The hypotensive response to des-Arg9-bradykinin increases during E. coli septicemia in the pig

Autor: matthias siebeck, Et, Whalley, Hoffmann H, Weipert J, Fritz H

Publikováno v: Europe PubMed Central

The sensitivity to des-Arg9-bradykinin of the cardiovascular system was largely increased in piglets with E. coli bacteremia. However, the sensitivity to bradykinin was unchanged under the same condition. These findings indicate the appearance of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6a5b43f1141c8f4201c93444470fd0da
https://pubmed.ncbi.nlm.nih.gov/2692415

Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction.

Autor: Tofovic SP; Vascular Medicine Institute (S.P.T.) and the Departments of Medicine (S.P.T., E.K.J.), Pathology (E.M.S.), and Pharmacology and Chemical Biology (E.K.J.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Biogen Idec, Inc., Cambridge, Massachusetts (G.J.S., E.T.W., B.T., A.D.)., Salah EM; Vascular Medicine Institute (S.P.T.) and the Departments of Medicine (S.P.T., E.K.J.), Pathology (E.M.S.), and Pharmacology and Chemical Biology (E.K.J.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Biogen Idec, Inc., Cambridge, Massachusetts (G.J.S., E.T.W., B.T., A.D.)., Smits GJ; Vascular Medicine Institute (S.P.T.) and the Departments of Medicine (S.P.T., E.K.J.), Pathology (E.M.S.), and Pharmacology and Chemical Biology (E.K.J.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Biogen Idec, Inc., Cambridge, Massachusetts (G.J.S., E.T.W., B.T., A.D.)., Whalley ET; Vascular Medicine Institute (S.P.T.) and the Departments of Medicine (S.P.T., E.K.J.), Pathology (E.M.S.), and Pharmacology and Chemical Biology (E.K.J.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Biogen Idec, Inc., Cambridge, Massachusetts (G.J.S., E.T.W., B.T., A.D.)., Ticho B; Vascular Medicine Institute (S.P.T.) and the Departments of Medicine (S.P.T., E.K.J.), Pathology (E.M.S.), and Pharmacology and Chemical Biology (E.K.J.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Biogen Idec, Inc., Cambridge, Massachusetts (G.J.S., E.T.W., B.T., A.D.)., Deykin A; Vascular Medicine Institute (S.P.T.) and the Departments of Medicine (S.P.T., E.K.J.), Pathology (E.M.S.), and Pharmacology and Chemical Biology (E.K.J.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Biogen Idec, Inc., Cambridge, Massachusetts (G.J.S., E.T.W., B.T., A.D.)., Jackson EK; Vascular Medicine Institute (S.P.T.) and the Departments of Medicine (S.P.T., E.K.J.), Pathology (E.M.S.), and Pharmacology and Chemical Biology (E.K.J.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Biogen Idec, Inc., Cambridge, Massachusetts (G.J.S., E.T.W., B.T., A.D.) edj@pitt.edu.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2016 Feb; Vol. 356 (2), pp. 333-40. Date of Electronic Publication: 2015 Nov 19.

Serum IL-17F does not predict poor response to IM IFNβ-1a in relapsing-remitting MS.

Autor: Bushnell SE; Biogen Idec, Cambridge, MA, USA. steven.bushnell@biogenidec.com, Zhao Z, Stebbins CC, Cadavid D, Buko AM, Whalley ET, Davis JA, Versage EM, Richert JR, Axtell RC, Steinman L, Medori R

Publikováno v: Neurology [Neurology] 2012 Aug 07; Vol. 79 (6), pp. 531-7. Date of Electronic Publication: 2012 May 09.

Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.

Autor: Yao G; Departments of Medicinal Chemistry and Pharmacology, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA. gang.yao@biogenidec.com, Haque S, Sha L, Kumaravel G, Wang J, Engber TM, Whalley ET, Conlon PR, Chang H, Kiesman WF, Petter RC

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Feb 01; Vol. 15 (3), pp. 511-5.

Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE.

Autor: Theien BE; Department of Microbiology-Immunology, Northwestern University Medical School, 303 East Chicago Ave, Chicago, IL 60611, USA., Vanderlugt CL, Nickerson-Nutter C, Cornebise M, Scott DM, Perper SJ, Whalley ET, Miller SD

Publikováno v: Blood [Blood] 2003 Dec 15; Vol. 102 (13), pp. 4464-71. Date of Electronic Publication: 2003 Aug 21.