo M. Luider, Robert de Jonge, Rob J. van Klaveren, Ethan den Boer, Jan Lindemans, Roland J. W. Meesters, Robin Cornelissen

Publikováno v: Analytical and Bioanalytical Chemistry, 398(7-8), 2943-2948. Springer-Verlag
Analytical and Bioanalytical Chemistry

An analytical assay has been developed and validated for ultrafast and high-throughput mass spectrometric determination of pemetrexed concentrations in plasma using matrix assisted laser desorption/ionization-triple quadrupole-tandem mass spectrometr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbef9f55e2a7b7122e3d9e7f1d1b465
https://pure.eur.nl/en/publications/8238cb22-f2d8-42c0-b43e-48f271b18c42

Methotrexate polyglutamates in erythrocytes are associated with lower disease activity in juvenile idiopathic arthritis patients

Autor: Ethan den Boer, Maja Bulatović Ćalasan, Robert de Jonge, Sebastiaan J. Vastert, Nico M Wulffraat, Maurits C F J de Rotte, Sylvia Kamphuis

Publikováno v: Annals of the Rheumatic Diseases, 74(2), 402-407. BMJ Publishing Group
Ćalasan, M B, Den Boer, E, De Rotte, M C F J, Vastert, S J, Kamphuis, S, De Jonge, R & Wulffraat, N M 2015, ' Methotrexate polyglutamates in erythrocytes are associated with lower disease activity in juvenile idiopathic arthritis patients ', Annals of the Rheumatic Diseases, vol. 74, no. 2, pp. 402-407 . https://doi.org/10.1136/annrheumdis-2013-203723

Objective: To determine association of erythrocyte methotrexate polyglutamates (MTX-PG) with disease activity and adverse effects in a prospective juvenile idiopathic arthritis (JIA) cohort. Methods: One hundred and thirteen JIA patients were followe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce9a7198c1b8ff600b617879edb70ce
https://pubmed.ncbi.nlm.nih.gov/24288013

Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry

Autor: Roland J W, Meesters, Ethan, den Boer, Robert, de Jonge, Jan, Lindemans, Theo M, Luider

Publikováno v: Rapid communications in mass spectrometry : RCM. 25(20)

A new ultrafast quantitative and high-throughput mass spectrometric method using matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry has been developed and validated for determination of intracellular erythrocyte co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0df6a3e29606050354bf3e9a63f5e2b4
https://pubmed.ncbi.nlm.nih.gov/21953961