Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Eszter Doma"'
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19361-19384 (2013)
The mammalian skin is the largest organ of the body and its outermost layer, the epidermis, undergoes dynamic lifetime renewal through the activity of somatic stem cell populations. The EGFR-Ras-Raf pathway has a well-described role in skin developme
Externí odkaz:
https://doaj.org/article/a4e74323c8874cc6a0db3e760126f419
Autor:
Krittalak Chakrabandhu, Sébastien Huault, Jérôme Durivault, Kévin Lang, Ly Ta Ngoc, Angelique Bole, Eszter Doma, Benoit Dérijard, Jean-Pierre Gérard, Michel Pierres, Anne-Odile Hueber
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002401 (2016)
Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive "Fas apoptosis" to "Fas multisignals" paradigm and the acceptance that Fas-related therapies face a major challenge, as
Externí odkaz:
https://doaj.org/article/1fb1d4ffabc3436098b9f496b5080dc0
Autor:
Tania Brandstoetter, Johannes Schmoellerl, Reinhard Grausenburger, Sebastian Kollmann, Eszter Doma, Jani Huuhtanen, Thorsten Klampfl, Thomas Eder, Florian Grebien, Gregor Hoermann, Johannes Zuber, Satu Mustjoki, Barbara Maurer, Veronika Sexl
Publikováno v:
Blood. 141:1831-1845
Funding Information: The authors thank Sabine Fajmann, Petra Kudweis, Philipp Jodl, and Isabella Mayer for excellent experimental support. The authors thank the Biomedical Sequencing Facility at the CeMM Research Center for Molecular Medicine at the
PDF file - 680K, B‐Raf or C‐Raf ablation prevents tumor development in PLX‐4032‐treated KS‐SOS‐F+ mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220504f95d64e0e9d0b0ffb514f375e3
https://doi.org/10.1158/0008-5472.22400447.v1
https://doi.org/10.1158/0008-5472.22400447.v1
RAF inhibitors achieve unprecedented but mainly transient clinical responses in patients with melanoma whose tumors harbor an activating BRAF mutation. One notable side-effect of RAF inhibitors is the stimulation of cutaneous skin tumors, arising in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b69d037496b5fa14b770425450ee192b
https://doi.org/10.1158/0008-5472.c.6505592
https://doi.org/10.1158/0008-5472.c.6505592
PDF file - 185K, Effect of Rok inhibitors on K5‐SOS‐F+; C‐RafKO epithelia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c844baacf7daec99cd21d53b7b20e7
https://doi.org/10.1158/0008-5472.22400435
https://doi.org/10.1158/0008-5472.22400435
PDF file - 197K, Effect of GDC‐0879 on wild‐type mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3048c30aad2f998cd42ec42832150e31
https://doi.org/10.1158/0008-5472.22400456.v1
https://doi.org/10.1158/0008-5472.22400456.v1
PDF file - 213K, C‐Raf, but not B‐Raf ablation, prevents tumor development in GDC‐0879 treated K5‐ SOS‐F+ mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5288ce4d76cc2603abd3feea624e5fd6
https://doi.org/10.1158/0008-5472.22400444.v1
https://doi.org/10.1158/0008-5472.22400444.v1
PDF file - 1000K, The Mek inhibitor trametinib prevents Ras‐ and Ras+Raf inhibitor‐induced tumorigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275723d666f59e328df05c11f174c20f
https://doi.org/10.1158/0008-5472.22400450.v1
https://doi.org/10.1158/0008-5472.22400450.v1
PDF file - 74K, B‐ and C‐Raf are required for PLX‐4032, but not GDC‐0879‐induced ERK phosphorylation in primary wild‐type keratinocytes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b093ede7dde8d7c359b619ebc056e0e
https://doi.org/10.1158/0008-5472.22400438.v1
https://doi.org/10.1158/0008-5472.22400438.v1