Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Eswaran Devarajan"'
Autor:
Eswaran Devarajan, R. Eric Davis, Hannah C. Beird, Wei-Lien Wang, V. Behrana Jensen, Arumugam Jayakumar, Cheuk Hong Leung, Heather Y. Lin, Chia-Chin Wu, Stephanie A. Ihezie, Jen-Wei Tsai, P. Andrew Futreal, Valerae O. Lewis
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Lung metastases are the primary cause of death for osteosarcoma (OS) patients. We recently validated interleukin-11 receptor α (IL-11Rα) as a molecular target for the inhibition of OS lung metastases. Since there is no clinically approved
Externí odkaz:
https://doaj.org/article/82384a0da19f427989951c00e219d5ff
Autor:
Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song
Publikováno v:
Analytical Cellular Pathology, Vol 33, Iss 2, Pp 61-79 (2010)
Carcinoma-associated fibroblasts (CAF) are considered to contribute to tumor growth, invasion and metastasis. However, the cell type of origin remains unknown. Since human adipose tissue-derived stem cells (hASCs) are locally adjacent to breast cance
Externí odkaz:
https://doaj.org/article/c0590896b78a40c48c42a93565475da3
Autor:
Wadih Arap, Valerae O. Lewis, Serena Marchiò, Dafydd G. Thomas, Eswaran Devarajan, Renata Pasqualini, Marina Cardó-Vila, Richard L. Sidman, Eugenie S. Kleinerman
Publikováno v:
Proceedings of the National Academy of Sciences. 114:8065-8070
Osteosarcoma occurs predominantly in children and young adults. High-grade tumors require multidisciplinary treatment consisting of chemotherapy in the neoadjuvant and adjuvant settings, along with surgical intervention. Despite this approach, death
Autor:
Valerae O. Lewis, Vivek Subbiah, Pete Anderson, Robert E. Brown, Eswaran Devarajan, Shumei Kato, Nawid Sarwari, Michael J. Wagner, Shanon Westin, Mary F. McGuire
Publikováno v:
Oncotarget
// Vivek Subbiah 1 , Michael J. Wagner 1 , Mary F. McGuire 3 , Nawid M. Sarwari 4 , Eswaran Devarajan 5 , Valerae O. Lewis 5 , Shanon Westin 2 , Shumei Kato 1 , Robert E. Brown 3 , Pete Anderson 6 1 Department of Investigational Cancer Therapeutics,
Publikováno v:
International Journal of Cancer. 131:1023-1031
Epithelial-mesenchymal transition (EMT) generates tumor cells with stem cell properties. The aim of our study was to investigate the effects of adipose tissue-derived stem cells (ASCs) on EMT of cancer cells and to further investigate the mechanisms
Autor:
Srinivasalu Krishnappa, Eswaran Devarajan, Constantin Jotzu, Gabriel Welte, Yao-Hua Song, Eckhard Alt
Publikováno v:
Molecular Carcinogenesis. 51:861-868
The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migr
Autor:
Lilly Droll, Eswaran Devarajan, Yao-Hua Song, Severin Pinilla, Alexander Krohn, Ralph B. Arlinghaus, Max Seidensticker, Andrew M. Altman, Xiaohong Leng, Jens Ricke, Weili Liu, Eckhard Alt, Fabian Muehlberg
Publikováno v:
Muehlberg, Fabian L; Song, Yao-Hua; Krohn, Alexander; Pinilla, Severin; Droll, Lilly H.; Leng, Xiaohong; Seidensticker, Max; Ricke, Jens; Altman, Andrew M.; Devarajan, Eswaran; Liu, Weili; Arlinghaus, Ralph B.; Alt, Eckhard U. (2009). Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis, 30(4), pp. 589-597. Oxford University Press 10.1093/carcin/bgp036
Mesenchymal stem cells derived from bone marrow have recently been described to localize to breast carcinomas and to integrate into the tumor-associated stroma. In the present study, we investigated whether adipose tissue-derived stem cells (ASCs) co
Publikováno v:
Cancer Research. 65:10289-10297
Spleen tyrosine kinase (SYK) is a candidate tumor suppressor gene in breast. Loss of SYK expression in breast tumors as a result of DNA hypermethylation promotes tumor cell proliferation and invasion and predicts shorter survival of breast cancer pat
Autor:
Eswaran Devarajan, Kaliraj Perumal, Shiva Thirugnanam, Pankaj K. Mishra, Ramaswamy Chandrashekar, Kapil Mehta
Publikováno v:
Parasitology Research. 93:145-150
Prior studies have demonstrated that transglutaminase (TGase) from the human filarial parasite Brugia malayi is critical for the growth and development of the larval stages. In this report, we describe the cloning and partial characterization of a cD
Autor:
Neeraj Aggarwal, Fan Zhang, Jack S.K. Chen, Anne Marie Brun, Ann D. Tora, Eswaran Devarajan, Raghu R. Krishnamurthy, Dhawal Sharma, Kapil Mehta, Xiao He Yang, Anna Sapino, Aysegul A. Sahin
Publikováno v:
Oncogene. 21:8843-8851
Caspase-3 is a member of the cysteine protease family, which plays a crucial role in apoptotic pathways by cleaving a variety of key cellular proteins. Caspase-3 can be activated by diverse death-inducing signals, including the chemotherapeutic agent