Výsledky vyhledávání - "Eswar Reddy Maddi"

Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability

Autor: Ramanathan Natesh, Sathees C. Raghavan, Eswar Reddy Maddi

Publikováno v: Protein Engineering, Design and Selection. 34

Studies have shown that Lig4 syndrome mutations in DNA ligase IV (LigIV) are compromised in its function with residual level of double strand break ligation activity in vivo. It was speculated that Lig4 syndrome mutations adversely affect protein fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90552bee3816fd091d53fc40cfdba538
https://doi.org/10.1093/protein/gzab001

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Optimization strategies for expression and purification of soluble N-terminal domain of human centriolar protein SAS-6 in Escherichia coli

Autor: Ramanathan Natesh, Eswar Reddy Maddi

Publikováno v: Protein Expression and Purification. 183:105856

Spindle assembly abnormal protein 6 (SAS-6), a highly conserved centriolar protein, constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. Abnormalities in cartwheel assembly lead to chromosomal dysfunct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c80742cec9d3d35786d6678a34df1d
https://doi.org/10.1016/j.pep.2021.105856

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